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Robert A. Mooney, Ph.D.

Robert A. Mooney, Ph.D.

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About Me

Director of the Biochemical Genetics Laboratory. Director of the Point-of-Care Testing Section. Co-Director of the Pathways of Human Disease Ph.D. Program in Pathology. Dr. Mooney also serves as the Director of Clinical Laboratories at Monroe Community Hospital and has served as Director of the Hem...
Director of the Biochemical Genetics Laboratory. Director of the Point-of-Care Testing Section. Co-Director of the Pathways of Human Disease Ph.D. Program in Pathology. Dr. Mooney also serves as the Director of Clinical Laboratories at Monroe Community Hospital and has served as Director of the Hemoglobinopathy Laboratory in the Department of Medicine.

Faculty Appointments

Professor Emeritus - Department of Pathology and Laboratory Medicine (SMD)

Credentials

Education

PhD | Johns Hopkins U Sch Medicine. Biochemistry. 1980

MA | Johns Hopkins U Sch Medicine. Biochemistry. 1973

BS | Rensselaer Polytech Inst. Chemistry. 1971

Research

Obesity is increasing at an alarming rate in the industrialized world. This is a serious health concern because there is a strong association between obesity and insulin resistance, type 2 diabetes, hypertension, cancer, and cardiovascular disease. Our lab is particularly interested in the link betw...
Obesity is increasing at an alarming rate in the industrialized world. This is a serious health concern because there is a strong association between obesity and insulin resistance, type 2 diabetes, hypertension, cancer, and cardiovascular disease. Our lab is particularly interested in the link between obesity and type 2 diabetes. Type 2 diabetes currently afflicts 6-7% of the U.S. population. It is characterized by defective insulin action (insulin resistance) leading to poor control of blood glucose (sugar) levels. The disease can lead to heart disease, blindness, kidney failure, amputations, and nerve damage. Sedentary lifestyle and poor eating habits leading to obesity are contributing to the increased incidence of diabetes at all ages.

It has now become apparent that obesity-dependent insulin resistance and type 2 diabetes have characteristics of a chronic inflammatory state. This link between inflammation and insulin resistance is the focus of our lab. In one area of our work, we are testing the hypothesis that cytokines (particularly interleukin-6) contribute to inhibition of insulin receptor signaling in target tissues leading to insulin resistance. Consistent with this model, IL-6 levels are 2-3 times higher in the blood of diabetics than controls. We have demonstrated that a family of regulatory proteins, SOCS (Suppressors of Cytokine Signaling) proteins, are induced by IL-6 and other inflammatory cytokines in liver cells. SOCS proteins appear to bind to the components of the insulin receptor signaling pathway and inhibit insulin action. Thus, we propose the inflammatory environment of obesity increases expression of SOCS3 leading to insulin resistance. We are currently testing this model of obesity-dependent insulin resistance at the cellular level and with experimental animals.

The obese, type 2 diabetic has twice the risk of osteoarthritis when compared to a non-obese, non-diabetic individual. The traditional explanation for this risk is the increased bio-mechanical stress on the joint as a consequence of increased body weight. In another area of our lab's research, we have proposed an alternate explanation that attributes at least some of the progression of osteoarthritis in this population to metabolic dysregulation and chronic inflammation that is a hallmark of obesity-mediated diabetes. Recent investigations in our lab using diet-induced obese mice have provided experimental evidence to support a metabolic component to accelerated osteoarthritis progression in obesity-mediated diabetes. Ongoing investigations with genetic and dietary mouse models as well as in vitro models are being employed to define the metabolic pathways that are involved. Therapeutic modalities are also being investigated.

Patents

Compositions of Hydrolyzed Collagen Peptides and Commensal Microorganisms and Methods Thereof

Issue date: September 07, 2021

Patent #: 11,110,147

Country: United States

Inventors: Christopher W Farnsworth, Robert Mooney, Janne Prawitt, Eric Schott, Michael J Zuscik

Publications

Journal Articles

Favazzo LJ, Gill AL, Farnsworth CW, Mooney RA, Gill SR

Journal of bacteriology.. 2019 May 1201 (9)Epub 04/09/2019.

