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Robert T. Dirksen, Ph.D.

Robert T. Dirksen, Ph.D.

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About Me

Faculty Appointments

Professor - Department of Pharmacology and Physiology (SMD)

Chair - Department of Pharmacology and Physiology (SMD)

Lewis Pratt Ross Professorship of Pharmacology and Physiology - Department of Pharmacology and Physiology (SMD)

Credentials

Post-doctoral Training & Residency

Postdoctoral Fellow, Colorado State University, Fort Collins, CO (Mentor: Kurt G. Beam, Ph. D.) 1991 - 1996

Education

PhD | University of Rochester. Pharmacology. 1991

MS | University of Rochester. Pharmacology. 1988

BS | University of Notre Dame. Biology. 1985

Awards

Chair. 2015

Vice-Chair. 2012

Graduate Student Society Faculty Mentoring Award. 2002

Research

Dr. Dirksen directs a multi-disciplinary research program focused on elucidating disease mechanisms and advancing treatment for muscular dystrophy and heart disease. The laboratory investigates the pathophysiological mechanisms by which defects in the proper control of intracellular calcium signalin...
Dr. Dirksen directs a multi-disciplinary research program focused on elucidating disease mechanisms and advancing treatment for muscular dystrophy and heart disease. The laboratory investigates the pathophysiological mechanisms by which defects in the proper control of intracellular calcium signaling lead to muscle dysfunction and disease. Current projects involve elucidating the cellular mechanisms by which muscle function is controlled by proteins involved in coordinating: 1) excitation-contraction coupling, 2) store-operated calcium entry, and 3) mitochondrial calcium uptake and energy production, as well as 4) the molecular mechanisms for skeletal and cardiac muscle dysfunction in myotonic dystrophy.

Publications

Journal Articles

Peng W, Chung KB, Lawrence BP, O'Banion MK, Dirksen RT, Wojtovich AP, Onukwufor JO

Free radical biology & medicine.. 2024 September 22 Epub 09/22/2024.

van de Camp SAJH, Stinissen L, Huseth A, Simon B, Ryan J, Sarkozy A, Van Petegem F, Goldberg MF, Jungbluth H, Böhm J, Oortwijn W, Dirksen RT, Voermans NC

Journal of neuromuscular diseases.. 2024 August 14 Epub 08/14/2024.

Peng W, Chung KB, Lawrence BP, O'Banion MK, Dirksen RT, Wojtovich AP, Onukwufor JO

bioRxiv : the preprint server for biology.. 2024 August 9 Epub 08/09/2024.

Di Fonso A, Serano M, He M, Leigh J, Rastelli G, Dirksen RT, Protasi F, Pietrangelo L

Biomedicines.. 2024 July 2412 (8)Epub 07/24/2024.

Asantewaa G, Tuttle ET, Ward NP, Kang YP, Kim Y, Kavanagh ME, Girnius N, Chen Y, Rodriguez K, Hecht F, Zocchi M, Smorodintsev-Schiller L, Scales TQ, Taylor K, Alimohammadi F, Duncan RP, Sechrist ZR, Agostini-Vulaj D, Schafer XL, Chang H, Smith ZR, O'Connor TN, Whelan S, Selfors LM, Crowdis J, Gray GK, Bronson RT, Brenner D, Rufini A, Dirksen RT, Hezel AF, Huber AR, Munger J, Cravatt BF, Vasiliou V, Cole CL, DeNicola GM, Harris IS

Nature communications.. 2024 July 2115 (1):6152. Epub 07/21/2024.

Endo Y, Groom L, Wang SM, Pannia E, Griffiths NW, Van Gennip JLM, Ciruna B, Laporte J, Dirksen RT, Dowling JJ

Human molecular genetics.. 2024 January 2033 (3):254-269. Epub 1900 01 01.

Strohm AO, O'Connor TN, Oldfield S, Young S, Hammond C, McCall M, Dirksen RT, Majewska AK

Journal of applied physiology.. 2024 January 1136 (1):89-108. Epub 11/16/2023.

O'Connor TN, Zhao N, Orciuoli HM, Brasile A, Pietrangelo L, He M, Groom L, Leigh J, Mahamed Z, Liang C, Malik S, Protasi F, Dirksen RT

bioRxiv : the preprint server for biology.. 2023 September 29 Epub 09/29/2023.

Magyar ZÉ, Hevesi J, Groom L, Dirksen RT, Almássy J

Scientific reports.. 2023 September 513 (1):14659. Epub 09/05/2023.

Asantewaa G, Tuttle ET, Ward NP, Kang YP, Kim Y, Kavanagh ME, Girnius N, Chen Y, Duncan R, Rodriguez K, Hecht F, Zocchi M, Smorodintsev-Schiller L, Scales TQ, Taylor K, Alimohammadi F, Sechrist ZR, Agostini-Vulaj D, Schafer XL, Chang H, Smith Z, O'Connor TN, Whelan S, Selfors LM, Crowdis J, Gray GK, Bronson RT, Brenner D, Rufini A, Dirksen RT, Hezel AF, Huber AR, Munger J, Cravatt BF, Vasiliou V, Cole CL, DeNicola GM, Harris IS

bioRxiv : the preprint server for biology.. 2023 February 11 Epub 02/11/2023.

Zhao N, Michelucci A, He M, Malik S, Pietrangelo L, Boncompagni S, Protasi F, Dirksen RT

Biophysical journal.. 2023 February 10122 (3S1):377a. Epub 1900 01 01.

O'Connor TN, van den Bersselaar LR, Chen YS, Nicolau S, Simon B, Huseth A, Todd JJ, Van Petegem F, Sarkozy A, Goldberg MF, Voermans NC, Dirksen RT,

Journal of neuromuscular diseases.. 2023 10 (1):135-154. Epub 1900 01 01.

Michelucci A, Pietrangelo L, Rastelli G, Protasi F, Dirksen RT, Boncompagni S

The Journal of general physiology.. 2022 December 5154 (12)Epub 10/12/2022.

