David Dean, Ph.D., professor of Pediatrics and Neonatology at the 麻豆视频, has
received a $3 million grant to explore a novel method of gene therapy delivery that could greatly benefit patients
with acute respiratory distress syndrome (ARDS).
The syndrome, which occurs after trauma such as an injury or pneumonia, causes alveoli (tiny air sacs in the lungs)
to take on too much water and prevents the lungs from efficiently processing oxygen. It affects about 150,000 people
each year, and there is no cure 鈥 about 40 percent of people who are diagnosed die as a result.
Dean鈥檚 approach attempts to influence the affected alveoli from the inside out by using gene therapy to communicate
with the cells鈥 nuclei and decision-making centers. Using a carefully-devised DNA compound, the treatment compels
lung cells to release their extra water, allowing them to function properly again.
However, our cells are well-equipped to prevent rogue strands of DNA from entering 鈥 great for keeping viruses out,
but challenging for researchers who are trying to get helpful compounds in. Using a process called electroporation,
Dean delivers a measured shock of electricity that causes the cells in a target area to briefly open, allowing DNA
inside.
Electroporation is a burgeoning science in the field of gene therapy and there is minimal literature on its use
across the chest and lungs. The grant, from the National Institutes of Health, will allow Dean to continue to test
its safety and efficacy.
鈥淥ur research has generated very encouraging results thus far,鈥 said Dean. 鈥淚f it continues to show promise, our next
step will be a clinical trial.鈥