Moriarty TF, Harris LG, Mooney RA, Wenke JC, Riool M, Zaat SAJ, Moter A, Schaer TP, Khanna N, Kuehl R, Alt V, Montali A, Liu J, Zeiter S, Busscher HJ, Grainger DW, Richards RG

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 February 37 (2):271-287. Epub 02/21/2019.

Farnsworth CW, Schott EM, Benvie A, Kates SL, Schwarz EM, Gill SR, Zuscik MJ, Mooney RA

The Journal of immunology : official journal of the American Association of Immunologists.. 2018 July 15201 (2):560-572. Epub 06/01/2018.

Farnsworth CW, Schott EM, Benvie AM, Zukoski J, Kates SL, Schwarz EM, Gill SR, Zuscik MJ, Mooney RA

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2018 June 36 (6):1614-1623. Epub 01/03/2018.

Schott EM, Farnsworth CW, Grier A, Lillis JA, Soniwala S, Dadourian GH, Bell RD, Doolittle ML, Villani DA, Awad H, Ketz JP, Kamal F, Ackert-Bicknell C, Ashton JM, Gill SR, Mooney RA, Zuscik MJ

JCI insight.. 2018 April 193 (8)Epub 04/19/2018.

Wexler O, Gough MS, Morgan MA, Mack CM, Apostolakos MJ, Doolin KP, Mooney RA, Arning E, Bottiglieri T, Pietropaoli AP

Journal of intensive care medicine.. 2018 January 33 (1):37-47. Epub 09/02/2016.

Farnsworth CW, Schott EM, Jensen SE, Zukoski J, Benvie AM, Refaai MA, Kates SL, Schwarz EM, Zuscik MJ, Gill SR, Mooney RA

Infection and immunity.. 2017 June 85 (6)Epub 05/23/2017.

Dar QA, Schott EM, Catheline SE, Maynard RD, Liu Z, Kamal F, Farnsworth CW, Ketz JP, Mooney RA, Hilton MJ, Jonason JH, Prawitt J, Zuscik MJ

PloS one.. 2017 12 (4):e0174705. Epub 04/06/2017.

Hamada D, Maynard R, Schott E, Drinkwater CJ, Ketz JP, Kates SL, Jonason JH, Hilton MJ, Zuscik MJ, Mooney RA

Arthritis & rheumatology.. 2016 June 68 (6):1392-402. Epub 1900 01 01.

Beier EE, Inzana JA, Sheu TJ, Shu L, Puzas JE, Mooney RA

Environmental health perspectives.. 2015 October 123 (10):935-43. Epub 04/10/2015.

Farnsworth CW, Shehatou CT, Maynard R, Nishitani K, Kates SL, Zuscik MJ, Schwarz EM, Daiss JL, Mooney RA

Infection and immunity.. 2015 June 83 (6):2264-74. Epub 03/23/2015.

Barry CT, Hazard C, Hah Z, Cheng G, Partin A, Mooney RA, Chuang KH, Cao W, Rubens DJ, Parker KJ

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.. 2015 June 34 (6):1123-9. Epub 1900 01 01.

Shu L, Beier E, Sheu T, Zhang H, Zuscik MJ, Puzas EJ, Boyce BF, Mooney RA, Xing L

Calcified tissue international.. 2015 April 96 (4):313-23. Epub 02/13/2015.

Barry CT, Hah Z, Partin A, Mooney RA, Chuang KH, Augustine A, Almudevar A, Cao W, Rubens DJ, Parker KJ

Ultrasound in medicine & biology.. 2014 April 40 (4):704-13. Epub 01/10/2014.

David MA, Jones KH, Inzana JA, Zuscik MJ, Awad HA, Mooney RA

PloS one.. 2014 9 (3):e91234. Epub 03/21/2014.

Brown ML, Yukata K, Farnsworth CW, Chen DG, Awad H, Hilton MJ, O'Keefe RJ, Xing L, Mooney RA, Zuscik MJ

PloS one.. 2014 9 (6):e99656. Epub 06/09/2014.

