Yi-Tao Yu, Ph.D.
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Yi-Tao Yu, Ph.D.
About Me
Faculty Appointments
Professor - Department of Biochemistry and Biophysics (SMD)
Dean's Professorship - Department of Biochemistry and Biophysics (SMD)
Credentials
Education
PhD | Case Western Reserve University. Molecular Biology. 1994
MS | Shanghai Institute of Physiology, Chinese Academy of Sciences. Neurobiology. 1988
BS | Fudan University. Chemistry. 1982
Post-doctoral training | Department of Molecular Biophysics & Biochemistry, HHMI, Yale University School of Medicine. Molecular Biology. 0
Research
Our recent research has demonstrated that all these three types of RNA can be modified in vivo, either naturally or artificially through the RNA-guided RNA modification mechanisms. Importantly, our experimental data indicate that the posttranscriptional nucleotide modifications contribute significantly to RNA functions. We are currently carrying out three projects, aiming to address some of the fundamental questions regarding RNA modifications.
Patents
Nonsense Suppression and Genetic Codon Alteration by Targeted Modification
Issue date: December 10, 2013
Patent #: 8,603,457
Country: United States
Inventors: Yi-Tao Yu, Xinliang Zhao
Targeted 2'-O-Methylation of Telomerase Non-Coding RNA
Issue date: March 01, 2016
Patent #: 9,273,294
Country: United States
Inventors: Chao Huang, Yi-Tao Yu
Targeted Pre-mRNA/mRNA Modification and Gene Regulation
Issue date: January 19, 2016
Patent #: 9,238,813
Country: United States
Inventors: Yi-Tao Yu, Xinliang Zhao
Publications
Journal Articles
Morais P, Zhang R, Yu YT
Biomedicines.. 2024 June 1012 (6)Epub 06/10/2024.
Pan Y, Adachi H, He X, Chen JL, Yu YT, Boutz PL
Bio-protocol.. 2024 May 514 (9):e4985. Epub 05/05/2024.
Chen JL, Leeder WM, Morais P, Adachi H, Yu YT
The Biochemical journal.. 2024 January 10481 (1):1-16. Epub 1900 01 01.
Adachi H, Pan Y, He X, Chen JL, Klein B, Platenburg G, Morais P, Boutz P, Yu YT
Molecular cell.. 2023 February 1683 (4):637-651.e9. Epub 02/09/2023.
Adachi H, Chen JL, Yin Q, Morais P, Yu YT
Methods in molecular biology.. 2023 2666 :177-191. Epub 1900 01 01.
Adachi H, Hengesbach M, Yu YT, Morais P
Biomedicines.. 2021 May 149 (5)Epub 05/14/2021.
Morais P, Adachi H, Yu YT
Frontiers in genetics.. 2021 12 :652129. Epub 03/02/2021.
Morais P, Adachi H, Yu YT
Frontiers in cell and developmental biology.. 2021 9 :789427. Epub 11/04/2021.
Adachi H, Yu YT
RNA.. 2020 September 26 (9):1247-1256. Epub 05/20/2020.
Morais P, Adachi H, Yu YT
International journal of molecular sciences.. 2020 June 2021 (12)Epub 06/20/2020.
Adachi H, De Zoysa MD, Yu YT
Biochimica et biophysica acta. Gene regulatory mechanisms.. 2019 March 1862 (3):230-239. Epub 11/08/2018.
Adachi H, DeZoysa MD, Yu YT
Methods in molecular biology.. 2019 1870 :219-235. Epub 1900 01 01.
De Zoysa MD, Wu G, Katz R, Yu YT
RNA.. 2018 August 24 (8):1106-1117. Epub 06/05/2018.
Zhao Y, Dunker W, Yu YT, Karijolich J
Frontiers in bioengineering and biotechnology.. 2018 6 :8. Epub 02/08/2018.
Ge J, Karijolich J, Zhai Y, Zheng J, Yu YT
Genes.. 2017 October 318 (11)Epub 10/31/2017.
