Â鶹ÊÓƵ

Skip to content
Home
David I. Yule, Ph.D.

David I. Yule, Ph.D.

Looking for more Information?

Visit my lab website to learn more about my research, collaborators, latest news, etc.

About Me

Faculty Appointments

Professor - Department of Pharmacology and Physiology (SMD)

Louis C. Lasagna Professorship in Experimental Therapeutics - Department of Pharmacology and Physiology (SMD)

Professor - Department of Medicine, Gastroenterology/Hepatology (SMD) - Joint

Credentials

Post-doctoral Training & Residency

M.R.C. Secretory Control Group, Physiology Department, University of Liverpool. Supervisor: Prof. O.H. Petersen.

Department of Physiology, University of Michigan. Supervisor: Prof. J.A. Williams. 1990 - 1992

Education

PhD | UK-Univ of Liverpool. Physiology. 1989

BS | UK-Portsmouth Polytechnic. Pharmacology. 1985

Research

In exocrine acinar cells regulation of intracellular calcium plays a pivotal role in controlling fluid and protein secretion. Exposure of cells to neurotransmitters and hormones results in a rapid elevation of intracellular calcium. This increase in [Ca2+]i carries complex spatial and temporal infor...
In exocrine acinar cells regulation of intracellular calcium plays a pivotal role in controlling fluid and protein secretion. Exposure of cells to neurotransmitters and hormones results in a rapid elevation of intracellular calcium. This increase in [Ca2+]i carries complex spatial and temporal information important to the physiology of the acinar cell. Research in this laboratory focuses on gaining a better understanding of the mechanisms which underlie these signaling patterns with a primary goal of relating this knowledge to the physiology and pathophysiology of exocrine cells.
Although all Ca2+ mobilizing agonists in pancreatic acinar cells utilize the phosphoinositide-signaling (PI) pathway, stimulation by individual agents results in markedly different temporal and spatial patterns of Ca2+ signaling. One project is designed to understand at the molecular level how the cell effectively "knows" which PI-coupled agonist it is currently exposed to. Given that tremendous molecular diversity is expressed at all levels of this signaling pathway, our working hypothesis is that individual agonists do not couple to the signaling machinery in an identical fashion. This study involves precisely defining by molecular techniques the individual signaling proteins expressed in the acinar cell and then subsequently assessing if individual agonists utilize discrete and different elements of the PI-signaling pathway. We are utilizing fluorescence imaging techniques including high-speed confocal microscopy to monitor [Ca2+]i while manipulating the signaling pathway with neutralizing antibodies and antisense technology.

A further project relates to the organization and regulation of calcium release sites in exocrine cells. These organelles are defined by the expression of receptors for the second messenger Inositol 1,4,5-trisphosphate. In acinar cells the distribution of these receptors is tightly localized to an area associated with the actin cytoskeleton in the apical secretory pole of the cell. This distribution of receptors is the major factor in defining the spatial characteristics of the Ca2+ signal. The nature of the association with the cytoskeleton is being investigated. In addition the regulation of these receptors by phosphorylation and the consequences this may have for Ca2+ signaling are also being studied.

Publications

Journal Articles

Rosa N, Ivanova H, Wagner LE, Kale J, La Rovere R, Welkenhuyzen K, Louros N, Karamanou S, Shabardina V, Lemmens I, Vandermarliere E, Hamada K, Ando H, Rousseau F, Schymkowitz J, Tavernier J, Mikoshiba K, Economou A, Andrews DW, Parys JB, Yule DI, Bultynck G

Cell death and differentiation.. 2022 April 29 (4):788-805. Epub 11/08/2021.

Arige V, Yule DI

Cell calcium.. 2020 September 90 :102243. Epub 06/10/2020.

Wahl AM, Yule DI

Cell calcium.. 2020 September 90 :102250. Epub 07/08/2020.

Leonard A, Su PY, Yule DI, Rahman A, Fazal F

Shock.. 2020 August 54 (2):245-255. Epub 1900 01 01.

Hou H, Wang L, Fu T, Papasergi M, Yule DI, Xia H

Molecular neurobiology.. 2020 June 57 (6):2539-2550. Epub 03/25/2020.

Yoast RE, Emrich SM, Zhang X, Xin P, Johnson MT, Fike AJ, Walter V, Hempel N, Yule DI, Sneyd J, Gill DL, Trebak M

Nature communications.. 2020 May 1511 (1):2444. Epub 05/15/2020.

Ivanova H, Vervliet T, Monaco G, Terry LE, Rosa N, Baker MR, Parys JB, Serysheva II, Yule DI, Bultynck G

Cold Spring Harbor perspectives in biology.. 2020 April 112 (4)Epub 04/01/2020.

Vera-Sigüenza E, Pages N, Rugis J, Yule DI, Sneyd J

Bulletin of mathematical biology.. 2020 March 1182 (3):38. Epub 03/11/2020.

Aulestia FJ, Groeling J, Bomfim GHS, Costiniti V, Manikandan V, Chaloemtoem A, Concepcion AR, Li Y, Wagner LE, Idaghdour Y, Yule DI, Lacruz RS

Science signaling.. 2020 February 1813 (619)Epub 02/18/2020.

Schulman JJ, Szczesniak LM, Bunker EN, Nelson HA, Roe MW, Wagner LE, Yule DI, Wojcikiewicz RJH

Cell death and differentiation.. 2019 December 26 (12):2682-2694. Epub 04/11/2019.

Ivanova H, Wagner LE, Tanimura A, Vandermarliere E, Luyten T, Welkenhuyzen K, Alzayady KJ, Wang L, Hamada K, Mikoshiba K, De Smedt H, Martens L, Yule DI, Parys JB, Bultynck G

Cellular and molecular life sciences : CMLS.. 2019 October 76 (19):3843-3859. Epub 04/16/2019.

Bartok A, Weaver D, Golenár T, Nichtova Z, Katona M, Bánsághi S, Alzayady KJ, Thomas VK, Ando H, Mikoshiba K, Joseph SK, Yule DI, Csordás G, Hajnóczky G

Nature communications.. 2019 August 1910 (1):3726. Epub 08/19/2019.

Pages N, Vera-Sigüenza E, Rugis J, Kirk V, Yule DI, Sneyd J

Bulletin of mathematical biology.. 2019 May 81 (5):1394-1426. Epub 01/14/2019.

Bennett JA, Ture SK, Schmidt RA, Mastrangelo MA, Cameron SJ, Terry LE, Yule DI, Morrell CN, Lowenstein CJ

The Journal of pharmacology and experimental therapeutics.. 2019 May 369 (2):182-187. Epub 02/14/2019.

Yule DI, Nánási PP, Magyar ZÉ, Márton I, Skaliczki M, Diszházi G, Almássy J

The ocular surface.. 2019 April 17 (2):272-277. Epub 01/24/2019.

Vera-Sigüenza E, Pages N, Rugis J, Yule DI, Sneyd J

Bulletin of mathematical biology.. 2019 March 81 (3):699-721. Epub 11/27/2018.

Leonard A, Grose V, Paton AW, Paton JC, Yule DI, Rahman A, Fazal F

Scientific reports.. 2019 February 149 (1):2096. Epub 02/14/2019.

Lock JT, Alzayady KJ, Yule DI, Parker I

Science signaling.. 2018 December 1811 (561)Epub 12/18/2018.

Joseph SK, Young M, Alzayady K, Yule DI, Ali M, Booth DM, Hajnóczky G

The Journal of biological chemistry.. 2018 November 9293 (45):17464-17476. Epub 09/18/2018.

Wang L, Yule DI

Biochimica et biophysica acta. Molecular cell research.. 2018 November 1865 (11 Pt B):1698-1706. Epub 07/17/2018.

Vervliet T, Yule DI, Bultynck G

Trends in biochemical sciences.. 2018 October 43 (10):741-744. Epub 08/28/2018.

de Rubio RG, Ransom RF, Malik S, Yule DI, Anantharam A, Smrcka AV

Science signaling.. 2018 September 1111 (547)Epub 09/11/2018.

Wang L, Wagner LE, Alzayady KJ, Yule DI

The Journal of biological chemistry.. 2018 August 24293 (34):13112-13124. Epub 07/03/2018.

Terry LE, Alzayady KJ, Furati E, Yule DI

Messenger.. 2018 June 6 (1-2):29-44. Epub 1900 01 01.

Almássy J, Siguenza E, Skaliczki M, Matesz K, Sneyd J, Yule DI, Nánási PP

Pflu?gers Archiv : European journal of physiology.. 2018 April 470 (4):613-621. Epub 01/17/2018.

Williams JA, Yule DI

Annals of translational medicine.. 2018 April 6 (7):124. Epub 1900 01 01.