Johnston JJ, Dirksen RT, Girard T, Hopkins PM, Kraeva N, Ognoon M, Radenbaugh KB, Riazi S, Robinson RL, Saddic Iii LA, Sambuughin N, Saxena R, Shepherd S, Stowell K, Weber J, Yoo S, Rosenberg H, Biesecker LG

Human molecular genetics.. 2022 November 2831 (23):4087-4093. Epub 1900 01 01.

O'Connor TN, Kallenbach JG, Chakkalakal JV, Dirksen RT

The Journal of general physiology.. 2022 September 5154 (9)Epub 11/12/2021.

Wei-LaPierre L, Groom L, Dirksen RT

The Journal of general physiology.. 2022 September 5154 (9)Epub 12/15/2021.

García-Castañeda M, Michelucci A, Zhao N, Malik S, Dirksen RT

The Journal of general physiology.. 2022 September 5154 (9)Epub 08/08/2022.

Dirksen RT, Eisner DA, Ríos E, Sipido KR

The Journal of general physiology.. 2022 September 5154 (9)Epub 08/19/2022.

Endo Y, Groom L, Celik A, Kraeva N, Lee CS, Jung SY, Gardner L, Shaw MA, Hamilton SL, Hopkins PM, Dirksen RT, Riazi S, Dowling JJ

Nature communications.. 2022 June 1313 (1):3403. Epub 06/13/2022.

Espinosa KG, Geissah S, Groom L, Volpatti J, Scott IC, Dirksen RT, Zhao M, Dowling JJ

Disease models & mechanisms.. 2022 May 115 (5)Epub 05/09/2022.

O'Connor TN, Kallenbach JG, Orciuoli HM, Paris ND, Bachman JF, Johnston CJ, Hernady E, Williams JP, Dirksen RT, Chakkalakal JV

Skeletal muscle. 2022 April 1212 (1):8. Epub 04/12/2022.

Onukwufor JO, Dirksen RT, Wojtovich AP

Antioxidants.. 2022 March 3111 (4)Epub 03/31/2022.

Garcia-Hernandez ML, Rangel-Moreno J, Garcia-Castaneda M, Kenney HM, Paine A, Thullen M, Anandarajah AP, Schwarz EM, Dirksen RT, Ritchlin CT

Frontiers in immunology.. 2022 13 :1026574. Epub 11/07/2022.

Johnston JJ, Dirksen RT, Girard T, Gonsalves SG, Hopkins PM, Riazi S, Saddic LA, Sambuughin N, Saxena R, Stowell K, Weber J, Rosenberg H, Biesecker LG

Genetics in medicine : official journal of the American College of Medical Genetics.. 2021 July 23 (7):1288-1295. Epub 03/25/2021.

Michelucci A, Liang C, Protasi F, Dirksen RT

Metabolites.. 2021 June 2811 (7)Epub 06/28/2021.

Baker ML, Dirksen RT, Hamilton SL

Cell calcium.. 2021 April 1997 :102412. Epub 04/19/2021.

Biesecker LG, Dirksen RT, Girard T, Hopkins PM, Riazi S, Rosenberg H, Stowell K, Weber J

Anesthesiology.. 2020 December 1133 (6):1277-1282. Epub 1900 01 01.

Lawal TA, Todd JJ, Witherspoon JW, Bönnemann CG, Dowling JJ, Hamilton SL, Meilleur KG, Dirksen RT

Skeletal muscle. 2020 November 1610 (1):32. Epub 11/16/2020.

Wang HJ, Lee CS, Yee RSZ, Groom L, Friedman I, Babcock L, Georgiou DK, Hong J, Hanna AD, Recio J, Choi JM, Chang T, Agha NH, Romero J, Sarkar P, Voermans N, Gaber MW, Jung SY, Baker ML, Pautler RG, Dirksen RT, Riazi S, Hamilton SL

Nature communications.. 2020 October 911 (1):5099. Epub 10/09/2020.

Michelucci A, Boncompagni S, Pietrangelo L, Takano T, Protasi F, Dirksen RT

The Journal of general physiology.. 2020 October 5152 (10)Epub 1900 01 01.

Volpatti JR, Endo Y, Knox J, Groom L, Brennan S, Noche R, Zuercher WJ, Roy P, Dirksen RT, Dowling JJ

eLife.. 2020 March 309 Epub 03/30/2020.

Kim JK, Jha NN, Feng Z, Faleiro MR, Chiriboga CA, Wei-Lapierre L, Dirksen RT, Ko CP, Monani UR

The Journal of clinical investigation.. 2020 March 2130 (3):1271-1287. Epub 1900 01 01.

Tylock KM, Auerbach DS, Tang ZZ, Thornton CA, Dirksen RT

The Journal of general physiology.. 2020 February 3152 (2)Epub 1900 01 01.

Sangkuhl K, Dirksen RT, Alvarellos ML, Altman RB, Klein TE

Pharmacogenetics and genomics.. 2020 February 30 (2):34-44. Epub 1900 01 01.

Michelucci A, Boncompagni S, Pietrangelo L, García-Castañeda M, Takano T, Malik S, Dirksen RT, Protasi F

eLife.. 2019 October 288 Epub 10/28/2019.

Brennan S, Garcia-Castañeda M, Michelucci A, Sabha N, Malik S, Groom L, Wei-La-Pierre L, Dowling JJ, Dirksen RT

Human molecular genetics.. 2019 September 1528 (18):3024-3036. Epub 1900 01 01.

Yue L, Talukder MAH, Gurjar A, Lee JI, Noble M, Dirksen RT, Chakkalakal J, Elfar JC

Muscle & nerve.. 2019 August 60 (2):192-201. Epub 05/30/2019.

Dirksen RT, Wang W, Sheu SS

Archives of biochemistry and biophysics.. 2019 July 15669 :31. Epub 05/18/2019.

