Terry W. Wright, Ph.D.
Contact
Terry W. Wright, Ph.D.
About Me
Faculty Appointments
Associate Professor - Department of Pediatrics, Infectious Diseases (SMD)
Associate Professor - Department of Microbiology and Immunology (SMD) - Joint
Credentials
Post-doctoral Training & Residency
Pediatrics Postdoctoral Training, Division of Neonatology, University of Rochester School of Medicine and Dentistry, Rochester, NY 1995 - 1997
Education
PhD | University of Rochester School of Medicine and Dentistry. Microbiology and Immunology. 1995
MS | University of Rochester School of Medicine and Dentistry. Microbiology and Immunology. 1992
BS | Rochester Institute of Technology. Biotechnology. 1990
Awards
American Society for Microbiology Sustaining Membership Travel Award. 1994
Research
1) Pneumocystis carinii biology
2) Pathogenesis of lung injury during Pneumocystis carinii pneumonia.
The rapid clearance of bacterial and fungal pathogens is essential to preserve the delicate structure and critical function of the lung. The...
1) Pneumocystis carinii biology
2) Pathogenesis of lung injury during Pneumocystis carinii pneumonia.
The rapid clearance of bacterial and fungal pathogens is essential to preserve the delicate structure and critical function of the lung. The opportunistic pathogen, Pneumocystis carinii, colonizes the alveolar epithelium of patients suffering from a variety of immunodeficiencies, including AIDS. Dr. Wright's laboratory uses an immunologically-reconstituted scid mouse model of Pneumocystis carinii pneumonia (PCP) to study the host response to infection. Scid mice lack functional lymphocytes and therefore develop active P. carinii infections. However, the adoptive transfer of congenic spleen cells, including CD4+ T lymphocytes, to P. carinii-infected scid mice results in inflammatory cell recruitment to sites of infection and organism clearance. They are now examining the earliest molecular signals (including cytokine and chemokine expression) produced at epithelial sites of P. carinii colonization, to determine which cell types and which soluble mediators are involved in targeting inflammatory cell recruitment. These studies will not only further our understanding of PCP, but may also provide insight into general mechanisms of lung defense.
In addition, they are examining the role of pulmonary inflammation in the pathology of PCP. As stated above, an intense CD4+ T lymphocyte-dependent inflammatory response is mounted at sites of infection in reconstituted scid mice. In many cases this inflammatory response is productive, and serves to resolve the infection. However, under certain circumstances the inflammatory response may actually contribute to the pulmonary injury and respiratory impairment observed in P. carinii pneumonia. They have begun studies using physiological and molecular measurements of lung injury to assess the in vivo role of P. carinii driven inflammation in PCP. They also plan to test specific anti-inflammatory agents to manipulate various aspects of the inflammatory response to determine the effect on lung injury. These studies will help define the role of inflammation in PCP, and further our understanding of pulmonary immunology.
Patents
Polypeptides and Immunogenic Conjugates Capable of Inducing Antibodies Against Pathogens, and Uses Thereof
Issue date: October 19, 2010
Patent #: 7,815,918
Country: United States
Inventors: Francis Gigliotti, Constantine G Haidaris, Patricia J Simpson-Haidaris, Jesse Wells, Terry W Wright
Optimized Antigens of Pneumocystis and Use Thereof
Issue date: December 06, 2016
Patent #: 9,512,189
Country: United States
Inventors: Francis Gigliotti, Constantine G Haidaris, Patricia J Simpson-Haidaris, Terry W Wright
Publications
Journal Articles
Bhagwat SP, Gigliotti F, Wang J, Wang Z, Notter RH, Murphy PS, Rivera-Escalera F, Malone J, Jordan MB, Elliott MR, Wright TW
Frontiers in immunology.. 2018 9 :2131. Epub 09/19/2018.
Zhang ZQ, Wang J, Hoy Z, Keegan A, Gigliotti F, Wright T
Infection and immunity.. 2015 December 83 (12):4594-603. Epub 09/14/2015.
Bello-Irizarry SN, Wang J, Johnston CJ, Gigliotti F, Wright TW
The Journal of immunology : official journal of the American Association of Immunologists.. 2014 January 1192 (1):282-92. Epub 11/29/2013.
Perez-Nazario N, Rangel-Moreno J, O'Reilly MA, Pasparakis M, Gigliotti F, Wright TW
The Journal of immunology : official journal of the American Association of Immunologists.. 2013 November 1191 (9):4720-30. Epub 09/27/2013.