Shi J, Liang Q, Wang Y, Mooney R, Boyce B, Xing L

Biotechnic & histochemistry : official publication of the Biological Stain Commission.. 2013 November 88 (8):428-39. Epub 11/23/2012.

Inzana JA, Kung M, Shu L, Hamada D, Xing LP, Zuscik MJ, Awad HA, Mooney RA

Bone.. 2013 November 57 (1):174-83. Epub 08/14/2013.

Mirando AJ, Liu Z, Moore T, Lang A, Kohn A, Osinski AM, O'Keefe RJ, Mooney RA, Zuscik MJ, Hilton MJ

Arthritis and rheumatism.. 2013 October 65 (10):2623-33. Epub 1900 01 01.

Curtin WM, Menegus MA, Patru MM, Peterson CJ, Metlay LA, Mooney RA, Stanwood NL, Scheible AL, Dorgan A

Fetal diagnosis and therapy.. 2013 33 (2):133-6. Epub 10/11/2012.

Barry CT, Mills B, Hah Z, Mooney RA, Ryan CK, Rubens DJ, Parker KJ

Ultrasound in medicine & biology.. 2012 February 38 (2):175-82. Epub 12/16/2011.

Clementi AH, Gaudy AM, Zimmers TA, Koniaris LG, Mooney RA

Metabolism: clinical and experimental.. 2011 November 60 (11):1610-9. Epub 05/31/2011.

Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ

Science translational medicine.. 2011 September 213 (101):101ra93. Epub 1900 01 01.

Gough MS, Morgan MA, Mack CM, Darling DC, Frasier LM, Doolin KP, Apostolakos MJ, Stewart JC, Graves BT, Arning E, Bottiglieri T, Mooney RA, Frampton MW, Pietropaoli AP

Critical care medicine.. 2011 June 39 (6):1351-8. Epub 1900 01 01.

Mooney RA, Sampson ER, Lerea J, Rosier RN, Zuscik MJ

Arthritis research & therapy.. 2011 13 (6):R198. Epub 12/07/2011.

Gaudy AM, Clementi AH, Campbell JS, Smrcka AV, Mooney RA

The Journal of biological chemistry.. 2010 December 31285 (53):41356-65. Epub 10/26/2010.

Galloway CA, Ashton J, Sparks JD, Mooney RA, Smith HC

Biochimica et biophysica acta.. 2010 November 1802 (11):976-85. Epub 06/09/2010.

Clementi AH, Gaudy AM, Rooijen NV, Pierce RH, Mooney RA

Biochimica et biophysica acta.. 2009 November 1792 (11):1062-72. Epub 08/20/2009.

Thornburg LL, Knight KM, Peterson CJ, McCall KB, Mooney RA, Pressman EK

American journal of obstetrics and gynecology.. 2008 August 199 (2):135.e1-5. Epub 05/02/2008.

Pseudo-anion gap acidosis

Navaneethan, SD; Mooney, RA; James Sloand, J.

NDT Plus. 2008; 1(2): 94-96.

Mooney RA

Journal of applied physiology.. 2007 February 102 (2):816-8; discussion 818-9. Epub 1900 01 01.

Chagnon MJ, Elchebly M, Uetani N, Dombrowski L, Cheng A, Mooney RA, Marette A, Tremblay ML

Canadian journal of physiology and pharmacology.. 2006 July 84 (7):755-63. Epub 1900 01 01.

Klover PJ, Clementi AH, Mooney RA

Endocrinology.. 2005 August 146 (8):3417-27. Epub 04/21/2005.

LeVea CM, Reeder JE, Mooney RA

Experimental cell research.. 2004 July 1297 (1):272-84. Epub 1900 01 01.

Klover PJ, Mooney RA

The international journal of biochemistry & cell biology.. 2004 May 36 (5):753-8. Epub 1900 01 01.

Baliff JP, Mooney RA

American journal of clinical pathology.. 2003 December 120 Suppl :S14-24. Epub 1900 01 01.

Klover PJ, Zimmers TA, Koniaris LG, Mooney RA

Diabetes.. 2003 November 52 (11):2784-9. Epub 1900 01 01.