Poole AR, Vicino I, Adachi H, Yu YT, Hebert MD
Biology open.. 2017 September 156 (9):1342-1354. Epub 09/15/2017.
De Zoysa MD, Yu YT
The Enzymes.. 2017 41 :151-167. Epub 03/11/2017.
Xu C, Ishikawa H, Izumikawa K, Li L, He H, Nobe Y, Yamauchi Y, Shahjee HM, Wu XH, Yu YT, Isobe T, Takahashi N, Min J
Genes & development.. 2016 November 130 (21):2376-2390. Epub 11/10/2016.
Wu G, Radwan MK, Xiao M, Adachi H, Fan J, Yu YT
RNA.. 2016 August 22 (8):1146-52. Epub 06/07/2016.
Huang C, Karijolich J, Yu YT
Methods : a companion to Methods in enzymology.. 2016 July 1103 :68-76. Epub 02/04/2016.
Wu G, Adachi H, Ge J, Stephenson D, Query CC, Yu YT
The EMBO journal.. 2016 March 1535 (6):654-67. Epub 02/12/2016.
Huang C, Wu G, Yu YT
Methods in molecular biology.. 2016 1421 :97-109. Epub 1900 01 01.
Karijolich J, Yi C, Yu YT
Nature reviews. Molecular cell biology.. 2015 October 16 (10):581-5. Epub 08/19/2015.
Karijolich J, Yu YT
RNA.. 2015 April 21 (4):659-60. Epub 1900 01 01.
Enwerem II, Wu G, Yu YT, Hebert MD
PloS one.. 2015 10 (4):e0122348. Epub 04/13/2015.
Wu G, Huang C, Yu YT
Methods in enzymology.. 2015 560 :187-217. Epub 04/27/2015.
Adachi H, Yu YT
World journal of biological chemistry. 2014 November 265 (4):398-408. Epub 1900 01 01.
Karijolich J, Yu YT
International journal of molecular medicine.. 2014 August 34 (2):355-62. Epub 06/17/2014.
Adachi H, Yu YT
Current protocols in molecular biology. 2014 January 6105 :Unit 4.20.. Epub 01/06/2014.
Jun Lim S, Scott A, Xiong XP, Vahidpour S, Karijolich J, Guo D, Pei S, Yu YT, Zhou R, Li W
RNA biology.. 2014 11 (9):1171-9. Epub 1900 01 01.
Yu YT, Meier UT
RNA biology.. 2014 11 (12):1483-94. Epub 1900 01 01.
Fernández IS, Ng CL, Kelley AC, Wu G, Yu YT, Ramakrishnan V
Nature.. 2013 August 1500 (7460):107-10. Epub 06/30/2013.
Ge J, Yu YT
Trends in biochemical sciences.. 2013 April 38 (4):210-8. Epub 02/04/2013.
Huang C, Yu YT
Current protocols in molecular biology. 2013 April Chapter 4 :Unit4.15. Epub 1900 01 01.
Synthesis and labeling of RNA in vitro.
Huang, C; Yu, YT.
Wiley Current Protocols in Molecular Biology. 2013; .
Huang C, Wu G, Yu YT
Nature protocols.. 2012 March 297 (4):789-800. Epub 03/29/2012.
Inducing nonsense suppression by targeted pseudouridylation.
Huang, C; Wu, G; Yu, YT.
Nature Protocols. 2012; 7: 789-800.
Yu AT, Ge J, Yu YT
Protein & cell.. 2011 September 2 (9):712-25. Epub 10/06/2011.
Karijolich J, Yu YT
Nature.. 2011 June 15474 (7351):395-8. Epub 06/15/2011.
Wu G, Xiao M, Yang C, Yu YT
The EMBO journal.. 2011 January 530 (1):79-89. Epub 12/03/2010.
Functions and Mechanisms of Spliceosomal snRNA pseudouridylation.