Nurbaeva MK, Eckstein M, Devotta A, Saint-Jeannet JP, Yule DI, Hubbard MJ, Lacruz RS

Frontiers in physiology.. 2018 9 :801. Epub 07/02/2018.

Wang L, Wagner LE, Alzayady KJ, Yule DI

The Journal of biological chemistry.. 2017 July 14292 (28):11714-11726. Epub 05/19/2017.

Luyten T, Welkenhuyzen K, Roest G, Kania E, Wang L, Bittremieux M, Yule DI, Parys JB, Bultynck G

Biochimica et biophysica acta. Molecular cell research.. 2017 June 1864 (6):947-956. Epub 02/28/2017.

Sneyd J, Means S, Zhu D, Rugis J, Won JH, Yule DI

Journal of theoretical biology.. 2017 April 21419 :383-393. Epub 05/04/2016.

Bittremieux M, Gerasimenko JV, Schuermans M, Luyten T, Stapleton E, Alzayady KJ, De Smedt H, Yule DI, Mikoshiba K, Vangheluwe P, Gerasimenko OV, Parys JB, Bultynck G

Cell calcium.. 2017 March 62 :60-70. Epub 02/01/2017.

Sneyd J, Han JM, Wang L, Chen J, Yang X, Tanimura A, Sanderson MJ, Kirk V, Yule DI

Proceedings of the National Academy of Sciences of the United States of America.. 2017 February 14114 (7):1456-1461. Epub 02/01/2017.

Concepcion AR, Vaeth M, Wagner LE, Eckstein M, Hecht L, Yang J, Crottes D, Seidl M, Shin HP, Weidinger C, Cameron S, Turvey SE, Issekutz T, Meyts I, Lacruz RS, Cuk M, Yule DI, Feske S

The Journal of clinical investigation.. 2016 November 1126 (11):4303-4318. Epub 10/10/2016.

Ivanova H, Ritane A, Wagner L, Luyten T, Shapovalov G, Welkenhuyzen K, Seitaj B, Monaco G, De Smedt H, Prevarskaya N, Yule DI, Parys JB, Bultynck G

Oncotarget.. 2016 August 237 (34):55704-55720. Epub 1900 01 01.

Wang L, Alzayady KJ, Yule DI

The Journal of physiology.. 2016 June 1594 (11):2867-76. Epub 12/07/2015.

Gerber S, Alzayady KJ, Burglen L, Brémond-Gignac D, Marchesin V, Roche O, Rio M, Funalot B, Calmon R, Durr A, Gil-da-Silva-Lopes VL, Ribeiro Bittar MF, Orssaud C, Héron B, Ayoub E, Berquin P, Bahi-Buisson N, Bole C, Masson C, Munnich A, Simons M, Delous M, Dollfus H, Boddaert N, Lyonnet S, Kaplan J, Calvas P, Yule DI, Rozet JM, Fares Taie L

American journal of human genetics.. 2016 May 598 (5):971-980. Epub 04/21/2016.

Alzayady KJ, Wang L, Chandrasekhar R, Wagner LE, Van Petegem F, Yule DI

Science signaling.. 2016 April 59 (422):ra35. Epub 04/05/2016.

Chandrasekhar R, Alzayady KJ, Wagner LE, Yule DI

The Journal of biological chemistry.. 2016 March 4291 (10):4846-60. Epub 01/11/2016.

Teos LY, Zhang Y, Cotrim AP, Swaim W, Won JH, Ambrus J, Shen L, Bebris L, Grisius M, Jang SI, Yule DI, Ambudkar IS, Alevizos I

Scientific reports.. 2015 September 145 :13953. Epub 09/14/2015.

Vervloessem T, Yule DI, Bultynck G, Parys JB

Biochimica et biophysica acta.. 2015 September 1853 (9):1992-2005. Epub 12/10/2014.

Alzayady KJ, Sebé-Pedrós A, Chandrasekhar R, Wang L, Ruiz-Trillo I, Yule DI

Molecular biology and evolution.. 2015 September 32 (9):2236-53. Epub 04/23/2015.

Chandrasekhar R, Alzayady KJ, Yule DI

Biochemical Society transactions.. 2015 June 43 (3):364-70. Epub 1900 01 01.

Hedgepeth SC, Garcia MI, Wagner LE, Rodriguez AM, Chintapalli SV, Snyder RR, Hankins GD, Henderson BR, Brodie KM, Yule DI, van Rossum DB, Boehning D

The Journal of biological chemistry.. 2015 March 13290 (11):7304-13. Epub 02/02/2015.