Arnold GL, Hyman SL, Mooney RA, Kirby RS

Journal of autism and developmental disorders.. 2003 August 33 (4):449-54. Epub 1900 01 01.

Pearce DA, McCall K, Mooney RA, Chattopadhyay S, Curran TM

Clinica chimica acta; international journal of clinical chemistry.. 2003 June 332 (1-2):145-8. Epub 1900 01 01.

Polliotti BM, Fry AG, Saller DN, Mooney RA, Cox C, Miller RK

Obstetrics and gynecology.. 2003 June 101 (6):1266-74. Epub 1900 01 01.

Senn JJ, Klover PJ, Nowak IA, Zimmers TA, Koniaris LG, Furlanetto RW, Mooney RA

The Journal of biological chemistry.. 2003 April 18278 (16):13740-6. Epub 01/30/2003.

Mooney RA, LeVea CM

Current topics in medicinal chemistry.. 2003 3 (7):809-19. Epub 1900 01 01.

Senn JJ, Klover PJ, Nowak IA, Mooney RA

Diabetes.. 2002 December 51 (12):3391-9. Epub 1900 01 01.

Symons JR, LeVea CM, Mooney RA

The Biochemical journal.. 2002 July 15365 (Pt 2):513-9. Epub 1900 01 01.

Mooney RA, Senn J, Cameron S, Inamdar N, Boivin LM, Shang Y, Furlanetto RW

The Journal of biological chemistry.. 2001 July 13276 (28):25889-93. Epub 05/07/2001.

Levea CM, Mcgary CT, Symons JR, Mooney RA

Breast cancer research and treatment.. 2000 November 64 (2):221-8. Epub 1900 01 01.

Bleyle LA, Peng Y, Ellis C, Mooney RA

Cellular signalling.. 1999 October 11 (10):719-25. Epub 1900 01 01.

Hostetler MA, Arnold GL, Mooney R, Bennett MJ, Rinaldo P, Roe CR

Annals of emergency medicine.. 1999 September 34 (3):394-8. Epub 1900 01 01.

Saller DN, Canick JA, Kellner LH, Rose NC, Garza J, French CA, Mooney RA

American journal of obstetrics and gynecology.. 1997 October 177 (4):879-81. Epub 1900 01 01.

Phung TL, Mooney RA, Kulas DT, Sparks CE, Sparks JD

Biochemical and biophysical research communications.. 1997 August 18237 (2):367-71. Epub 1900 01 01.

Mooney RA, Kulas DT, Bleyle LA, Novak JS

Biochemical and biophysical research communications.. 1997 June 27235 (3):709-12. Epub 1900 01 01.

Kulas DT, Goldstein BJ, Mooney RA

The Journal of biological chemistry.. 1996 January 12271 (2):748-54. Epub 1900 01 01.

Kulas DT, Freund GG, Mooney RA

The Journal of biological chemistry.. 1996 January 12271 (2):755-60. Epub 1900 01 01.

Mooney RA, Arvan DA, Saller DN, French CA, Peterson CJ

Obstetrics and gynecology.. 1995 December 86 (6):900-5. Epub 1900 01 01.

Kulas DT, Zhang WR, Goldstein BJ, Furlanetto RW, Mooney RA

The Journal of biological chemistry.. 1995 February 10270 (6):2435-8. Epub 1900 01 01.

Freund GG, Wittig JG, Mooney RA

Biochemical and biophysical research communications.. 1995 January 5206 (1):272-8. Epub 1900 01 01.

Way BA, Mooney RA

Molecular and cellular biochemistry.. 1994 October 26139 (2):167-75. Epub 1900 01 01.

Mooney RA, Peterson CJ, French CA, Saller DN, Arvan DA

Obstetrics and gynecology.. 1994 August 84 (2):298-303. Epub 1900 01 01.

Freund GG, Kulas DT, Way BA, Mooney RA

Cancer research.. 1994 June 1554 (12):3179-85. Epub 1900 01 01.

Way BA, Mooney RA

The Journal of biological chemistry.. 1993 December 15268 (35):26409-15. Epub 1900 01 01.