Kulkarni AA, Thatcher TH, Hsiao HM, Olsen KC, Kottmann RM, Morrissette J, Wright TW, Phipps RP, Sime PJ
PloS one.. 2013 8 (5):e63798. Epub 05/31/2013.
Bello-Irizarry SN, Wang J, Olsen K, Gigliotti F, Wright TW
Infection and immunity.. 2012 November 80 (11):3912-20. Epub 08/27/2012.
Gigliotti F, Wright TW
PLoS pathogens.. 2012 8 (11):e1003025. Epub 11/29/2012.
Montgomery SL, Mastrangelo MA, Habib D, Narrow WC, Burrell SA, Wright TW, Bowers WJ
The American journal of pathology.. 2011 October 179 (4):2053-70. Epub 08/09/2011.
Wang J, Wright TW, Gigliotti F
Interdisciplinary perspectives on infectious diseases. 2011 2011 :918038. Epub 08/29/2011.
Wang J, Gigliotti F, Bhagwat SP, George TC, Wright TW
PLoS pathogens.. 2010 August 196 (8):e1001058. Epub 08/19/2010.
Chess PR, Benson RP, Maniscalco WM, Wright TW, O'Reilly MA, Johnston CJ
Experimental lung research.. 2010 August 36 (6):331-41. Epub 1900 01 01.
Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB
Virology.. 2010 May 10400 (2):224-32. Epub 02/25/2010.
Bhagwat SP, Wright TW, Gigliotti F
The Journal of immunology : official journal of the American Association of Immunologists.. 2010 January 1184 (1):497-502. Epub 11/30/2009.
Pryhuber GS, Huyck HL, Bhagwat S, O'Reilly MA, Finkelstein JN, Gigliotti F, Wright TW
The Journal of immunology : official journal of the American Association of Immunologists.. 2008 July 15181 (2):1409-19. Epub 1900 01 01.
Wang J, Gigliotti F, Bhagwat SP, Maggirwar SB, Wright TW
American journal of physiology. Lung cellular and molecular physiology.. 2007 June 292 (6):L1495-505. Epub 02/16/2007.
Bhagwat SP, Gigliotti F, Xu H, Wright TW
American journal of physiology. Lung cellular and molecular physiology.. 2006 December 291 (6):L1256-66. Epub 08/04/2006.
Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco WM, Finkelstein JN, O'Reilly MA
American journal of physiology. Lung cellular and molecular physiology.. 2006 November 291 (5):L1101-11. Epub 07/21/2006.
Gigliotti F, Crow EL, Bhagwat SP, Wright TW
Infection and immunity.. 2006 November 74 (11):6310-6. Epub 08/28/2006.
Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, O'Reilly MA
The American journal of pathology.. 2006 June 168 (6):1838-47. Epub 1900 01 01.
Wells J, Haidaris CG, Wright TW, Gigliotti F
Infection and immunity.. 2006 April 74 (4):2446-8. Epub 1900 01 01.
Wells J, Haidaris CG, Wright TW, Gigliotti F
Infection and immunity.. 2006 January 74 (1):390-3. Epub 1900 01 01.
Gigliotti F, Wright TW
Expert reviews in molecular medicine.. 2005 November 147 (26):1-16. Epub 11/14/2005.
Wang Z, Foye A, Chang Y, Chess PR, Wright TW, Bhagwat S, Gigliotti F, Notter RH
American journal of physiology. Lung cellular and molecular physiology.. 2005 June 288 (6):L1124-31. Epub 1900 01 01.
Wang J, Gigliotti F, Maggirwar S, Johnston C, Finkelstein JN, Wright TW
Infection and immunity.. 2005 May 73 (5):2766-77. Epub 1900 01 01.
Disney MD, Stephenson R, Wright TW, Haidaris CG, Turner DH, Gigliotti F
Antimicrobial agents and chemotherapy.. 2005 April 49 (4):1326-30. Epub 1900 01 01.
Swain SD, Wright TW, Degel PM, Gigliotti F, Harmsen AG
Infection and immunity.. 2004 October 72 (10):5722-32. Epub 1900 01 01.
Wright TW, Pryhuber GS, Chess PR, Wang Z, Notter RH, Gigliotti F
The Journal of immunology : official journal of the American Association of Immunologists.. 2004 February 15172 (4):2511-21. Epub 1900 01 01.
Gigliotti F, Harmsen AG, Wright TW
Infection and immunity.. 2003 July 71 (7):3852-6. Epub 1900 01 01.
Staversky RJ, Watkins RH, Wright TW, Hernady E, LoMonaco MB, D'Angio CT, Williams JP, Maniscalco WM, O'Reilly MA
The American journal of pathology.. 2002 October 161 (4):1383-93. Epub 1900 01 01.