Wei-LaPierre L, Dirksen RT

The Journal of general physiology.. 2019 June 3151 (6):708-713. Epub 04/22/2019.

Gonsalves SG, Dirksen RT, Sangkuhl K, Pulk R, Alvarellos M, Vo T, Hikino K, Roden D, Klein T, Mark Poler S, Patel S, Caudle KE, Gordon R, Brandom B, Biesecker LG

Clinical pharmacology and therapeutics.. 2019 June 105 (6):1338-1344. Epub 01/24/2019.

Wei-LaPierre L, Ainbinder A, Tylock KM, Dirksen RT

Archives of biochemistry and biophysics.. 2019 April 15665 :122-131. Epub 03/11/2019.

McBride S, Wei-LaPierre L, McMurray F, MacFarlane M, Qiu X, Patten DA, Dirksen RT, Harper ME

Archives of biochemistry and biophysics.. 2019 March 15663 :239-248. Epub 01/16/2019.

Zhang S, Ye D, Ma L, Ren Y, Dirksen RT, Liu X

Journal of dental research.. 2019 February 98 (2):242-249. Epub 11/01/2018.

Dirksen RT, Allen PD, Lopez JR

British journal of anaesthesia.. 2019 January 122 (1):8-9. Epub 11/27/2018.

Michelucci A, García-Castañeda M, Boncompagni S, Dirksen RT

Cell calcium.. 2018 December 76 :101-115. Epub 10/30/2018.

Boncompagni S, Michelucci A, Pietrangelo L, Dirksen RT, Protasi F

Scientific reports.. 2018 November 278 (1):17463. Epub 11/27/2018.

Maani N, Sabha N, Rezai K, Ramani A, Groom L, Eltayeb N, Mavandadnejad F, Pang A, Russo G, Brudno M, Haucke V, Dirksen RT, Dowling JJ

Nature communications.. 2018 November 199 (1):4849. Epub 11/19/2018.

Trembley MA, Quijada P, Agullo-Pascual E, Tylock KM, Colpan M, Dirkx RA, Myers JR, Mickelsen DM, de Mesy Bentley K, Rothenberg E, Moravec CS, Alexis JD, Gregorio CC, Dirksen RT, Delmar M, Small EM

Circulation.. 2018 October 23138 (17):1864-1878. Epub 1900 01 01.

Smith CO, Wang YT, Nadtochiy SM, Miller JH, Jonas EA, Dirksen RT, Nehrke K, Brookes PS

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2018 June 432 (11):fj201800139R. Epub 06/04/2018.

Auerbach DS, Biton Y, Polonsky B, McNitt S, Gross RA, Dirksen RT, Moss AJ

Translational research : the journal of laboratory and clinical medicine.. 2018 January 191 :81-92.e7. Epub 10/20/2017.

Boncompagni S, Michelucci A, Pietrangelo L, Dirksen RT, Protasi F

Scientific reports.. 2017 October 277 (1):14286. Epub 10/27/2017.

Chen W, Koop A, Liu Y, Guo W, Wei J, Wang R, MacLennan DH, Dirksen RT, Chen SRW

The Biochemical journal.. 2017 August 7474 (16):2749-2761. Epub 08/07/2017.

Liu W, Klose A, Forman S, Paris ND, Wei-LaPierre L, Cortés-Lopéz M, Tan A, Flaherty M, Miura P, Dirksen RT, Chakkalakal JV

eLife.. 2017 June 66 Epub 06/06/2017.

Liu X, Ma L, Zhang S, Ren Y, Dirksen RT

Journal of dental research.. 2017 June 96 (6):671-677. Epub 02/16/2017.

Linsley JW, Hsu IU, Groom L, Yarotskyy V, Lavorato M, Horstick EJ, Linsley D, Wang W, Franzini-Armstrong C, Dirksen RT, Kuwada JY

Proceedings of the National Academy of Sciences of the United States of America.. 2017 January 10114 (2):E228-E236. Epub 12/21/2016.

Skov M, Dirksen RT

The Journal of general physiology.. 2017 January 149 (1):49-53. Epub 12/09/2016.

Carrell EM, Coppola AR, McBride HJ, Dirksen RT

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2016 December 30 (12):4109-4119. Epub 09/01/2016.

Auerbach DS, McNitt S, Gross RA, Zareba W, Dirksen RT, Moss AJ

Neurology.. 2016 October 1887 (16):1660-1668. Epub 07/27/2016.

Carrell ST, Carrell EM, Auerbach D, Pandey SK, Bennett CF, Dirksen RT, Thornton CA

Human molecular genetics.. 2016 October 125 (19):4328-4338. Epub 08/13/2016.

Wang W, Gong G, Wang X, Wei-LaPierre L, Cheng H, Dirksen RT, Sheu SS

Antioxidants & redox signaling.. 2016 September 2025 (9):534-49. Epub 07/14/2016.

Ma L, Trinh T, Ren Y, Dirksen RT, Liu X

PloS one.. 2016 11 (10):e0164028. Epub 10/05/2016.

Pietrangelo L, D'Incecco A, Ainbinder A, Michelucci A, Kern H, Dirksen RT, Boncompagni S, Protasi F

Oncotarget.. 2015 November 36 (34):35358-71. Epub 1900 01 01.

Georgiou DK, Dagnino-Acosta A, Lee CS, Griffin DM, Wang H, Lagor WR, Pautler RG, Dirksen RT, Hamilton SL

The Journal of biological chemistry.. 2015 September 25290 (39):23751-65. Epub 08/05/2015.

Liu X, Wang C, Fujita T, Malmstrom HS, Nedergaard M, Ren YF, Dirksen RT

Journal of dental research.. 2015 September 94 (9):1259-66. Epub 06/30/2015.

Michelucci A, Paolini C, Canato M, Wei-Lapierre L, Pietrangelo L, De Marco A, Reggiani C, Dirksen RT, Protasi F

Anesthesiology.. 2015 September 123 (3):603-17. Epub 1900 01 01.

Liu W, Wei-LaPierre L, Klose A, Dirksen RT, Chakkalakal JV

eLife.. 2015 August 274 Epub 08/27/2015.

Lamboley CR, Kake Guena SA, Touré F, Hébert C, Yaddaden L, Nadeau S, Bouchard P, Wei-LaPierre L, Lainé J, Rousseau EC, Frenette J, Protasi F, Dirksen RT, Pape PC

The Journal of general physiology.. 2015 February 145 (2):127-53. Epub 1900 01 01.

Ainbinder A, Boncompagni S, Protasi F, Dirksen RT

Cell calcium.. 2015 January 57 (1):14-24. Epub 11/15/2014.

Lee CS, Dagnino-Acosta A, Yarotskyy V, Hanna A, Lyfenko A, Knoblauch M, Georgiou DK, Poché RA, Swank MW, Long C, Ismailov II, Lanner J, Tran T, Dong K, Rodney GG, Dickinson ME, Beeton C, Zhang P, Dirksen RT, Hamilton SL

Skeletal muscle. 2015 5 :4. Epub 01/29/2015.

Paolini C, Quarta M, Wei-LaPierre L, Michelucci A, Nori A, Reggiani C, Dirksen RT, Protasi F

Skeletal muscle. 2015 5 :10. Epub 04/18/2015.

Rebbeck RT, Willemse H, Groom L, Casarotto MG, Board PG, Beard NA, Dirksen RT, Dulhunty AF

Skeletal muscle. 2015 5 :23. Epub 07/22/2015.

Yarotskyy V, Dirksen RT

Biophysical journal.. 2014 November 4107 (9):2027-36. Epub 1900 01 01.

Riazi S, Kraeva N, Muldoon SM, Dowling J, Ho C, Petre MA, Parness J, Dirksen RT, Rosenberg H

Canadian journal of anaesthesia = Journal canadien d'anesthe?sie.. 2014 November 61 (11):1040-9. Epub 09/05/2014.

Cheng H, Wang W, Wang X, Sheu SS, Dirksen RT, Dong MQ

Nature.. 2014 October 23514 (7523):E14-5. Epub 1900 01 01.

Dowling JJ, Lawlor MW, Dirksen RT

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.. 2014 October 11 (4):773-85. Epub 1900 01 01.

O-Uchi J, Jhun BS, Xu S, Hurst S, Raffaello A, Liu X, Yi B, Zhang H, Gross P, Mishra J, Ainbinder A, Kettlewell S, Smith GL, Dirksen RT, Wang W, Rizzuto R, Sheu SS

Antioxidants & redox signaling.. 2014 August 2021 (6):863-79. Epub 06/25/2014.

Wagner LE, Groom LA, Dirksen RT, Yule DI

Cell calcium.. 2014 August 56 (2):96-107. Epub 06/06/2014.

Goonasekera SA, Davis J, Kwong JQ, Accornero F, Wei-LaPierre L, Sargent MA, Dirksen RT, Molkentin JD

Human molecular genetics.. 2014 July 1523 (14):3706-15. Epub 02/20/2014.

Ram R, Wescott AP, Varandas K, Dirksen RT, Blaxall BC

American journal of physiology. Heart and circulatory physiology.. 2014 January 1306 (1):H154-9. Epub 11/01/2013.

Yarotskyy V, Dirksen RT

Channels.. 2014 8 (4):286-7. Epub 1900 01 01.

Reifler A, Lenk GM, Li X, Groom L, Brooks SV, Wilson D, Bowerson M, Dirksen RT, Meisler MH, Dowling JJ

Skeletal muscle. 2013 September 13 (1):21. Epub 09/01/2013.

Wei-Lapierre L, Gong G, Gerstner BJ, Ducreux S, Yule DI, Pouvreau S, Wang X, Sheu SS, Cheng H, Dirksen RT, Wang W

The Journal of biological chemistry.. 2013 April 12288 (15):10567-77. Epub 03/01/2013.

Kraeva N, Zvaritch E, Rossi AE, Goonasekera SA, Zaid H, Frodis W, Kraev A, Dirksen RT, Maclennan DH, Riazi S

Neuromuscular disorders : NMD.. 2013 February 23 (2):120-32. Epub 11/24/2012.

Lefebvre R, Legrand C, Groom L, Dirksen RT, Jacquemond V

PloS one.. 2013 8 (1):e54042. Epub 01/07/2013.

Yarotskyy V, Protasi F, Dirksen RT

PloS one.. 2013 8 (10):e77633. Epub 10/15/2013.

Wei-Lapierre L, Carrell EM, Boncompagni S, Protasi F, Dirksen RT

Nature communications.. 2013 4 :2805. Epub 1900 01 01.

Yarotskyy V, Dirksen RT

Biophysical journal.. 2012 July 18103 (2):202-11. Epub 07/17/2012.

Sheu SS, Dirksen RT, Pugh EN

The Journal of general physiology.. 2012 June 139 (6):391-3. Epub 1900 01 01.

Wei L, Dirksen RT

The Journal of general physiology.. 2012 June 139 (6):425-34. Epub 1900 01 01.

Tang ZZ, Yarotskyy V, Wei L, Sobczak K, Nakamori M, Eichinger K, Moxley RT, Dirksen RT, Thornton CA

Human molecular genetics.. 2012 March 1521 (6):1312-24. Epub 12/02/2011.

Liu X, Yu L, Wang Q, Pelletier J, Fausther M, Sévigny J, Malmström HS, Dirksen RT, Ren YF

Journal of dental research.. 2012 March 91 (3):261-7. Epub 12/14/2011.

Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, Hamilton SL

Nature medicine.. 2012 January 818 (2):244-51. Epub 01/08/2012.

Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG

Circulation research.. 2012 January 6110 (1):59-70. Epub 11/10/2011.

Loy RE, Lueck JD, Mostajo-Radji MA, Carrell EM, Dirksen RT

PloS one.. 2012 7 (11):e49757. Epub 11/12/2012.