Wu G; Yu AT; Kantartzis A; Yu YT.
Wiley Interdisciplinary Reviews (WIREs) RNA. 2011; 2: 571-581.
Pseudouridines in spliceosomal snRNAs.
Yu, AT; Ge, J; Yu, YT.
Protein & Cell. 2011; 2: 712-725.
Huang C, Karijolich J, Yu YT
Methods in molecular biology.. 2011 718 :227-44. Epub 1900 01 01.
Wu G, Yu AT, Kantartzis A, Yu YT
Wiley interdisciplinary reviews. RNA.. 2011 2 (4):571-81. Epub 02/18/2011.
Chen C, Zhao X, Kierzek R, Yu YT
Molecular and cellular biology.. 2010 September 30 (17):4108-19. Epub 07/06/2010.
Huang C, Yu YT
Molecular and cellular biology.. 2010 September 30 (18):4368-78. Epub 07/20/2010.
Ge J, Liu H, Yu YT
RNA.. 2010 May 16 (5):1078-85. Epub 03/26/2010.
Karijolich J, Yu YT
RNA biology.. 2010 7 (2):192-204. Epub 03/14/2010.
Karijolich J, Kantartzis A, Yu YT
Methods in molecular biology.. 2010 629 :1-19. Epub 1900 01 01.
Karijolich J, Kantartzis A, Yu YT
Methods in molecular biology.. 2010 629 :21-32. Epub 1900 01 01.
Xiao M, Yang C, Schattner P, Yu YT
RNA.. 2009 January 15 (1):176-86. Epub 11/25/2008.
Spliceosomal snRNA pseudouridylation.
Karijolich, J; Huang, C; Yu, YT.
In DNA and RNA Modification Enzymes: Structure, Mechanism, Function and Evolution (ed. H. Grosjean). Landes Bioscience. 2009; : 461-474.
Karijolich J, Yu YT
Current proteomics. 2008 July 15 (2):129-137. Epub 1900 01 01.
Zhao X, Yu YT
Nature methods.. 2008 January 5 (1):95-100. Epub 12/09/2007.
Functional roles of spliceosomal snRNA modifications in pre-mRNA splicing.
Stephenson, D; Karijolich, J; Yu, YT.
In RNA and DNA Editing: Molecular Mechanisms and Their Integration into Biological Systems (ed. H. Smith). John Wiley & Sons Press, Hoboken, New Jersey, USA. 2008; : 175-189.
Pre-mRNA splicing
Karijolich, J.; Yu, Y.T.;.
Wiley Encyclopedia of Chemical Biology. (ed. TP Begley). 2007; : DOI: 10.1002/9780470048672.wecb520. Article Online Posting.
Zhao X, Yu YT
Nucleic acids research.. 2007 35 (2):550-8. Epub 12/14/2006.
Karijolich J, Stephenson D, Yu YT
Methods in enzymology.. 2007 425 :241-62. Epub 1900 01 01.
Dai Q, Fong R, Saikia M, Stephenson D, Yu YT, Pan T, Piccirilli JA
Nucleic acids research.. 2007 35 (18):6322-9. Epub 09/18/2007.
Yu YT
Structure.. 2006 February 14 (2):167-8. Epub 1900 01 01.
Moon KH, Zhao X, Yu YT
Methods in molecular biology.. 2006 322 :149-63. Epub 1900 01 01.
Ma X, Yang C, Alexandrov A, Grayhack EJ, Behm-Ansmant I, Yu YT
The EMBO journal.. 2005 July 624 (13):2403-13. Epub 06/16/2005.
Yang C, McPheeters DS, Yu YT
The Journal of biological chemistry.. 2005 February 25280 (8):6655-62. Epub 12/20/2004.
Mechanisms and functions of RNA-guided RNA modifications
Yu, Y.-T.; Terns, R. M.; Terns, M. P.;.
In Fine-tuning of RNA functions by modification and editing, Topics in Current Genetics series, vol. 12 (ed. H. Grosjean). Springer-Verlag Press, New York, USA. 2005; : 223-262.
Zhao X, Yu YT
RNA.. 2004 June 10 (6):996-1002. Epub 1900 01 01.
Zhao X, Yu YT
RNA.. 2004 April 10 (4):681-90. Epub 1900 01 01.
Behm-Ansmant I, Urban A, Ma X, Yu YT, Motorin Y, Branlant C
RNA.. 2003 November 9 (11):1371-82. Epub 1900 01 01.
Ma X, Zhao X, Yu YT
The EMBO journal.. 2003 April 1522 (8):1889-97. Epub 1900 01 01.
Zhao X, Li ZH, Terns RM, Terns MP, Yu YT
RNA.. 2002 December 8 (12):1515-25. Epub 1900 01 01.
Yu YT, Shu MD, Narayanan A, Terns RM, Terns MP, Steitz JA
The Journal of cell biology.. 2001 March 19152 (6):1279-88. Epub 1900 01 01.
Yu YT
Methods in enzymology.. 2000 318 :71-88. Epub 1900 01 01.
Yu YT
Methods : a companion to Methods in enzymology.. 1999 May 18 (1):13-21. Epub 1900 01 01.
The growing world of small nuclear ribonucleoprotein particles
Yu, Y.T.; Scharl, E.C.; Smith, C.M.; Steitz, J.A. ;.
In The RNA World, 2nd edition (eds. Gesteland, Cech, and Atkins),Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. 1999; : 487-524.
Yu YT, Shu MD, Steitz JA
The EMBO journal.. 1998 October 117 (19):5783-95. Epub 1900 01 01.
Lapham J, Yu YT, Shu MD, Steitz JA, Crothers DM
RNA.. 1997 September 3 (9):950-1. Epub 1900 01 01.
Yu YT, Steitz JA
RNA.. 1997 July 3 (7):807-10. Epub 1900 01 01.
Yu YT, Steitz JA
Proceedings of the National Academy of Sciences of the United States of America.. 1997 June 1094 (12):6030-5. Epub 1900 01 01.
Yu YT, Shu MD, Steitz JA
RNA.. 1997 March 3 (3):324-31. Epub 1900 01 01.
Yu YT, Tarn WY, Yario TA, Steitz JA
Experimental cell research.. 1996 December 15229 (2):276-81. Epub 1900 01 01.
Maroney PA, Yu YT, Jankowska M, Nilsen TW
RNA.. 1996 August 2 (8):735-45. Epub 1900 01 01.
Denker JA, Maroney PA, Yu YT, Kanost RA, Nilsen TW
RNA.. 1996 August 2 (8):746-55. Epub 1900 01 01.
Yu YT, Maroney PA, Darzynkiwicz E, Nilsen TW
RNA.. 1995 March 1 (1):46-54. Epub 1900 01 01.
Yu YT, Maroney PA, Nilsen TW
Cell.. 1993 December 1775 (6):1049-59. Epub 1900 01 01.
Hannon GJ, Maroney PA, Yu YT, Hannon GE, Nilsen TW
Science.. 1992 December 11258 (5089):1775-80. Epub 1900 01 01.
Yu YT, Nilsen TW
The Journal of biological chemistry.. 1992 May 5267 (13):9264-8. Epub 1900 01 01.
Books
DNA and RNA Modification Enzymes: Structure, Mechanism, Function and Evolution (2009)
Chapter: Spliceosomal snRNA pseudouridylation
Authors: Karijolich, J., Huang, C. and Yu, Y.-T.
Publisher: Landes Bioscience, Austin, Texas 2009
RNA and DNA Editing: Molecular Mechanisms and Their Integration into Biological (2008)
Chapter: Functional roles of spliceosomal snRNA modifications in pre-mRNA splicing
Authors: Stephenson, D., Karijolich, J. and Yu, Y.-T.
Publisher: John Wiley & Sons Press, Hoboken, New Jersey 2008