Joseph E. Wedekind, Ph.D.
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Joseph E. Wedekind, Ph.D.
About Me
Faculty Appointments
Professor - Department of Biochemistry and Biophysics (SMD)
Credentials
Post-doctoral Training & Residency
RNA Biophysics, Dept. of Structural Biology, Stanford University School of Medicine. 1995-1999 1995 - 1999
Education
Ph.D. | University of Wisconsin at Madison. Biochemistry (Structural Enzymology). 1995
B.Sc. | University of California at Riverside. Biochemistry (Magna Cum Laude). 1990
Awards
Member, MSFB Study Section. 2018 - 2022
Secretary, Medical Faculty Council. 2017 - 2019
Faculty Teaching Award in Biophysics. 2015
Editorial Board Member, The Journal of Biological Chemistry. 2011 - 2016
Executive Committee Member, CHESS Users' Group. 2010 - 2012
Faculty Teaching Award in Biophysics. 2010
Elected Secretary (The Board of Directors). 2007 - 2009
Faculty Teaching Award in Biophysics. 2005
Life Sciences Research Foundation Fellow. 1996 - 1999
Individual NRSA Post-doctoral Fellowship (declined). 1996
Leukemia and Lymphoma Society Post-Doctoral Award (declined). 1996
Dean's Fellow. 1995 - 1996
NIH Biophysics Training Grant Recipient. 1992 - 1995
Elected Member, Phi Beta Kappa. 1990
Edmondson Summer Research Fellow. 1989
Research
Our lab employs a variety of biochemical, biophysical, and structural approaches, such as X-ray crystallography. We greatly acknowledge NIH/NCRR award S10 RR026501 for supporting this instrumentation. For access or further information see: /structural-biology-biophysics.aspx
Publications
Journal Articles
Srivastava Y, Blau ME, Jenkins JL, Wedekind JE
Biochemistry.. 2023 December 562 (23):3396-3410. Epub 11/10/2023.
Kretsch RC, Andersen ES, Bujnicki JM, Chiu W, Das R, Luo B, Masquida B, McRae EKS, Schroeder GM, Su Z, Wedekind JE, Xu L, Zhang K, Zheludev IN, Moult J, Kryshtafovych A
Proteins.. 2023 December 91 (12):1600-1615. Epub 07/19/2023.
Schroeder GM, Kiliushik D, Jenkins JL, Wedekind JE
The Journal of biological chemistry.. 2023 October 299 (10):105208. Epub 09/01/2023.
Wedekind JE
Journal of molecular biology.. 2023 May 15435 (10):168087. Epub 04/07/2023.
Schroeder GM, Akinyemi O, Malik J, Focht CM, Pritchett EM, Baker CD, McSally JP, Jenkins JL, Mathews DH, Wedekind JE
Nucleic acids research.. 2023 March 2151 (5):2464-2484. Epub 1900 01 01.
Cavender CE, Schroeder GM, Mathews DH, Wedekind JE
Methods in molecular biology.. 2023 2568 :53-73. Epub 1900 01 01.
Schroeder GM, Cavender CE, Blau ME, Jenkins JL, Mathews DH, Wedekind JE
Nature communications.. 2022 January 1113 (1):199. Epub 01/11/2022.
Chavali SS, Mali SM, Bonn R, Saseendran A, Bennett RP, Smith HC, Fasan R, Wedekind JE
The Journal of biological chemistry.. 2021 December 297 (6):101390. Epub 11/09/2021.
Srivastava Y, Bonn-Breach R, Chavali SS, Lippa GM, Jenkins JL, Wedekind JE
Crystals.. 2021 March 11 (3)Epub 03/10/2021.
Chavali SS, Mali SM, Jenkins JL, Fasan R, Wedekind JE
The Journal of biological chemistry.. 2020 December 4295 (49):16470-16486. Epub 1900 01 01.
Chavali SS, Cavender CE, Mathews DH, Wedekind JE
Journal of the American Chemical Society.. 2020 November 25142 (47):19835-19839. Epub 11/10/2020.
Schroeder GM, Dutta D, Cavender CE, Jenkins JL, Pritchett EM, Baker CD, Ashton JM, Mathews DH, Wedekind JE
Nucleic acids research.. 2020 August 2048 (14):8146-8164. Epub 1900 01 01.
Dutta D, Wedekind JE
The Journal of biological chemistry.. 2020 February 28295 (9):2555-2567. Epub 10/28/2019.
Bonn-Breach R, Gu Y, Jenkins J, Fasan R, Wedekind J
Acta crystallographica. Section D, Structural biology.. 2019 November 175 (Pt 11):969-979. Epub 10/30/2019.
Warnasooriya C, Ling C, Belashov IA, Salim M, Wedekind JE, Ermolenko DN
RNA biology.. 2019 September 16 (9):1086-1092. Epub 10/30/2018.
Chavali SS, Bonn-Breach R, Wedekind JE
The Journal of biological chemistry.. 2019 June 14294 (24):9326-9341. Epub 05/12/2019.
Dutta D, Belashov IA, Wedekind JE
Biochemistry.. 2018 August 757 (31):4620-4628. Epub 06/26/2018.
Belashov IA, Crawford DW, Cavender CE, Dai P, Beardslee PC, Mathews DH, Pentelute BL, McNaughton BR, Wedekind JE
Nucleic acids research.. 2018 July 2746 (13):6401-6415. Epub 1900 01 01.
Wedekind JE, Dutta D, Belashov IA, Jenkins JL
The Journal of biological chemistry.. 2017 June 9292 (23):9441-9450. Epub 04/28/2017.
Jenkins JL, Wedekind JE
Methods in molecular biology.. 2016 1490 :265-80. Epub 1900 01 01.
Dutta D, Wedekind JE
Journal of molecular biology.. 2015 November 6427 (22):3469-3472. Epub 08/06/2015.
Aytenfisu AH, Liberman JA, Wedekind JE, Mathews DH
RNA.. 2015 November 21 (11):1898-907. Epub 09/14/2015.
Liberman JA, Suddala KC, Aytenfisu A, Chan D, Belashov IA, Salim M, Mathews DH, Spitale RC, Walter NG, Wedekind JE
Proceedings of the National Academy of Sciences of the United States of America.. 2015 July 7112 (27):E3485-94. Epub 06/23/2015.
Heldenbrand H, Janowski PA, Giamba?u G, Giese TJ, Wedekind JE, York DM
Journal of the American Chemical Society.. 2014 June 4136 (22):7789-92. Epub 05/23/2014.
Liberman JA, Bogue JT, Jenkins JL, Salim M, Wedekind JE
Methods in enzymology.. 2014 549 :435-50. Epub 1900 01 01.
Suddala KC, Rinaldi AJ, Feng J, Mustoe AM, Eichhorn CD, Liberman JA, Wedekind JE, Al-Hashimi HM, Brooks CL, Walter NG
Nucleic acids research.. 2013 December 41 (22):10462-75. Epub 09/03/2013.
Can M, Krucinska J, Zoppellaro G, Andersen NH, Wedekind JE, Hersleth HP, Andersson KK, Bren KL
Chembiochem : a European journal of chemical biology.. 2013 September 2314 (14):1828-38. Epub 07/31/2013.
Liberman JA, Salim M, Krucinska J, Wedekind JE
Nature chemical biology.. 2013 June 9 (6):353-5. Epub 04/14/2013.
Wang W, Maucuer A, Gupta A, Manceau V, Thickman KR, Bauer WJ, Kennedy SD, Wedekind JE, Green MR, Kielkopf CL
Structure.. 2013 February 521 (2):197-208. Epub 12/27/2012.
Salter JD, Lippa GM, Belashov IA, Wedekind JE
Biochemistry.. 2012 November 651 (44):8702-4. Epub 10/25/2012.
Banáš P, Sklenovský P, Wedekind JE, Sponer J, Otyepka M
The journal of physical chemistry. B. 2012 October 25116 (42):12721-34. Epub 10/12/2012.
Liberman JA, Guo M, Jenkins JL, Krucinska J, Chen Y, Carey PR, Wedekind JE
Journal of the American Chemical Society.. 2012 October 17134 (41):16933-6. Epub 10/03/2012.
Liberman JA, Wedekind JE
Wiley interdisciplinary reviews. RNA.. 2012 3 (3):369-84. Epub 09/28/2011.
Lippa GM, Liberman JA, Jenkins JL, Krucinska J, Salim M, Wedekind JE
Methods in molecular biology.. 2012 848 :159-84. Epub 1900 01 01.
Jenkins JL, Krucinska J, McCarty RM, Bandarian V, Wedekind JE
The Journal of biological chemistry.. 2011 July 15286 (28):24626-37. Epub 05/18/2011.
Liberman JA, Wedekind JE
Current opinion in structural biology.. 2011 June 21 (3):327-34. Epub 04/27/2011.
Wedekind JE
Structure.. 2010 July 1418 (7):757-8. Epub 1900 01 01.
Salter JD, Krucinska J, Raina J, Smith HC, Wedekind JE
Biochemistry.. 2009 November 1748 (45):10685-7. Epub 1900 01 01.
Spitale RC, Wedekind JE
Methods : a companion to Methods in enzymology.. 2009 October 49 (2):87-100. Epub 06/24/2009.
Guo M, Spitale RC, Volpini R, Krucinska J, Cristalli G, Carey PR, Wedekind JE
Journal of the American Chemical Society.. 2009 September 16131 (36):12908-9. Epub 1900 01 01.
Spitale RC, Volpini R, Mungillo MV, Krucinska J, Cristalli G, Wedekind JE
Biochemistry.. 2009 August 2548 (33):7777-9. Epub 1900 01 01.
Spitale RC, Volpini R, Heller MG, Krucinska J, Cristalli G, Wedekind JE
Journal of the American Chemical Society.. 2009 May 6131 (17):6093-5. Epub 1900 01 01.
Spitale RC, Torelli AT, Krucinska J, Bandarian V, Wedekind JE
The Journal of biological chemistry.. 2009 April 24284 (17):11012-6. Epub 03/04/2009.
Bennett RP, Salter JD, Liu X, Wedekind JE, Smith HC
The Journal of biological chemistry.. 2008 November 28283 (48):33329-36. Epub 10/08/2008.
MacElrevey C, Salter JD, Krucinska J, Wedekind JE
RNA.. 2008 August 14 (8):1600-16. Epub 07/02/2008.
Torelli AT, Spitale RC, Krucinska J, Wedekind JE
Biochemical and biophysical research communications.. 2008 June 20371 (1):154-8. Epub 04/16/2008.
Jamburuthugoda VK, Santos-Velazquez JM, Skasko M, Operario DJ, Purohit V, Chugh P, Szymanski EA, Wedekind JE, Bambara RA, Kim B
The Journal of biological chemistry.. 2008 April 4283 (14):9206-16. Epub 01/24/2008.
Bennett RP, Presnyak V, Wedekind JE, Smith HC
The Journal of biological chemistry.. 2008 March 21283 (12):7320-7. Epub 12/28/2007.
Spitale RC, Heller MG, Pelly AJ, Wedekind JE
The Journal of organic chemistry.. 2007 October 2672 (22):8551-4. Epub 09/29/2007.
Torelli AT, Krucinska J, Wedekind JE
RNA.. 2007 July 13 (7):1052-70. Epub 05/08/2007.
MacElrevey C, Spitale RC, Krucinska J, Wedekind JE
Acta crystallographica. Section D, Biological crystallography.. 2007 July 63 (Pt 7):812-25. Epub 06/15/2007.
Lehmann DM, Galloway CA, MacElrevey C, Sowden MP, Wedekind JE, Smith HC
Biochimica et biophysica acta.. 2007 March 1773 (3):408-18. Epub 12/08/2006.
Wedekind JE, Gillilan R, Janda A, Krucinska J, Salter JD, Bennett RP, Raina J, Smith HC
The Journal of biological chemistry.. 2006 December 15281 (50):38122-6. Epub 10/31/2006.
Bennett RP, Diner E, Sowden MP, Lees JA, Wedekind JE, Smith HC
Biochemical and biophysical research communications.. 2006 November 10350 (1):214-9. Epub 09/18/2006.
Ghosh AK, Sridhar PR, Leshchenko S, Hussain AK, Li J, Kovalevsky AY, Walters DE, Wedekind JE, Grum-Tokars V, Das D, Koh Y, Maeda K, Gatanaga H, Weber IT, Mitsuya H
Journal of medicinal chemistry.. 2006 August 2449 (17):5252-61. Epub 1900 01 01.
Ichikawa HT, Sowden MP, Torelli AT, Bachl J, Huang P, Dance GS, Marr SH, Robert J, Wedekind JE, Smith HC, Bottaro A
The Journal of immunology : official journal of the American Association of Immunologists.. 2006 July 1177 (1):355-61. Epub 1900 01 01.
Chaves FA, Richards KA, Torelli A, Wedekind J, Sant AJ
Biochemistry.. 2006 May 2345 (20):6426-33. Epub 1900 01 01.
Salter J, Krucinska J, Alam S, Grum-Tokars V, Wedekind JE
Biochemistry.. 2006 January 2445 (3):686-700. Epub 1900 01 01.
MacElrevey C, Wedekind JE
Acta crystallographica. Section F, Structural biology and crystallization communications.. 2005 December 161 (Pt 12):1049-53. Epub 11/12/2005.
Alam S, Grum-Tokars V, Krucinska J, Kundracik ML, Wedekind JE
Biochemistry.. 2005 November 844 (44):14396-408. Epub 1900 01 01.
Xie K, Song SC, Spitalnik SL, Wedekind JE
Acta crystallographica. Section D, Biological crystallography.. 2005 October 61 (Pt 10):1386-94. Epub 09/28/2005.
Gruswitz F, Frishman M, Goldstein BM, Wedekind JE
BioTechniques.. 2005 October 39 (4):476, 478, 480. Epub 1900 01 01.
Jamburuthugoda VK, Guo D, Wedekind JE, Kim B
Biochemistry.. 2005 August 944 (31):10635-43. Epub 1900 01 01.
Goodman JL, Wang S, Alam S, Ruzicka FJ, Frey PA, Wedekind JE
Biochemistry.. 2004 November 943 (44):13883-91. Epub 1900 01 01.
Xie K, Sowden MP, Dance GS, Torelli AT, Smith HC, Wedekind JE
Proceedings of the National Academy of Sciences of the United States of America.. 2004 May 25101 (21):8114-9. Epub 05/17/2004.
Alam S, Wang SC, Ruzicka FJ, Frey PA, Wedekind JE
Acta crystallographica. Section D, Biological crystallography.. 2004 May 60 (Pt 5):941-4. Epub 04/21/2004.
Song SC, Xie K, Czerwinski M, Spitalnik SL, Wedekind JE
Acta crystallographica. Section D, Biological crystallography.. 2004 April 60 (Pt 4):788-91. Epub 03/23/2004.
Wedekind JE, McKay DB
Biochemistry.. 2003 August 1942 (32):9554-63. Epub 1900 01 01.
Wedekind JE, Dance GS, Sowden MP, Smith HC
Trends in genetics : TIG.. 2003 April 19 (4):207-16. Epub 1900 01 01.
Grum-Tokars V, Milovanovic M, Wedekind JE
Acta crystallographica. Section D, Biological crystallography.. 2003 January 59 (Pt 1):142-5. Epub 12/19/2002.
Wedekind JE, Trame CB, Dorywalska M, Koehl P, Raschke TM, McKee M, FitzGerald D, Collier RJ, McKay DB
Journal of molecular biology.. 2001 December 7314 (4):823-37. Epub 1900 01 01.
Wedekind JE, McKay DB
Methods in enzymology.. 2000 317 :149-68. Epub 1900 01 01.
Wedekind JE, McKay DB
Nature structural biology.. 1999 March 6 (3):261-8. Epub 1900 01 01.
Wedekind JE, McKay DB
Annual review of biophysics and biomolecular structure. 1998 27 :475-502. Epub 1900 01 01.
Babbitt PC, Hasson MS, Wedekind JE, Palmer DR, Barrett WC, Reed GH, Rayment I, Ringe D, Kenyon GL, Gerlt JA
Biochemistry.. 1996 December 2435 (51):16489-501. Epub 1900 01 01.
Reed GH, Poyner RR, Larsen TM, Wedekind JE, Rayment I
Current opinion in structural biology.. 1996 December 6 (6):736-43. Epub 1900 01 01.
Wedekind JE, Frey PA, Rayment I
Biochemistry.. 1996 September 1035 (36):11560-9. Epub 1900 01 01.
Larsen TM, Wedekind JE, Rayment I, Reed GH
Biochemistry.. 1996 April 935 (14):4349-58. Epub 1900 01 01.
Wedekind JE, Frey PA, Rayment I
Biochemistry.. 1995 September 534 (35):11049-61. Epub 1900 01 01.
Ruzicka FJ, Wedekind JE, Kim J, Rayment I, Frey PA
Biochemistry.. 1995 April 2534 (16):5610-7. Epub 1900 01 01.
Wedekind JE, Reed GH, Rayment I
Biochemistry.. 1995 April 434 (13):4325-30. Epub 1900 01 01.
Wedekind JE, Poyner RR, Reed GH, Rayment I
Biochemistry.. 1994 August 933 (31):9333-42. Epub 1900 01 01.
Wedekind JE, Frey PA, Rayment I
Acta crystallographica. Section D, Biological crystallography.. 1994 May 150 (Pt 3):329-31. Epub 1900 01 01.
Books
eLifeSciences (2015)
Chapter: Tails of Three Knotty Switches: How PreQ1 Riboswitch Structures Control Protein Translation
Authors: Belashov I.A., Dutta D., Salim M., Wedekind J.E.
Publisher: John Wiley & Sons, Inc 2015
Chemical Biology of Nucleic Acids (2014)
Chapter: Metal Dependence of Ligand Binding and Heavy-Atom Derivatization of Evolutionarily Distinct PreQ1 Riboswitches
Authors: Joseph E. Wedekind, Joseph A. Liberman, Jermaine L. Jenkins, Mohammad Salim
Publisher: Springer 2014
Metal Ions in Life Sciences: Structural and Catalytic Roles of Metals in RNA (2010)
Chapter: Structural aspects of metal ion binding in small natural and artificial RNA enzymes
Authors: J.E. Wedekind
Publisher: Wiley-Blackwell 2010
In DNA and RNA modification Enzymes: Comparative Structure, Mechanism, Functions (2009)
Chapter: Mechanism of action and structural aspects of ADARS (A-to-I) and APOBEC-related (C-to-U) deaminases
Authors: J.E. Wedekind & P.A Beal
Publisher: Landes BioSciences 2009
RNA and DNA Editing: Molecular Mechanisms and their Integration into Biological (2008)
Chapter: Chemistry, Phylogeny and Structure of the APOBEC Family
Authors: C. McElrevey, J.E. Wedekind
Publisher: Wiley Interscience, New Jersey 2008
Topics in Current Genetics: "Fine-Tuning of RNA Functions by Modification and Ed (2005)
Chapter: Mammalian C to U Editing
Authors: Smith* HC, Wedekind* JE, Xie K, Sowden MP
Publisher: Springer-Verlag, Berlin 2005
The RNA World (1999)
Chapter: Small Ribozymes
Authors: McKay, D.B & Wedekind, J.E.
Publisher: Cold Spring Harbor, Cold Spring Harbor, New York 1999