Sheu SS, Dirksen RT, Pugh EN

The Journal of general physiology.. 2011 December 138 (6):563-7. Epub 1900 01 01.

Huang Z, Zhang W, Fang H, Zheng M, Wang X, Xu J, Cheng H, Gong G, Wang W, Dirksen RT, Sheu SS

Free radical biology & medicine.. 2011 November 1551 (10):1937-40. Epub 08/30/2011.

Lefebvre R, Legrand C, González-Rodríguez E, Groom L, Dirksen RT, Jacquemond V

The Journal of physiology.. 2011 November 15589 (Pt 22):5361-82. Epub 10/03/2011.

Rossi AE, Boncompagni S, Wei L, Protasi F, Dirksen RT

American journal of physiology. Cell physiology.. 2011 November 301 (5):C1128-39. Epub 08/17/2011.

Groom L, Muldoon SM, Tang ZZ, Brandom BW, Bayarsaikhan M, Bina S, Lee HS, Qiu X, Sambuughin N, Dirksen RT

Anesthesiology.. 2011 November 115 (5):938-45. Epub 1900 01 01.

Wei L, Salahura G, Boncompagni S, Kasischke KA, Protasi F, Sheu SS, Dirksen RT

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2011 September 25 (9):3068-78. Epub 06/06/2011.

Ryu SY, Beutner G, Kinnally KW, Dirksen RT, Sheu SS

The Journal of biological chemistry.. 2011 June 17286 (24):21324-9. Epub 04/27/2011.

Loy RE, Orynbayev M, Xu L, Andronache Z, Apostol S, Zvaritch E, MacLennan DH, Meissner G, Melzer W, Dirksen RT

The Journal of general physiology.. 2011 January 137 (1):43-57. Epub 12/13/2010.

Tae H, Wei L, Willemse H, Mirza S, Gallant EM, Board PG, Dirksen RT, Casarotto MG, Dulhunty A

Channels.. 2011 5 (2):148-60. Epub 03/01/2011.

Boncompagni S, Loy RE, Dirksen RT, Franzini-Armstrong C

Aging cell.. 2010 December 9 (6):958-70. Epub 10/21/2010.

Lueck JD, Rossi AE, Thornton CA, Campbell KP, Dirksen RT

The Journal of general physiology.. 2010 December 136 (6):597-613. Epub 11/15/2010.

Dirksen RT, Pugh EN

The Journal of general physiology.. 2010 July 136 (1):3-5. Epub 1900 01 01.

Ryu SY, Beutner G, Dirksen RT, Kinnally KW, Sheu SS

FEBS letters.. 2010 May 17584 (10):1948-55. Epub 01/21/2010.

Zhou H, Lillis S, Loy RE, Ghassemi F, Rose MR, Norwood F, Mills K, Al-Sarraj S, Lane RJ, Feng L, Matthews E, Sewry CA, Abbs S, Buk S, Hanna M, Treves S, Dirksen RT, Meissner G, Muntoni F, Jungbluth H

Neuromuscular disorders : NMD.. 2010 March 20 (3):166-73. Epub 01/18/2010.

Wei L, Dirksen RT

Current topics in membranes.. 2010 66 :139-67. Epub 07/25/2010.

Dirksen RT, Bannister RA

The Journal of general physiology.. 2009 December 134 (6):453-5. Epub 1900 01 01.

Wheeler TM, Sobczak K, Lueck JD, Osborne RJ, Lin X, Dirksen RT, Thornton CA

Science.. 2009 July 17325 (5938):336-9. Epub 1900 01 01.

Dirksen RT

The Journal of physiology.. 2009 July 1587 (Pt 13):3139-47. Epub 04/30/2009.

Dainese M, Quarta M, Lyfenko AD, Paolini C, Canato M, Reggiani C, Dirksen RT, Protasi F

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2009 June 23 (6):1710-20. Epub 02/23/2009.

Dirksen RT

Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme.. 2009 June 34 (3):389-95. Epub 1900 01 01.

Fallon JL, Baker MR, Xiong L, Loy RE, Yang G, Dirksen RT, Hamilton SL, Quiocho FA

Proceedings of the National Academy of Sciences of the United States of America.. 2009 March 31106 (13):5135-40. Epub 03/11/2009.

Andronache Z, Hamilton SL, Dirksen RT, Melzer W

Proceedings of the National Academy of Sciences of the United States of America.. 2009 March 17106 (11):4531-6. Epub 02/25/2009.

Kimura T, Lueck JD, Harvey PJ, Pace SM, Ikemoto N, Casarotto MG, Dirksen RT, Dulhunty AF

Cell calcium.. 2009 March 45 (3):264-74. Epub 01/07/2009.

Boncompagni S, Rossi AE, Micaroni M, Beznoussenko GV, Polishchuk RS, Dirksen RT, Protasi F

Molecular biology of the cell.. 2009 February 20 (3):1058-67. Epub 11/26/2008.

Oestreich EA, Malik S, Goonasekera SA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV

The Journal of biological chemistry.. 2009 January 16284 (3):1514-22. Epub 10/27/2008.

Rossi AE, Boncompagni S, Dirksen RT

Exercise and sport sciences reviews.. 2009 January 37 (1):29-35. Epub 1900 01 01.

A recessive CCD mutation in RyR1 (V4849I) increases voltage-gated Ca2+ release and SR Ca2+ release flux following homozygous expression in dyspedic myotubes.

Lyfenko, AD; Schuhmeier, RP; Avila, G; Melzer, W; and Dirksen, RT.

2009; In preparation.

A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ leak in muscle fibers of Y522S RyR1 knock-in mice.

Andronache, Z.; Hamilton, SL; Dirksen, RT; and Melzer, W.

Proc. Natl. Acad. Sci. 2009; In Press.

Anesthetic- and heat-induced sudden death in calsequestrin-1 knockout mice.

