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Fabeha Fazal, Ph.D.

Fabeha Fazal, Ph.D.

Contact

Office (585) 275-9917
Fax (585) 756-7780
Administrative (585) 275-5948

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About Me

Faculty Appointments

Associate Professor - Department of Pediatrics, Neonatology (SMD)

Credentials

Post-doctoral Training & Residency

Research Assistant Professor, Department of Pediatrics, University of Rochester, Rochester, NY 2003 - 2011

Research Assistant Professor, Department of Physiology and Biophysics, University of Illinois, Chicago, IL 1999 - 2003

Research Associate, Loyola University Medical Center, Maywood, IL 1995 - 1998

Research Associate, Loyola University Medical Center, Maywood, IL; Advisor: Susan Baker, PhD 1992 - 1995

Education

PhD | A.M. University. Biochemistry. 1992

MSc | A.M. University. Biochemistry. 1987

BSc | A.M. University. Chemistry. 1985

Awards

University Gold Medal for standing first in M.S. Examination. 1987

University Gold Medal for standing first in B.S. Examination. 1985

Research

My lab focuses on understanding the pathogenesis of Acute Lung Injury (ALI), a life threatening pulmonary inflammatory condition, which affects over a quarter of million patients in the U.S. with a mortality rate of approximately 40 percent. It is associated with pneumonia, sepsis, and trauma, leadi...
My lab focuses on understanding the pathogenesis of Acute Lung Injury (ALI), a life threatening pulmonary inflammatory condition, which affects over a quarter of million patients in the U.S. with a mortality rate of approximately 40 percent. It is associated with pneumonia, sepsis, and trauma, leading to pulmonary insufficiency and eventually multisystem organ failure. So far, there are no effective therapy targeting the underlying molecular and cellular mechanisms. The two major pathogenic features of ALI involves disruption of pulmonary vascular endothelial barrier and acquisition of a proinflammatory phenotype. The long term goal of my research is to identify novel mechanistic targets and assess the preventive and therapeutic benefit of targeting them against evolving ALI. In our lab we use integration of in vitro and in vivo techniques to dissect the pathways that are critical to endothelial cell (EC) inflammation and permeability. We use multidisciplinary approaches ranging from biochemical, cellular, and molecular biology to in vivo gene delivery and lung physiology.

Publications

Journal Articles

Leonard A, Su PY, Yule DI, Rahman A, Fazal F

Shock.. 2020 August 54 (2):245-255. Epub 1900 01 01.

Leonard A, Millar MW, Slavin SA, Bijli KM, Dionisio Santos, Dean DA, Fazal F, Rahman A

Cellular signalling.. 2019 September 61 :120-129. Epub 05/01/2019.

Leonard A, Grose V, Paton AW, Paton JC, Yule DI, Rahman A, Fazal F

Scientific reports.. 2019 February 149 (1):2096. Epub 02/14/2019.

Leonard A, Rahman A, Fazal F

Cellular signalling.. 2018 April 44 :103-117. Epub 01/11/2018.

Slavin SA, Leonard A, Grose V, Fazal F, Rahman A

American journal of physiology. Lung cellular and molecular physiology.. 2018 March 1314 (3):L388-L396. Epub 10/26/2017.

Jain SV, Kollisch-Singule M, Satalin J, Searles Q, Dombert L, Abdel-Razek O, Yepuri N, Leonard A, Gruessner A, Andrews P, Fazal F, Meng Q, Wang G, Gatto LA, Habashi NM, Nieman GF

Intensive care medicine experimental.. 2017 December 5 (1):25. Epub 05/12/2017.

Barnett RC, Lin X, Barravecchia M, Norman RA, de Mesy Bentley KL, Fazal F, Young JL, Dean DA

Experimental biology and medicine. 2017 July 242 (13):1345-1354. Epub 06/05/2017.

Bijli KM, Fazal F, Slavin SA, Leonard A, Grose V, Alexander WB, Smrcka AV, Rahman A

American journal of physiology. Lung cellular and molecular physiology.. 2016 August 1311 (2):L517-24. Epub 07/01/2016.

Bijli KM, Kanter BG, Minhajuddin M, Leonard A, Xu L, Fazal F, Rahman A

Shock.. 2014 December 42 (6):562-9. Epub 1900 01 01.

Leonard A, Paton AW, El-Quadi M, Paton JC, Fazal F

PloS one.. 2014 9 (10):e110949. Epub 10/30/2014.

Leonard A, Marando C, Rahman A, Fazal F

American journal of physiology. Lung cellular and molecular physiology.. 2013 November 1305 (9):L651-64. Epub 09/13/2013.

Fazal F, Bijli KM, Murrill M, Leonard A, Minhajuddin M, Anwar KN, Finkelstein JN, Watterson DM, Rahman A

PloS one.. 2013 8 (3):e59965. Epub 03/21/2013.

Bijli KM, Fazal F, Rahman A

American journal of respiratory cell and molecular biology.. 2012 November 47 (5):660-8. Epub 07/27/2012.

Rahman A, Fazal F

Proceedings of the American Thoracic Society.. 2011 November 8 (6):497-503. Epub 1900 01 01.

Yang L, Chen G, Mohanty S, Scott G, Fazal F, Rahman A, Begum S, Hynes R, Xu L

Cancer research.. 2011 August 1571 (16):5558-68. Epub 07/01/2011.

Fazal F, Bijli KM, Minhajuddin M, Rein T, Finkelstein JN, Rahman A

The Journal of biological chemistry.. 2009 July 31284 (31):21047-56. Epub 05/29/2009.

Rahman A, Fazal F

Antioxidants & redox signaling.. 2009 April 11 (4):823-39. Epub 1900 01 01.

Minhajuddin M, Bijli KM, Fazal F, Sassano A, Nakayama KI, Hay N, Platanias LC, Rahman A

The Journal of biological chemistry.. 2009 February 13284 (7):4052-61. Epub 12/13/2008.

Bijli KM, Fazal F, Minhajuddin M, Rahman A

The Journal of biological chemistry.. 2008 May 23283 (21):14674-84. Epub 03/24/2008.

Fazal F, Minhajuddin M, Bijli KM, McGrath JL, Rahman A

The Journal of biological chemistry.. 2007 February 9282 (6):3940-50. Epub 12/08/2006.

Bijli KM, Minhajuddin M, Fazal F, O'Reilly MA, Platanias LC, Rahman A

American journal of physiology. Lung cellular and molecular physiology.. 2007 February 292 (2):L396-404. Epub 09/29/2006.

Fazal F, Gu L, Ihnatovych I, Han Y, Hu W, Antic N, Carreira F, Blomquist JF, Hope TJ, Ucker DS, de Lanerolle P

Molecular and cellular biology.. 2005 July 25 (14):6259-66. Epub 1900 01 01.

Minhajuddin M, