Alison Elder, Ph.D.
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Alison Elder, Ph.D.
About Me
Faculty Appointments
Associate Professor - Department of Environmental Medicine (SMD)
Credentials
Post-doctoral Training & Residency
Post-doctoral Fellow, Department of Environmental Medicine, University of Rochester 1997 - 2000
Education
PhD | Univ of Cal Irvine. Environmental Toxicology. 1997
BS | Chatham College. Chemistry. 1992
Awards
Young Investigator Award, Inhalation and Respiratory Specialty Section, Society of Toxicology. 2009
Cornerstone Alumna Award in Environmental Medicine, Chatham University. 2007
Graduate Student Fellowship, U.S. Environmental Protection Agency. 1995 - 1996
College Chemistry Award, Society for Analytical Chemists of Pittsburgh. 1992
Research
Our laboratory has focused for several years on the toxicology of inhaled ultrafine particles (UFPs), the most numerous size fraction of particulate air pollution. Interests include the impacts of age, gaseous co-pollutant...
Our laboratory has focused for several years on the toxicology of inhaled ultrafine particles (UFPs), the most numerous size fraction of particulate air pollution. Interests include the impacts of age, gaseous co-pollutant exposure, and health status on the response(s) to inhaled UFPs. We are also interested in determining the basis for potential adverse effects of inhaled particles in the cardiovascular and central nervous systems.
This research focus has naturally led to our work with engineered nanomaterials. The research commonalities between UFP and nanomaterials are numerous, including the kinetics of tissue distribution following exposure, mechanisms of response related to oxidative stress, particle-protein interactions, and the physicochemical characteristics of the particles that determine response. Our research aims are met by using a combination of animal and cell culture models as well as detailed particle characterization.
In addition to looking for nanosized particles in tissues via chemical and microscopic means, responses are determined by measuring markers of inflammation and oxidative stress in the lung lining fluid, lung tissue, blood, circulating inflammatory cells, and extrapulmonary tissues (e.g. heart, liver, spleen, kidney, brain regions). We also have specific projects focused on cardiovascular stability and neurodegeneration following exposures to UFPs and nanomaterials.
Publications
Journal Articles
Morgan SE, Romanick SS, DeLouise L, McGrath J, Elder A
Current protocols.. 2024 July 4 (7):e1104. Epub 1900 01 01.
Hussain R, Graham U, Elder A, Nedergaard M
Trends in neurosciences.. 2023 November 46 (11):901-911. Epub 09/28/2023.
Borm PJA, Lison D, Driscoll K, Duffin R, Harkema J, Weber K, Elder A
Frontiers in public health.. 2022 10 :869041. Epub 05/25/2022.
Herr D, Jew K, Wong C, Kennell A, Gelein R, Chalupa D, Raab A, Oberdörster G, Olschowka J, O'Banion MK, Elder A
Neurotoxicology.. 2021 May 84 :172-183. Epub 03/29/2021.
Keller JG, Graham UM, Koltermann-Jülly J, Gelein R, Ma-Hock L, Landsiedel R, Wiemann M, Oberdörster G, Elder A, Wohlleben W
Scientific reports.. 2021 April 1911 (1):8813. Epub 04/19/2021.
Knudsen TB, Fitzpatrick SC, De Abrew KN, Birnbaum LS, Chappelle A, Daston GP, Dolinoy DC, Elder A, Euling S, Faustman EM, Fedinick KP, Franzosa JA, Haggard DE, Haws L, Kleinstreuer N, Louis GMB, Mendrick DL, Rudel R, Saili KS, Schug TT, Tanguay RL, Turley AE, Wetmore BA, White KW, Zurlinden TJ
Toxicological sciences : an official journal of the Society of Toxicology.. 2021 April 12180 (2):198-211. Epub 1900 01 01.
Smyth T, Veazey J, Eliseeva S, Chalupa D, Elder A, Georas SN
Particle and fibre toxicology.. 2020 October 1517 (1):52. Epub 10/15/2020.
Keller JG, Graham UM, Koltermann-Jülly J, Gelein R, Ma-Hock L, Landsiedel R, Wiemann M, Oberdörster G, Elder A, Wohlleben W
Scientific reports.. 2020 January 1610 (1):458. Epub 01/16/2020.
Jew K, Herr D, Wong C, Kennell A, Morris-Schaffer K, Oberdörster G, O'Banion MK, Cory-Slechta DA, Elder A
Particle and fibre toxicology.. 2019 November 2616 (1):45. Epub 11/26/2019.
Riediker M, Zink D, Kreyling W, Oberdörster G, Elder A, Graham U, Lynch I, Duschl A, Ichihara G, Ichihara S, Kobayashi T, Hisanaga N, Umezawa M, Cheng TJ, Handy R, Gulumian M, Tinkle S, Cassee F
Particle and fibre toxicology.. 2019 June 2716 (1):26. Epub 06/27/2019.
Riediker M, Zink D, Kreyling W, Oberdörster G, Elder A, Graham U, Lynch I, Duschl A, Ichihara G, Ichihara S, Kobayashi T, Hisanaga N, Umezawa M, Cheng TJ, Handy R, Gulumian M, Tinkle S, Cassee F
Particle and fibre toxicology.. 2019 April 2316 (1):19. Epub 04/23/2019.
Morris-Schaffer K, Merrill A, Jew K, Wong C, Conrad K, Harvey K, Marvin E, Sobolewski M, Oberdörster G, Elder A, Cory-Slechta DA
Particle and fibre toxicology.. 2019 February 1816 (1):10. Epub 02/18/2019.
Stone V, Miller MR, Clift MJD, Elder A, Mills NL, Møller P, Schins RPF, Vogel U, Kreyling WG, Alstrup Jensen K, Kuhlbusch TAJ, Schwarze PE, Hoet P, Pietroiusti A, De Vizcaya-Ruiz A, Baeza-Squiban A, Teixeira JP, Tran CL, Cassee FR
Environmental health perspectives.. 2017 October 10125 (10):106002. Epub 10/10/2017.
Shi M, de Mesy Bentley KL, Palui G, Mattoussi H, Elder A, Yang H
Nanoscale.. 2017 April 69 (14):4739-4750. Epub 1900 01 01.
Graham UM, Jacobs G, Yokel RA, Davis BH, Dozier AK, Birch ME, Tseng MT, Oberdörster G, Elder A, DeLouise L
Advances in experimental medicine and biology.. 2017 947 :71-100. Epub 1900 01 01.
McCarthy CE, Duffney PF, Gelein R, Thatcher TH, Elder A, Phipps RP, Sime PJ
American journal of physiology. Lung cellular and molecular physiology.. 2016 December 1311 (6):L1222-L1233. Epub 11/11/2016.
Stone V, Miller MR, Clift MJ, Elder A, Mills NL, Møller P, Schins RP, Vogel U, Kreyling WG, Jensen KA, Kuhlbusch TA, Schwarze PE, Hoet P, Pietroiusti A, De Vizcaya-Ruiz A, Baeza-Squiban A, Tran CL, Cassee FR
Environmental health perspectives.. 2016 November 4 Epub 11/04/2016.
Guttenberg M, Bezerra L, Neu-Baker NM, Del Pilar Sosa Idelchik M, Elder A, Oberdörster G, Brenner SA
Journal of biophotonics.. 2016 October 9 (10):987-993. Epub 08/16/2016.
Lerner CA, Rutagarama P, Ahmad T, Sundar IK, Elder A, Rahman I
Biochemical and biophysical research communications.. 2016 September 2477 (4):620-625. Epub 06/23/2016.
Lerner CA, Sundar IK, Watson RM, Elder A, Jones R, Done D, Kurtzman R, Ossip DJ, Robinson R, McIntosh S, Rahman I
Environmental pollution.. 2015 March 198 :100-7. Epub 01/09/2015.
Gordon SC, Butala JH, Carter JM, Elder A, Gordon T, Gray G, Sayre PG, Schulte PA, Tsai CS, West J
Regulatory toxicology and pharmacology : RTP.. 2014 April 68 (3):305-11. Epub 01/23/2014.
Sotiriou GA, Watson C, Murdaugh KM, Darrah TH, Pyrgiotakis G, Elder A, Brain JD, Demokritou P
Environmental science. Nano.. 2014 April 1 (2):144-153. Epub 1900 01 01.
Baisch BL, Corson NM, Wade-Mercer P, Gelein R, Kennell AJ, Oberdörster G, Elder A
Particle and fibre toxicology.. 2014 January 2411 :5. Epub 01/24/2014.
Mortensen LJ, Jatana S, Gelein R, Debenedetto A, de Mesy Bentley KL, Beck L, Elder A, Delouise L
Nanotoxicology.. 2013 December 7 (8):1386-98. Epub 04/17/2013.
Doudrick K, Corson N, Oberdörster G, Elder AC, Herckes P, Halden RU, Westerhoff P
ACS nano.. 2013 October 227 (10):8849-56. Epub 09/06/2013.
Baer DR, Engelhard MH, Johnson GE, Laskin J, Lai J, Mueller K, Munusamy P, Thevuthasan S, Wang H, Washton N, Elder A, Baisch BL, Karakoti A, Kuchibhatla SV, Moon D
Journal of vacuum science & technology. A, Vacuum, surfaces, and films : an official journal of the American Vacuum Society.. 2013 September 31 (5):50820. Epub 08/27/2013.
Bonner JC, Silva RM, Taylor AJ, Brown JM, Hilderbrand SC, Castranova V, Porter D, Elder A, Oberdörster G, Harkema JR, Bramble LA, Kavanagh TJ, Botta D, Nel A, Pinkerton KE
Environmental health perspectives.. 2013 June 121 (6):676-82. Epub 05/06/2013.
Xia T, Hamilton RF, Bonner JC, Crandall ED, Elder A, Fazlollahi F, Girtsman TA, Kim K, Mitra S, Ntim SA, Orr G, Tagmount M, Taylor AJ, Telesca D, Tolic A, Vulpe CD, Walker AJ, Wang X, Witzmann FA, Wu N, Xie Y, Zink JI, Nel A, Holian A
Environmental health perspectives.. 2013 June 121 (6):683-90. Epub 05/06/2013.
Block ML, Elder A, Auten RL, Bilbo SD, Chen H, Chen JC, Cory-Slechta DA, Costa D, Diaz-Sanchez D, Dorman DC, Gold DR, Gray K, Jeng HA, Kaufman JD, Kleinman MT, Kirshner A, Lawler C, Miller DS, Nadadur SS, Ritz B, Semmens EO, Tonelli LH, Veronesi B, Wright RO, Wright RJ
Neurotoxicology.. 2012 October 33 (5):972-84. Epub 09/05/2012.
Lucchini RG, Dorman DC, Elder A, Veronesi B
Neurotoxicology.. 2012 August 33 (4):838-41. Epub 12/09/2011.
Han X, Corson N, Wade-Mercer P, Gelein R, Jiang J, Sahu M, Biswas P, Finkelstein JN, Elder A, Oberdörster G
Toxicology.. 2012 July 16297 (1-3):1-9. Epub 04/02/2012.
Shi M, Kwon HS, Peng Z, Elder A, Yang H
ACS nano.. 2012 March 276 (3):2157-64. Epub 03/05/2012.
Han X, Gelein R, Corson N, Wade-Mercer P, Jiang J, Biswas P, Finkelstein JN, Elder A, Oberdörster G
Toxicology.. 2011 September 5287 (1-3):99-104. Epub 06/23/2011.
Rivera Gil P, Oberdörster G, Elder A, Puntes V, Parak WJ
ACS nano.. 2010 October 264 (10):5527-31. Epub 1900 01 01.
Gillespie PA, Kang GS, Elder A, Gelein R, Chen L, Moreira AL, Koberstein J, Tchou-Wong KM, Gordon T, Chen LC
Nanotoxicology.. 2010 March 14 (1):106-119. Epub 1900 01 01.
Kim SC, Chen DR, Qi C, Gelein RM, Finkelstein JN, Elder A, Bentley K, Oberdörster G, Pui DY
Nanotoxicology.. 2010 March 4 (1):42-51. Epub 1900 01 01.
A nanoparticle dispersion method of in vitro and in vivo nanotoxicity study
Kim, S.C.; Chen, D.; Qi, C.; Gelein, R.M.; Finkelstein, J.N.; Elder, A.; Bentley, K.; Oberdorster, G.; Pui, D.Y.H.
Nanotoxicology. 2010; 4(1): 42-51.
Pulmonary response after exposure to inhaled nickel hydroxide nanoparticles: short and long-term studies in mice
Gillespie, P.A.; Kang, G.S.; Elder, A.; Gelein, R.; Chen, L.; Moreira, A.L.; Koberstein, J.; Tchou-Wang, K.M.; Gordon, T.; Chen, L.C.
Nanotoxicology. 2010; 4(1): 106-19.
Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, Elder A, Han X, Gelein R, Finkelstein J, Oberdorster G
Journal of toxicology and environmental health. Part A.. 2010 73 (5):445-61. Epub 1900 01 01.
Oberdörster G, Elder A, Rinderknecht A
Journal of nanoscience and nanotechnology.. 2009 August 9 (8):4996-5007. Epub 1900 01 01.
Elder A
Nature nanotechnology.. 2009 July 4 (7):409-10. Epub 06/14/2009.
Linkov I, Steevens J, Adlakha-Hutcheon G, Bennett E, Chappell M, Colvin V, Davis JM, Davis T, Elder A, Foss Hansen S, Hakkinen PB, Hussain SM, Karkan D, Korenstein R, Lynch I, Metcalfe C, Ramadan AB, Satterstrom FK
Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology.. 2009 April 11 (3):513-527. Epub 10/08/2008.
Vanwinkle BA, de Mesy Bentley KL, Malecki JM, Gunter KK, Evans IM, Elder A, Finkelstein JN, Oberdörster G, Gunter TE
Nanotoxicology.. 2009 January 13 (4):307-318. Epub 1900 01 01.
Elder A, Vidyasagar S, DeLouise L
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.. 2009 1 (4):434-50. Epub 1900 01 01.
Jiang J, Oberdörster G, Elder A, Gelein R, Mercer P, Biswas P
Nanotoxicology.. 2008 March 2 (1):33-42. Epub 1900 01 01.
Does nanoparticles activity depend on size and crystal phase?
Jiang, J.; Oberdorster, G.; Elder, A.; Gelein, R.; Mercer, P.; Biswas, P.
Nanotoxicology. 2008; 2(1): 33-42.
Elder A, Couderc JP, Gelein R, Eberly S, Cox C, Xia X, Zareba W, Hopke P, Watts W, Kittelson D, Frampton M, Utell M, Oberdörster G
Inhalation toxicology.. 2007 January 19 (1):1-12. Epub 1900 01 01.
A Testing Strategy for Nanomaterials of Unknown Toxicity: An Example using Platinum Nanoparticles of Different Shapes.
Elder, A.; Yang, H.; Gwizada, R.; Teng, X.; Thurston, S.; He, H.; Oberdörster, G.
Adv. Mater. 2007; .
Nasal Toxicity in Laboratory Rats After Subchronic Inhalation Exposure to Carbon Black Nanoparticles
Santhanam, P.; J.G. Wagner; A. Elder; R. Gelein; J.M. Carter; K.E. Driscoll; G. Oberdörster; J.R. Harkema.
Int'l. J. Nanotechnol. 2007; .
Carter JM, Corson N, Driscoll KE, Elder A, Finkelstein JN, Harkema JN, Gelein R, Wade-Mercer P, Nguyen K, Oberdorster G
Journal of occupational and environmental medicine. 2006 December 48 (12):1265-78. Epub 1900 01 01.
Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdörster G
Environmental health perspectives.. 2006 August 114 (8):1172-8. Epub 1900 01 01.
Elder A, Oberdörster G
Clinics in occupational and environmental medicine. 2006 5 (4):785-96. Epub 1900 01 01.
Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Oberdörster G
Toxicological sciences : an official journal of the Society of Toxicology.. 2005 December 88 (2):614-29. Epub 09/21/2005.
Silva VM, Corson N, Elder A, Oberdörster G
Toxicological sciences : an official journal of the Society of Toxicology.. 2005 June 85 (2):983-9. Epub 03/16/2005.
Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdörster G
Experimental lung research.. 2005 31 (6):527-46. Epub 1900 01 01.
Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C
Inhalation toxicology.. 2004 June 16 (6-7):437-45. Epub 1900 01 01.
Elder AC, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdörster G
Inhalation toxicology.. 2004 June 16 (6-7):461-71. Epub 1900 01 01.
Elder AC, Gelein R, Oberdörster G, Finkelstein J, Notter R, Wang Z
Experimental lung research.. 2004 March 30 (2):105-20. Epub 1900 01 01.
Kittelson DB, Watts WF, Johnson JP, Remerowki ML, Ische EE, Oberdörster G, Gelein RM, Elder A, Hopke PK, Kim E, Zhao W, Zhou L, Jeong CH
Inhalation toxicology.. 2004 16 Suppl 1 :31-9. Epub 1900 01 01.
Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong CH, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdörster G
Inhalation toxicology.. 2004 16 Suppl 1 :41-53. Epub 1900 01 01.
Johnston CJ, Williams JP, Elder A, Hernady E, Finkelstein JN
Experimental lung research.. 2004 30 (5):369-82. Epub 1900 01 01.
Gallagher J, Sams R, Inmon J, Gelein R, Elder A, Oberdörster G, Prahalad AK
Toxicology and applied pharmacology.. 2003 August 1190 (3):224-31. Epub 1900 01 01.
Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Lunts A, Kreyling W, Cox C
Journal of toxicology and environmental health. Part A.. 2002 October 2565 (20):1531-43. Epub 1900 01 01.
Systemic Interactions Between Inhaled Ultrafine Particles and Endotoxin
Elder, A.C.P.; Gelein, R.; Azadniv, M.; Frampton, M.; Oberdörster, G.
Ann. Occup. Hyg. 2002; 46(Suppl. 1): 231-234.
Limitations of Power Spectrum Analysis and Time-Domain Analysis of Heart Rate Variability in Short-Term ECGs Recorded using Telemetry in Unrestrained Rats
Couderc, J-P.; Elder, A.; Cox, C.; Zareba, W.; Oberdörster, G.
Comp. Cardiol. 2002; 29: 589-592.
Oberdörster G, Finkelstein JN, Johnston C, Gelein R, Cox C, Baggs R, Elder AC
Research report. 2000 August (96):5-74; disc. 75-86. Epub 1900 01 01.
Elder AC, Finkelstein J, Johnston C, Gelein R, Oberdörster G
Inhalation toxicology.. 2000 March 12 (3):225-43. Epub 1900 01 01.
Endotoxin Priming Affects the Lung Response to Ultrafine Particles and Ozone in Young and Old Rats
Elder, A.C.P.; Gelein, R.; Finkelstein, J.N.; Cox, C.; Oberdörster, G.
Inhal. Toxicol. 2000; 12(Suppl. 1): 85-98.
Elder AC, Gelein R, Finkelstein JN, Cox C, Oberdörster G
Inhalation toxicology.. 2000 12 Suppl 4 :227-46. Epub 1900 01 01.
Pearson AC, Bhalla DK
Journal of toxicology and environmental health.. 1997 February 750 (2):143-57. Epub 1900 01 01.
Bhalla DK, Hoffman LA, Pearson AC
Annals of the New York Academy of Sciences.. 1996 October 31796 :38-46. Epub 1900 01 01.
Books
Particles and Cardiovascular Disease Mechanisms (2010)
Chapter: Particles and the autonomic nervous system
Authors: Upadhyay S, Elder A, Cascio WE, Schulz H
Publisher: John Wiley & Sons, Inc., Hoboken, NJ 2010
Nanotechnology: Risks and Benefits (2009)
Chapter: Human Health Risks of Engineered Nanomaterials
Authors: Elder A, Lynch I, Grieger K, Chan-Remillard S, Gatti A, Gnewuch H, Kenawy E, Korenstein R, Kuhlbusch T, Linker F, Matias S, Monteiro-Riviere N, Pinto V, Rudnitsky R, Savoleinen K, Shvedova A
Publisher: Springer, Dordrecht 2009
Nanotechnology: Risks and Benefits (2009)
Chapter: Disposition of Nanoparticles as a Function of their Interactions with Biomolecules
Authors: Lynch I, Elder A
Publisher: Springer, Dordrecht 2009
Safety of Nanoparticles (2008)
Chapter: Breeching Epithelial Barriers – Physiochemical Factors Impacting Nanomaterial Translocation and Toxicity
Authors: DeLouise L, Mortensen L, Elder A
Publisher: Springer 2008
Effects of Air Contaminants on the Respiratory Tract - Interpretations from Mole (2004)
Chapter: Effects of inhaled fine/ultrafine particles combined with other air pollutants
Authors: Elder, A.C.P.; Gelein, R.; Finkelstein, J.; Frampton, M.; Utell, M.; Carter, J.; Driscoll, K.; Kittelson, D.; Watts, W.; Hopke, P.; Vincent, R.' Kumarathasan, P.; Oberdorster, G.
Publisher: Fraunhofer IRB Verlag, Stuttgart 2004