Wagner LE, Groom LA, Dirksen RT, Yule DI

Cell calcium.. 2014 August 56 (2):96-107. Epub 06/06/2014.

Yule DI

Cell calcium.. 2014 June 55 (6):281. Epub 04/18/2014.

Bánsághi S, Golenár T, Madesh M, Csordás G, RamachandraRao S, Sharma K, Yule DI, Joseph SK, Hajnóczky G

The Journal of biological chemistry.. 2014 March 21289 (12):8170-81. Epub 01/27/2014.

Kemény LV, Schnúr A, Czepán M, Rakonczay Z, Gál E, Lonovics J, Lázár G, Simonka Z, Venglovecz V, Maléth J, Judák L, Németh IB, Szabó K, Almássy J, Virág L, Geisz A, Tiszlavicz L, Yule DI, Wittmann T, Varró A, Hegyi P

American journal of physiology. Gastrointestinal and liver physiology.. 2013 October 15305 (8):G552-63. Epub 08/01/2013.

Alzayady KJ, Wagner LE, Chandrasekhar R, Monteagudo A, Godiska R, Tall GG, Joseph SK, Yule DI

The Journal of biological chemistry.. 2013 October 11288 (41):29772-84. Epub 08/16/2013.

Alzayady KJ, Chandrasekhar R, Yule DI

The Journal of biological chemistry.. 2013 April 19288 (16):11122-34. Epub 03/11/2013.

Wei-Lapierre L, Gong G, Gerstner BJ, Ducreux S, Yule DI, Pouvreau S, Wang X, Sheu SS, Cheng H, Dirksen RT, Wang W

The Journal of biological chemistry.. 2013 April 12288 (15):10567-77. Epub 03/01/2013.

Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, Smrcka AV

Cell.. 2013 March 28153 (1):216-27. Epub 1900 01 01.

Almassy J, Yule DI

Cold Spring Harbor protocols.. 2013 January 12013 (1)Epub 01/01/2013.

Almassy J, Yule DI

Cold Spring Harbor protocols.. 2013 January 12013 (1)Epub 01/01/2013.

Almassy J, Yule DI

Cold Spring Harbor protocols.. 2013 January 12013 (1)Epub 01/01/2013.

Almassy J, Yule DI

Cold Spring Harbor protocols.. 2013 January 12013 (1)Epub 01/01/2013.

Gunter TE, Gerstner B, Gunter KK, Malecki J, Gelein R, Valentine WM, Aschner M, Yule DI

Neurotoxicology.. 2013 January 34 :118-27. Epub 11/09/2012.

Monaco G, Decrock E, Nuyts K, Wagner LE, Luyten T, Strelkov SV, Missiaen L, De Borggraeve WM, Leybaert L, Yule DI, De Smedt H, Parys JB, Bultynck G

PloS one.. 2013 8 (8):e73386. Epub 08/30/2013.

Patterson K, Catalán MA, Melvin JE, Yule DI, Crampin EJ, Sneyd J

American journal of physiology. Gastrointestinal and liver physiology.. 2012 November 15303 (10):G1153-63. Epub 08/16/2012.

Palk L, Sneyd J, Patterson K, Shuttleworth TJ, Yule DI, Maclaren O, Crampin EJ

Journal of theoretical biology.. 2012 July 21305 :45-53. Epub 04/14/2012.

Wagner LE, Yule DI

The Journal of physiology.. 2012 July 15590 (14):3245-59. Epub 04/30/2012.

Bhattacharya S, Verrill DS, Carbone KM, Brown S, Yule DI, Giovannucci DR

The Journal of physiology.. 2012 June 1590 (11):2721-37. Epub 03/25/2012.

Almassy J, Won JH, Begenisich TB, Yule DI

The Journal of general physiology.. 2012 February 139 (2):121-33. Epub 1900 01 01.

Park HS, Betzenhauser MJ, Zhang Y, Yule DI

American journal of physiology. Gastrointestinal and liver physiology.. 2012 January 1302 (1):G97-G104. Epub 09/29/2011.

Won JH, Zhang Y, Ji B, Logsdon CD, Yule DI

Molecular biology of the cell.. 2011 February 122 (3):421-36. Epub 1900 01 01.