Freund GG, Kulas DT, Mooney RA

The Journal of immunology : official journal of the American Association of Immunologists.. 1993 August 15151 (4):1811-20. Epub 1900 01 01.

Mooney RA, Freund GG, Way BA, Bordwell KL

The Journal of biological chemistry.. 1992 November 25267 (33):23443-6. Epub 1900 01 01.

Mooney RA, Bordwell KL

The Journal of biological chemistry.. 1992 July 15267 (20):14054-60. Epub 1900 01 01.

Mooney RA, Bordwell KL

Endocrinology.. 1992 March 130 (3):1533-8. Epub 1900 01 01.

Wilbur DC, Willis J, Mooney RA, Fallon MA, Moynes R, di Sant'Agnese PA

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 1992 January 5 (1):79-84. Epub 1900 01 01.

Mooney RA, Bordwell KL

The Biochemical journal.. 1991 March 1274 ( Pt 2) (Pt 2):433-8. Epub 1900 01 01.

Maternal serum alpha-fetoprotein screening (MSAFP): A model program for clinical practice, education, and research in Pathology.

Arvan, DA; Mooney, RA.

Il Patologo Clinico. 1990; 9: 898-908.

Davis NS, DiSant'Agnese PA, Ewing JF, Mooney RA

The Journal of urology.. 1989 September 142 (3):884-8. Epub 1900 01 01.

Mooney RA, Green DA

Biochemical and biophysical research communications.. 1989 August 15162 (3):1200-6. Epub 1900 01 01.

Mooney RA, Anderson DL

The Journal of biological chemistry.. 1989 April 25264 (12):6850-7. Epub 1900 01 01.

Mooney RA, Bordwell KL, Luhowskyj S, Casnellie JE

Endocrinology.. 1989 January 124 (1):422-9. Epub 1900 01 01.

Amatruda JM, Vallone BB, Schuster T, Mooney RA

The Diabetes educator.. 1989 15 (5):435-9. Epub 1900 01 01.

Mayer TK, Mooney RA

Clinica chimica acta; international journal of clinical chemistry.. 1988 February 29172 (1):1-33. Epub 1900 01 01.

Mooney RA, McGorty BL, French CA, Arvan DA

Clinica chimica acta; international journal of clinical chemistry.. 1988 February 15171 (2-3):325-31. Epub 1900 01 01.

Mooney RA

Methods in enzymology.. 1988 159 :193-202. Epub 1900 01 01.

Mooney RA, Swicegood CL, Marx RB

Endocrinology.. 1986 November 119 (5):2240-8. Epub 1900 01 01.

Lee LA, Mooney RA, Woolf PD

Clinical chemistry.. 1986 May 32 (5):797-800. Epub 1900 01 01.

Mooney RA, McDonald JM

The International journal of biochemistry. 1986 18 (8):713-8. Epub 1900 01 01.

Mooney RA, Ebersohl RD, McDonald JM

The Journal of biological chemistry.. 1984 June 25259 (12):7701-4. Epub 1900 01 01.

Mooney RA, McDonald JM

The International journal of biochemistry. 1984 16 (1):55-9. Epub 1900 01 01.

Mooney RA, Ebersohl RD, McDonald JM

European journal of biochemistry. 1983 November 15136 (3):603-8. Epub 1900 01 01.

Mooney RA, Smith CH, Zarkowsky HS

The Journal of pediatrics.. 1983 August 103 (2):262-5. Epub 1900 01 01.

Mooney RA, Lane MD

European journal of biochemistry. 1982 January 121 (2):281-7. Epub 1900 01 01.

McDonald JM, Chan KM, Goewert RR, Mooney RA, Pershadsingh HA

Annals of the New York Academy of Sciences.. 1982 402 :381-401. Epub 1900 01 01.

Mooney RA, Lane MD

The Journal of biological chemistry.. 1981 November 25256 (22):11724-33. Epub 1900 01 01.

Lane MD, Mooney RA

Current topics in cellular regulation. 1981 18 :221-42. Epub 1900 01 01.

Clinkenbeard KD, Reed WD, Mooney RA, Lane MD

The Journal of biological chemistry.. 1975 April 25250 (8):3108-16. Epub 1900 01 01.