Gigliotti F, Haidaris CG, Wright TW, Harmsen AG
Infection and immunity.. 2002 March 70 (3):1069-74. Epub 1900 01 01.
Wright TW, Notter RH, Wang Z, Harmsen AG, Gigliotti F
Infection and immunity.. 2001 February 69 (2):758-64. Epub 1900 01 01.
Lee LH, Gigliotti F, Wright TW, Simpson-Haidaris PJ, Weinberg GA, Haidaris CG
Gene.. 2000 January 25242 (1-2):141-50. Epub 1900 01 01.
Wright TW, Gigliotti F, Finkelstein JN, McBride JT, An CL, Harmsen AG
The Journal of clinical investigation.. 1999 November 104 (9):1307-17. Epub 1900 01 01.
Wright TW, Johnston CJ, Harmsen AG, Finkelstein JN
Infection and immunity.. 1999 July 67 (7):3452-60. Epub 1900 01 01.
Simpson-Haidaris PJ, Courtney MA, Wright TW, Goss R, Harmsen A, Gigliotti F
Infection and immunity.. 1998 September 66 (9):4431-9. Epub 1900 01 01.
Johnston CJ, Stripp BR, Piedbeouf B, Wright TW, Mango GW, Reed CK, Finkelstein JN
Experimental lung research.. 1998 24 (2):189-202. Epub 1900 01 01.
Johnston CJ, Wright TW, Rubin P, Finkelstein JN
Experimental lung research.. 1998 24 (3):321-37. Epub 1900 01 01.
D'Angio CT, Johnston CJ, Wright TW, Reed CK, Finkelstein JN
Experimental lung research.. 1998 24 (5):685-702. Epub 1900 01 01.
Wright TW, Johnston CJ, Harmsen AG, Finkelstein JN
American journal of respiratory cell and molecular biology.. 1997 October 17 (4):491-500. Epub 1900 01 01.
Johnston CJ, Wright TW, Reed CK, Finkelstein JN
Experimental lung research.. 1997 23 (6):537-52. Epub 1900 01 01.
Wright TW, Gigliotti F, Haidaris CG, Simpson-Haidaris PJ
Gene.. 1995 December 29167 (1-2):185-9. Epub 1900 01 01.
Simpson-Haidaris PJ, Wright TW, Earnest BJ, Hui Z, Neroni LA, Courtney MA
Gene.. 1995 December 29167 (1-2):273-8. Epub 1900 01 01.
Wright TW, Bissoondial TY, Haidaris CG, Gigliotti F, Haidaris PJ
DNA research : an international journal for rapid publication of
Wright TW, Simpson-Haidaris PJ, Gigliotti F, Harmsen AG, Haidaris CG
Infection and immunity.. 1994 May 62 (5):1513-9. Epub 1900 01 01.
Lawrence SO, Wright TW, Francis CW, Fay PJ, Haidaris PJ
Blood.. 1993 October 1582 (8):2406-13. Epub 1900 01 01.
Gigliotti F, Haidaris PJ, Haidaris CG, Wright TW, Van der Meid KR
The Journal of infectious diseases.. 1993 July 168 (1):191-4. Epub 1900 01 01.
Haidaris PJ, Wright TW, Gigliotti F, Fallon MA, Whitbeck AA, Haidaris CG
Molecular microbiology.. 1993 March 7 (5):647-56. Epub 1900 01 01.
Haidaris PJ, Wright TW, Gigliotti F, Haidaris CG
The Journal of infectious diseases.. 1992 November 166 (5):1113-23. Epub 1900 01 01.
Gigliotti F
The Journal of protozoology. 1991 38 (6):4S-5S. Epub 1900 01 01.
Haidaris CG, Wright TW, Gigliotti F, Haidaris PJ
The Journal of protozoology. 1991 38 (6):5S-6S. Epub 1900 01 01.
Books
Pneumocystis carinii Pneumonia (2005)
Chapter: Mechanisms of lung damage
Authors: Wright TW, Harmsen AG, Gigliotti F
Publisher: Marcel Dekker, Inc., New York, NY 2005
Pneumocystis carinii Pneumonia (2005)
Chapter: Antibodies and other non-T cell defenses
Authors: Gigliotti F, Haidaris CG, Harmsen AG, Wright TW
Publisher: Marcel Dekker, Inc., New York, NY 2005
Principles and Practice of Pediatric Infectious Diseases (2003)
Chapter: Pneumocystis carinii
Authors: Gigliotti F, Wright T
Publisher: Churchill Livingstone, Philadelphia, PA 2003