Masuda W, Betzenhauser MJ, Yule DI

The Journal of biological chemistry.. 2010 November 26285 (48):37927-38. Epub 09/27/2010.

Yule DI

The international journal of biochemistry & cell biology.. 2010 November 42 (11):1757-61. Epub 07/15/2010.

Palk L, Sneyd J, Shuttleworth TJ, Yule DI, Crampin EJ

Journal of theoretical biology.. 2010 October 21266 (4):625-40. Epub 06/25/2010.

Yule DI, Betzenhauser MJ, Joseph SK

Cell calcium.. 2010 June 47 (6):469-79. Epub 05/26/2010.

Park KM, Yule DI, Bowers WJ

Cellular signalling.. 2010 March 22 (3):519-26. Epub 1900 01 01.

Brown DA, Yule DI

Biochimica et biophysica acta.. 2010 February 1803 (2):275-87. Epub 12/21/2009.

Ryu SY, Peixoto PM, Won JH, Yule DI, Kinnally KW

Cell calcium.. 2010 January 47 (1):65-76. Epub 01/06/2010.

Betzenhauser MJ, Yule DI

Current topics in membranes.. 2010 66 :273-98. Epub 07/25/2010.

Park KM, Yule DI, Bowers WJ

The Journal of biological chemistry.. 2009 October 2284 (40):27557-66. Epub 08/07/2009.

Betzenhauser MJ, Fike JL, Wagner LE, Yule DI

The Journal of biological chemistry.. 2009 September 11284 (37):25116-25. Epub 07/16/2009.

Gin E, Wagner LE, Yule DI, Sneyd J

Chaos.. 2009 September 19 (3):037104. Epub 1900 01 01.

Betzenhauser MJ, Wagner LE, Park HS, Yule DI

The Journal of biological chemistry.. 2009 June 12284 (24):16156-16163. Epub 04/22/2009.

Gin E, Falcke M, Wagner LE, Yule DI, Sneyd J

Biophysical journal.. 2009 May 2096 (10):4053-62. Epub 1900 01 01.

Gin E, Falcke M, Wagner LE, Yule DI, Sneyd J

Journal of theoretical biology.. 2009 April 7257 (3):460-74. Epub 12/30/2008.

Park KM, Yule DI, Bowers WJ

The Journal of biological chemistry.. 2008 November 28283 (48):33069-79. Epub 10/06/2008.

Betzenhauser MJ, Wagner LE, Won JH, Yule DI

Methods : a companion to Methods in enzymology.. 2008 November 46 (3):177-82. Epub 10/16/2008.

Park HS, Betzenhauser MJ, Won JH, Chen J, Yule DI

The Journal of biological chemistry.. 2008 September 19283 (38):26081-8. Epub 07/24/2008.

Warner JD, Peters CG, Saunders R, Won JH, Betzenhauser MJ, Gunning WT, Yule DI, Giovannucci DR

American journal of physiology. Gastrointestinal and liver physiology.. 2008 September 295 (3):G629-40. Epub 07/31/2008.

Betzenhauser MJ, Wagner LE, Iwai M, Michikawa T, Mikoshiba K, Yule DI

The Journal of biological chemistry.. 2008 August 1283 (31):21579-87. Epub 05/27/2008.

Wagner LE, Joseph SK, Yule DI

The Journal of physiology.. 2008 August 1586 (15):3577-96. Epub 06/05/2008.

Schug ZT, da Fonseca PC, Bhanumathy CD, Wagner L, Zhang X, Bailey B, Morris EP, Yule DI, Joseph SK

The Journal of biological chemistry.. 2008 February 1283 (5):2939-48. Epub 11/19/2007.

Won JH, Cottrell WJ, Foster TH, Yule DI

American journal of physiology. Gastrointestinal and liver physiology.. 2007 December 293 (6):G1166-77. Epub 09/27/2007.

Gin E, Crampin EJ, Brown DA, Shuttleworth TJ, Yule DI, Sneyd J

Journal of theoretical biology.. 2007 September 7248 (1):64-80. Epub 05/03/2007.

Brown DA, Yule DI

Biochimica et biophysica acta.. 2007 February 1773 (2):166-75. Epub 09/19/2006.

Won JH, Yule DI

American journal of physiology. Gastrointestinal and liver physiology.. 2006 July 291 (1):G146-55. Epub 02/16/2006.

Wagner LE, Betzenhauser MJ, Yule DI

The Journal of biological chemistry.. 2006 June 23281 (25):17410-17419. Epub 04/18/2006.