Marco, M; Quarta, M; Lyfenko, AD; Paolini, C; Canato, M; Riggiani, C; Dirksen, RT; and Protasi, F.

FASEB J. 2009; In Press.

Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+ calmodulin.

Fallon, JL; Baker, MR; Loy, RE; Xiong, L; Yang, G; Dirksen, RT; Hamilton, SL; Quiocho, FA.

Proc. Natl. Acad. Sci. 2009; In Press.

Reversal of RNA-dominant disease by antisense displacement of protein sequestered on repetitive RNA.

Wheeler, TM; Sobczak, K; Lueck, JD; Osborne, RJ; Lix, X; Dirksen, RT; Thornton, CA.

2009; In Revision.

Characterization and temporal development of cores in a mouse model of malignant hyperthermia.

Boncompagni, S.; Rossi, A.E.; Micaroni, M.; Hamilton, S.L.; Dirksen, R.T.; Franzini-Armstrong, C.; Protasi, F.

Proc Natl Acad Sci USA. 2009; 106(51): 21996-2001.

Sheu SS, Wang W, Cheng H, Dirksen RT

Future cardiology.. 2008 November 14 (6):551-554. Epub 1900 01 01.

Lyfenko AD, Dirksen RT

The Journal of physiology.. 2008 October 15586 (20):4815-24. Epub 09/04/2008.

Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP, Lakatta EG, Sheu SS, Ouyang K, Chen J, Dirksen RT, Cheng H

Cell.. 2008 July 25134 (2):279-90. Epub 1900 01 01.

RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knock-in mice.

Durham, WJ; Aracena-Parks, P; Long, C*; Rossi, AE; Goonasekera, SA; Boncompagni, S; Gilman, CP; Galvan, DL; Baker, M; Shirokova, N; Protasi, P; Dirksen, RT; and Hamilton, S.

Cell. 2008; 133: 1-13.

Superoxide flashes in single mitochondria.

Wang, W; Fang, W; Groom, L; Cheng, A; Zhang, W; Liu, J; Wang, X; Li, K; Han, P; Zhang, M; Yin, J; Wang, W; Mattson, MP; Kao, JPY; Lakatta, EG; Sheu, S-S; Ouyang, K; Chen, J; Dirksen, RT; and Cheng, H.

Cell. 2008; 134: 279-290.

Differential dependence of store-operated and excitation-coupled Ca2+ entry in skeletal muscle on Stim1 and Orai1.

Lyfenko, AD; and Dirksen, RT.

J. Physiol. 2008; .

Heat- and anesthetic-induced malignant hyperthermia in calsequestrin-1 knockout mice.

Marco, M; Quarta, M; Lyfenko, AD; Paolini, C; Canato, M; Dirksen, RT; Reggiani, C; and Protasi, F.

2008; Submitted.

Reversal of RNA-dominant disease by antisense displacement of protein sequestered on repetitive RNA.

Wheeler, TM; Sobczak, K; Lueck, JD; Osborne, RJ; Lin, X; Dirksen, RT; and Thornton, CA.

2008; Submitted.

Wheeler TM, Lueck JD, Swanson MS, Dirksen RT, Thornton CA

The Journal of clinical investigation.. 2007 December 117 (12):3952-7. Epub 1900 01 01.

Zvaritch E, Depreux F, Kraeva N, Loy RE, Goonasekera SA, Boncompagni S, Boncompagi S, Kraev A, Gramolini AO, Dirksen RT, Franzini-Armstrong C, Seidman CE, Seidman JG, Maclennan DH

Proceedings of the National Academy of Sciences of the United States of America.. 2007 November 20104 (47):18537-42. Epub 11/14/2007.

Smrcka AV, Oestreich EA, Blaxall BC, Dirksen RT

The Journal of physiology.. 2007 November 1584 (Pt 3):1029-31. Epub 09/20/2007.

Goonasekera SA, Beard NA, Groom L, Kimura T, Lyfenko AD, Rosenfeld A, Marty I, Dulhunty AF, Dirksen RT

The Journal of general physiology.. 2007 October 130 (4):365-78. Epub 09/10/2007.

Lueck JD, Lungu C, Mankodi A, Osborne RJ, Welle SL, Dirksen RT, Thornton CA

American journal of physiology. Cell physiology.. 2007 April 292 (4):C1291-7. Epub 11/29/2006.

Oestreich EA, Wang H, Malik S, Kaproth-Joslin KA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV

The Journal of biological chemistry.. 2007 February 23282 (8):5488-95. Epub 12/17/2006.

Kimura T, Pace SM, Wei L, Beard NA, Dirksen RT, Dulhunty AF

The Biochemical journal.. 2007 January 1401 (1):317-24. Epub 1900 01 01.

Lyfenko AD, Ducreux S, Wang Y, Xu L, Zorzato F, Ferreiro A, Meissner G, Treves S, Dirksen RT

Human mutation.. 2007 January 28 (1):61-8. Epub 1900 01 01.

Lueck JD, Mankodi A, Swanson MS, Thornton CA, Dirksen RT

The Journal of general physiology.. 2007 January 129 (1):79-94. Epub 12/11/2006.

Epac-mediated Activation of Phospholipase C? Plays a Critical Role in ?-adrenergic Receptor Dependent Enhancement of Ca2+ Mobilization in Cardiac Myocytes.

Oestreich, EA; Wang, H*; Malik, S; Kaproth-Joslin, KA; Blaxall, BC; Kelley, GG; Dirksen, RT; and Smrcka, AV.

J. Biol. Chem. 2007; 282: 5488-5495.

Two central core disease deletions in the C-terminal region of RyR1 alter muscle EC coupling by distinct mechanisms.

Lyfenko, AD; Ducreux, S; Wang, Y; Xu, L; Zorzato, F; Ferreiro, A; Meissner, G; Treves, S; and Dirksen, RT.

Hum. Mutat. 2007; 28: 61-68.

A Truncation in the RYR1 Gene Associated with Central Core Lesions in Skeletal Muscle Fibers.

Rossi, D; De Smet, P; Lyfenko, A; Galli, L; Lorenzini, S; Franci, D; Petrioli, F; Orrico, A; Tegazzin, V; Dirksen, RT; and Sorrentino, V.

J. Med. Genet. 2007; 44: e67.

Chloride channelopathy in myotonic dystrophy resulting from loss of post-transcriptional regulation for CLCN1.

Lueck, JD; Lungu, C; Mankodi, A; Osborne, RJ; Welle, SL; Dirksen, RT; and Thornton, CA.

Am. J. Physiol. 2007; 292: C1291-C1297.

Triadin binding to the C-terminal luminal loop of the ryanodine receptor is important for skeletal muscle excitation-contraction coupling.

Goonasekera, S; Beard, N; Groom, L; Kimura, T; Lyfenko, AF; Rosenfeld, A; Marty, I; Dulhunty, A; and Dirksen, RT.

J. Gen. Physiol. 2007; 130: 365-378.

Correction of ClC-1 splicing eliminates the chloride channelopathy and myotonia in myotonic dystrophy.

Wheeler, TM; Lueck, JD; Swanson, MS; Dirksen, RT; and Thornton, CA.

J. Clin. Invest. 2007; 117: 3952-3957.

A Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line.

Zvaritch, E; Depreux, F; Kraeva, N; Loy, RE; Goonasekera, SA; Boncompagi, S; Kraev, A; Gramolini, AO; Dirksen, RT; Franzini-Armstrong, C; Seidman, CE; Seidman, JG; and MacLennan, DH.

Proc. Natl. Acad. Sci. 2007; 104: 18537-18542.

Aracena-Parks P, Goonasekera SA, Gilman CP, Dirksen RT, Hidalgo C, Hamilton SL

The Journal of biological chemistry.. 2006 December 29281 (52):40354-68. Epub 10/27/2006.

Kannankeril PJ, Mitchell BM, Goonasekera SA, Chelu MG, Zhang W, Sood S, Kearney DL, Danila CI, De Biasi M, Wehrens XH, Pautler RG, Roden DM, Taffet GE, Dirksen RT, Anderson ME, Hamilton SL

Proceedings of the National Academy of Sciences of the United States of America.. 2006 August 8103 (32):12179-84. Epub 07/27/2006.

Rossi AE, Dirksen RT

Muscle & nerve.. 2006 June 33 (6):715-31. Epub 1900 01 01.

Chelu MG, Goonasekera SA, Durham WJ, Tang W, Lueck JD, Riehl J, Pessah IN, Zhang P, Bhattacharjee MB, Dirksen RT, Hamilton SL

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2006 February 20 (2):329-30. Epub 11/11/2005.

Malignant Hyperthermia Susceptibility

Rosenberg, H.; Dirksen, R.T.;.

GeneReviews. 2006; .

Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy

Kannankeril,P.J.; Mitchell,B.M.; Goonasekera,S.A.; Chelu,M.G.; Zhang,W.; Sood,S.; Kearney,D.L.; Danila,C.I.; De Biasi,M.; Wehrens,X.H.; Pautler,R.G.; Roden,D.M.; Taffet,G.E.; Dirksen,R.T.; Anderson,M.E.; Hamilton,S.L.;.

Proceedings National Academy Sciences United States of America. 2006; 103: 12179-12184.

Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in RyR1.

Aracena-Parks, P; Goonasekera, SA; Gilman, C; Dirksen, RT; Hidalgo, C; and Hamilton, SL.

J. Biol. Chem. 2006; 281: 40354-40368.

Wang H, Oestreich EA, Maekawa N, Bullard TA, Vikstrom KL, Dirksen RT, Kelley GG, Blaxall BC, Smrcka AV

Circulation research.. 2005 December 997 (12):1305-13. Epub 11/17/2005.

Goonasekera SA, Chen SR, Dirksen RT

American journal of physiology. Cell physiology.. 2005 December 289 (6):C1476-84. Epub 07/27/2005.

Beutner G, Sharma VK, Lin L, Ryu SY, Dirksen RT, Sheu SS

Biochimica et biophysica acta.. 2005 November 101717 (1):1-10. Epub 10/11/2005.

Kimura T, Nakamori M, Lueck JD, Pouliquin P, Aoike F, Fujimura H, Dirksen RT, Takahashi MP, Dulhunty AF, Sakoda S

Human molecular genetics.. 2005 August 114 (15):2189-200. Epub 06/22/2005.

Avila G, Dirksen RT

Cell calcium.. 2005 July 38 (1):35-44. Epub 1900 01 01.

Dirksen RT, Avila G

Biophysical journal.. 2004 November 87 (5):3193-204. Epub 09/03/2004.

Lyfenko AD, Goonasekera SA, Dirksen RT

Biochemical and biophysical research communications.. 2004 October 1322 (4):1256-66. Epub 1900 01 01.

Weiss RG, O'Connell KM, Flucher BE, Allen PD, Grabner M, Dirksen RT

American journal of physiology. Cell physiology.. 2004 October 287 (4):C1094-102. Epub 06/16/2004.

Du GG, Avila G, Sharma P, Khanna VK, Dirksen RT, MacLennan DH

The Journal of biological chemistry.. 2004 September 3279 (36):37566-74. Epub 06/28/2004.

He X, Liu Y, Sharma V, Dirksen RT, Waugh R, Sheu SS, Min W

The American journal of pathology.. 2003 July 163 (1):243-51. Epub 1900 01 01.

Avila G, Lee EH, Perez CF, Allen PD, Dirksen RT

The Journal of biological chemistry.. 2003 June 20278 (25):22600-8. Epub 04/17/2003.

Leuranguer V, Dirksen RT, Beam KG

The Journal of general physiology.. 2003 June 121 (6):541-50. Epub 05/12/2003.

Avila G, O'Connell KM, Dirksen RT

The Journal of general physiology.. 2003 April 121 (4):277-86. Epub 03/17/2003.

Papineni RV, O'Connell KM, Zhang H, Dirksen RT, Hamilton SL

The Journal of biological chemistry.. 2002 December 20277 (51):49167-74. Epub 10/02/2002.

O'Connell KM, Yamaguchi N, Meissner G, Dirksen RT

The Journal of general physiology.. 2002 September 120 (3):337-47. Epub 1900 01 01.

Dirksen RT, Avila G

Trends in cardiovascular medicine.. 2002 July 12 (5):189-97. Epub 1900 01 01.

Dirksen RT

Frontiers in bioscience : a journal and virtual library.. 2002 March 17 :d659-70. Epub 03/01/2002.

Alano CC, Beutner G, Dirksen RT, Gross RA, Sheu SS

Journal of neurochemistry.. 2002 February 80 (3):531-8. Epub 1900 01 01.

Bi-directional coupling between dihydropyridine receptors and ryanodine receptors

Dirksen,R.T.;.

Frontiers Bioscience. 2002; 7:d659-70.: d659-d670.

Dirksen RT

Neurobiology of aging.. 2002 23 (5):837-9; discussion 841-2. Epub 1900 01 01.

Avila G, Dirksen RT

The Journal of general physiology.. 2001 September 118 (3):277-90. Epub 1900 01 01.

Avila G, O'Connell KM, Groom LA, Dirksen RT

The Journal of biological chemistry.. 2001 May 25276 (21):17732-8. Epub 01/22/2001.

Avila G, O'Brien JJ, Dirksen RT

Proceedings of the National Academy of Sciences of the United States of America.. 2001 March 2798 (7):4215-20. Epub 1900 01 01.

Excitation--contraction uncoupling by a human central core disease mutation in the ryanodine receptor

Avila,G.; O'Brien,J.J.; Dirksen,R.T.;.

Proceedings National Academy Sciences United States of America. 2001; 98(7): 4215-4220.

O'Connell KM, Dirksen RT

The Journal of physiology.. 2000 December 15529 Pt 3 (Pt 3):647-59. Epub 1900 01 01.

Avila G, Dirksen RT

The Journal of general physiology.. 2000 April 115 (4):467-80. Epub 1900 01 01.

Suda N, Dirksen RT, Gonzalez A, Beam KG

Pflu?gers Archiv : European journal of physiology.. 2000 March 439 (5):555-8. Epub 1900 01 01.

Prolonged depolarization promotes fast gating kinetics of L-type Ca2+ channels in mouse skeletal myotubes

O'Connell,K.M.; Dirksen,R.T.;.

Journal Physiology. 2000; 529: 647-659.

Dirksen RT, Beam KG

The Journal of general physiology.. 1999 September 114 (3):393-403. Epub 1900 01 01.

Grabner M, Dirksen RT, Suda N, Beam KG

The Journal of biological chemistry.. 1999 July 30274 (31):21913-9. Epub 1900 01 01.

Grabner M, Dirksen RT, Beam KG

Proceedings of the National Academy of Sciences of the United States of America.. 1998 February 1795 (4):1903-8. Epub 1900 01 01.

Dirksen RT, Nakai J, Gonzalez A, Imoto K, Beam KG

Biophysical journal.. 1997 September 73 (3):1402-9. Epub 1900 01 01.

Dirksen RT, Beam KG

The Journal of general physiology.. 1996 June 107 (6):731-42. Epub 1900 01 01.

Nakai J, Dirksen RT, Nguyen HT, Pessah IN, Beam KG, Allen PD

Nature.. 1996 March 7380 (6569):72-5. Epub 1900 01 01.

Dirksen RT, Beam KG

The Journal of general physiology.. 1995 February 105 (2):227-47. Epub 1900 01 01.

Arreola J, Dirksen RT, Perez-Cornejo P, Piech KM, Sheu SS

European journal of pharmacology.. 1994 December 27271 (2-3):309-17. Epub 1900 01 01.

Mori Y, Niidome T, Fujita Y, Mynlieff M, Dirksen RT, Beam KG, Iwabe N, Miyata T, Furutama D, Furuichi T

Annals of the New York Academy of Sciences.. 1993 December 20707 :87-108. Epub 1900 01 01.

Fujita Y, Mynlieff M, Dirksen RT, Kim MS, Niidome T, Nakai J, Friedrich T, Iwabe N, Miyata T, Furuichi T

Neuron.. 1993 April 10 (4):585-98. Epub 1900 01 01.

Arreola J, Dirksen RT, Shieh RC, Williford DJ, Sheu SS

The American journal of physiology.. 1991 August 261 (2 Pt 1):C393-7. Epub 1900 01 01.

Sheu SS, Sharma VK, Korth M, Moscucci A, Dirksen RT, Jou MJ

Annals of the New York Academy of Sciences.. 1991 639 :398-407. Epub 1900 01 01.

Enyeart JJ, Dirksen RT, Sharma VK, Williford DJ, Sheu SS

Molecular pharmacology.. 1990 May 37 (5):752-7. Epub 1900 01 01.

Dirksen RT, Sheu SS

The American journal of physiology.. 1990 March 258 (3 Pt 2):H907-11. Epub 1900 01 01.

Reichman M, Dirksen R, Abood LG, Gala D

Biochemical pharmacology.. 1986 November 1535 (22):3995-8. Epub 1900 01 01.

Books

Medical Genetics Information Resource [database online] (2006)

Chapter: Malignant hyperthermia Susceptibility is: GeneReviews at GeneTests.

Authors: Rosenberg, H; and Dirksen, RT

Publisher: University of Washington, Seattle 2006

Ryanodine Receptors: Structure, Function and Dysfunction in Clinical Disease (2005)

Chapter: Pathophysiology of muscle disorders linked to mutations in the skeletal muscle ryanodine receptor.

Authors: Dirksen RT and Avila G

Publisher: Springer 2005