Khan MT, Wagner L, Yule DI, Bhanumathy C, Joseph SK

The Journal of biological chemistry.. 2006 February 10281 (6):3731-7. Epub 12/06/2005.

Sneyd J, Tsaneva-Atanasova K, Reznikov V, Bai Y, Sanderson MJ, Yule DI

Proceedings of the National Academy of Sciences of the United States of America.. 2006 February 7103 (6):1675-80. Epub 01/30/2006.

Chen Y, Warner JD, Yule DI, Giovannucci DR

American journal of physiology. Cell physiology.. 2005 November 289 (5):C1209-19. Epub 07/06/2005.

Mignen O, Thompson JL, Yule DI, Shuttleworth TJ

The Journal of physiology.. 2005 May 1564 (Pt 3):791-801. Epub 03/10/2005.

Tsaneva-Atanasova K, Yule DI, Sneyd J

Biophysical journal.. 2005 March 88 (3):1535-51. Epub 12/13/2004.

Wagner LE, Li WH, Joseph SK, Yule DI

The Journal of biological chemistry.. 2004 October 29279 (44):46242-52. Epub 08/11/2004.

Brown DA, Bruce JI, Straub SV, Yule DI

The Journal of biological chemistry.. 2004 September 17279 (38):39485-94. Epub 07/19/2004.

Gunter TE, Yule DI, Gunter KK, Eliseev RA, Salter JD

FEBS letters.. 2004 June 1567 (1):96-102. Epub 1900 01 01.

Bruce JI, Giovannucci DR, Blinder G, Shuttleworth TJ, Yule DI

The Journal of biological chemistry.. 2004 March 26279 (13):12909-17. Epub 12/29/2003.

Yule DI, Sneyd J, Thompson JL, Tsaneva-Atanasova K, Shuttleworth TJ, Yule DI, Thompson JL, Shuttleworth TJ

Proceedings of the National Academy of Sciences of the United States of America.. 2004 February 3101 (5):1392-6. Epub 01/20/2004.

Straub SV, Wagner LE, Bruce JI, Yule DI

Biological research.. 2004 37 (4):593-602. Epub 1900 01 01.

Bruce JI, Straub SV, Yule DI

Cell calcium.. 2003 December 34 (6):431-44. Epub 1900 01 01.

Wagner LE, Li WH, Yule DI

The Journal of biological chemistry.. 2003 November 14278 (46):45811-7. Epub 08/25/2003.

Brown DA, Melvin JE, Yule DI

American journal of physiology. Gastrointestinal and liver physiology.. 2003 November 285 (5):G804-12. Epub 07/03/2003.

Yule DI, Straub SV, Bruce JI

Biochemical Society transactions.. 2003 October 31 (Pt 5):954-7. Epub 1900 01 01.

Sneyd J, Tsaneva-Atanasova K, Bruce JI, Straub SV, Giovannucci DR, Yule DI

Biophysical journal.. 2003 September 85 (3):1392-405. Epub 1900 01 01.

Bruce JI, Yule DI, Shuttleworth TJ

The Journal of biological chemistry.. 2002 December 13277 (50):48172-81. Epub 10/03/2002.

Straub SV, Giovannucci DR, Bruce JI, Yule DI

The Journal of biological chemistry.. 2002 August 30277 (35):31949-56. Epub 06/13/2002.

Giovannucci DR, Bruce JI, Straub SV, Arreola J, Sneyd J, Shuttleworth TJ, Yule DI

The Journal of physiology.. 2002 April 15540 (Pt 2):469-84. Epub 1900 01 01.

Bruce JI, Shuttleworth TJ, Giovannucci DR, Yule DI

The Journal of biological chemistry.. 2002 January 11277 (2):1340-8. Epub 11/01/2001.

Beutner G, Sharma VK, Giovannucci DR, Yule DI, Sheu SS

The Journal of biological chemistry.. 2001 June 15276 (24):21482-8. Epub 04/10/2001.

Yule DI

The Journal of general physiology.. 2001 May 117 (5):431-4. Epub 1900 01 01.

Giovannucci DR, Groblewski GE, Sneyd J, Yule DI

The Journal of biological chemistry.. 2000 October 27275 (43):33704-11. Epub 1900 01 01.

Straub SV, Giovannucci DR, Yule DI

The Journal of general physiology.. 2000 October 116 (4):547-60. Epub 1900 01 01.

Giovannucci DR, Sneyd J, Groblewski GE, Yule DI

Journal of Korean medical science.. 2000 August 15 Suppl (Suppl):S55-6. Epub 1900 01 01.

LeBeau AP, Yule DI, Groblewski GE, Sneyd J

The Journal of general physiology.. 1999 June 113 (6):851-72. Epub 1900 01 01.

Wojcikiewicz RJ, Ernst SA, Yule DI

Gastroenterology.. 1999 May 116 (5):1194-201. Epub 1900 01 01.

Yule DI, Baker CW, Williams JA

The American journal of physiology.. 1999 January 276 (1):G271-9. Epub 1900 01 01.

Giovannucci DR, Yule DI, Stuenkel EL

American journal of physiology. Cell physiology.. 1998 September 1275 (3):C732-C739. Epub 1900 01 01.

Giovannucci DR, Yule DI, Stuenkel EL

The American journal of physiology.. 1998 September 275 (3):C732-9. Epub 1900 01 01.

Ohnishi H, Samuelson LC, Yule DI, Ernst SA, Williams JA

The Journal of clinical investigation.. 1997 December 15100 (12):3044-52. Epub 1900 01 01.

Ohnishi H, Ernst SA, Yule DI, Baker CW, Williams JA

The Journal of biological chemistry.. 1997 June 20272 (25):16056-61. Epub 1900 01 01.

Zhang W, Sarosi G, Barnhart D, Yule DI, Mulholland MW

The American journal of physiology.. 1997 May 272 (5 Pt 1):G1175-85. Epub 1900 01 01.

Yule DI, Ernst SA, Ohnishi H, Wojcikiewicz RJ

The Journal of biological chemistry.. 1997 April 4272 (14):9093-8. Epub 1900 01 01.

Westfall MV, Pasyk KA, Yule DI, Samuelson LC, Metzger JM

Cell motility and the cytoskeleton.. 1997 36 (1):43-54. Epub 1900 01 01.

Williams JA, Groblewski GE, Ohnishi H, Yule DI

Digestion.. 1997 58 Suppl 1 :42-5. Epub 1900 01 01.

Yule DI, Stuenkel E, Williams JA

The American journal of physiology.. 1996 October 271 (4 Pt 1):C1285-94. Epub 1900 01 01.

Palmer RK, Yule DI, McEwen EL, Williams JA, Fisher SK

Journal of lipid mediators and cell signalling. 1996 September 14 (1-3):169-74. Epub 1900 01 01.

Palmer RK, Yule DI, Shewach DS, Williams JA, Fisher SK

The American journal of physiology.. 1996 July 271 (1 Pt 1):C43-53. Epub 1900 01 01.

Kimball BC, Yule DI, Mulholland MW

The American journal of physiology.. 1996 April 270 (4 Pt 1):G587-93. Epub 1900 01 01.

Kimball BC, Yule DI, Mulholland MW

The American journal of physiology.. 1996 April 270 (4 Pt 1):G594-603. Epub 1900 01 01.

Deutsch DE, Williams JA, Yule DI

The American journal of physiology.. 1995 November 269 (5 Pt 1):G779-88. Epub 1900 01 01.

Yang J, Williams JA, Yule DI, Logsdon CD

Molecular pharmacology.. 1995 September 48 (3):477-85. Epub 1900 01 01.

Massa E, Kelly KM, Yule DI, MacDonald RL, Uhler MD

Molecular pharmacology.. 1995 April 47 (4):707-16. Epub 1900 01 01.

Simeone DM, Yule DI, Logsdon CD, Williams JA

Regulatory peptides.. 1995 January 2655 (2):197-206. Epub 1900 01 01.

Palmer RK, Yule DI, McEwen EL, Williams JA, Fisher SK

Journal of neurochemistry.. 1994 December 63 (6):2099-107. Epub 1900 01 01.

Bode HP, Yule DI, Fehmann HC, Göke B, Williams JA

Biochemical and biophysical research communications.. 1994 November 30205 (1):435-40. Epub 1900 01 01.

Yule DI, Kim ET, Williams JA

Biochemical and biophysical research communications.. 1994 August 15202 (3):1697-704. Epub 1900 01 01.

Blevins GT, van de Westerlo EM, Yule DI, Williams JA

The Journal of pharmacology and experimental therapeutics.. 1994 June 269 (3):911-6. Epub 1900 01 01.

Duan RD, Wagner AC, Yule DI, Williams JA

The American journal of physiology.. 1994 February 266 (2 Pt 1):G303-10. Epub 1900 01 01.

Yule DI, Williams JA

Peptides.. 1994 15 (6):1045-51. Epub 1900 01 01.

Yule DI, Tseng MJ, Williams JA, Logdson CD

The American journal of physiology.. 1993 November 265 (5 Pt 1):G999-1004. Epub 1900 01 01.

Yule DI, Wu D, Essington TE, Shayman JA, Williams JA

The Journal of biological chemistry.. 1993 June 15268 (17):12353-8. Epub 1900 01 01.

Yule DI, Essington TE, Williams JA

The American journal of physiology.. 1993 April 264 (4 Pt 1):G786-91. Epub 1900 01 01.

Wagner AC, Wishart MJ, Yule DI, Williams JA

The American journal of physiology.. 1992 December 263 (6 Pt 1):C1172-80. Epub 1900 01 01.

Yule DI, Blevins GT, Wagner AC, Williams JA

Biochimica et biophysica acta.. 1992 August 121136 (2):175-80. Epub 1900 01 01.

Yule DI, Williams JA

The Journal of biological chemistry.. 1992 July 15267 (20):13830-5. Epub 1900 01 01.

Rapoport SI, Pettigrew KD, Schapiro MB

Neurology.. 1991 October 41 (10):1549-53. Epub 1900 01 01.

Yule DI, Williams JA

Biochemical and biophysical research communications.. 1991 May 31177 (1):159-65. Epub 1900 01 01.

Campistol JM, Montoliu J

Comprehensive therapy.. 1991 February 17 (2):51-62. Epub 1900 01 01.

Petersen OH, Gallacher DV, Wakui M, Yule DI, Petersen CC, Toescu EC

Cell calcium.. 1991 12 (2-3):135-44. Epub 1900 01 01.

Yule DI, Lawrie AM, Gallacher DV

Cell calcium.. 1991 12 (2-3):145-51. Epub 1900 01 01.

Dunne MJ, Yule DI, Gallacher DV, Petersen OH

Biochimica et biophysica acta.. 1990 November 121055 (2):157-64. Epub 1900 01 01.

Gallacher DV, Hanley MR, Petersen OH, Roberts ML, Squire-Pollard LG, Yule DI

The Journal of physiology.. 1990 July 426 :193-207. Epub 1900 01 01.

Osipchuk YV, Wakui M, Yule DI, Gallacher DV, Petersen OH

The EMBO journal.. 1990 March 9 (3):697-704. Epub 1900 01 01.

Dunne MJ, Yule DI, Gallacher DV, Petersen OH

The Journal of membrane biology.. 1990 March 114 (1):53-60. Epub 1900 01 01.

Dunne MJ, Yule DI, Gallacher DV, Petersen OH

The Journal of membrane biology.. 1990 February 113 (2):131-8. Epub 1900 01 01.

Martin SC, Yule DI, Dunne MJ, Gallacher DV, Petersen OH

The EMBO journal.. 1989 December 18 (12):3595-9. Epub 1900 01 01.

Dunne MJ, Yule DI, Gallacher DV, Petersen OH

Pflu?gers Archiv : European journal of physiology.. 1989 414 Suppl 1 :S154-5. Epub 1900 01 01.

Yule DI, Gallacher DV

FEBS letters.. 1988 November 7239 (2):358-62. Epub 1900 01 01.

Books

Physiology of the Gastrointestinal Tract, Two Volume Set (2012)

Chapter: Stimulus-secretion Coupling in Pancreatic Acinar Cells

Authors: Williams, John A., and Yule, David I.

Publisher: Elsevier 2012

Physiology of the Gastrointestinal Tract (2006)

Chapter: Stimulus-Secretion Coupling in the Pancreatic Acinus.

Authors: Williams, JA; and Yule, DI

Publisher: Raven Press 2006

Physiology of the Gastrointestinal Tract (1994)

Chapter: Stimulus-secretion coupling in the pancreatic acinus.

Authors: Yule, DI; and Williams, JA

Publisher: Raven Press 1994

Pancreas: Biology, Pathobiology and Disease (1993)

Chapter: Stimulus-secretion coupling in rat pancreatic acinar cells.

Authors: Williams, JA; Yule, DI; Go, VLW; Dimagn, EP

Publisher: Raven Press, New York 1993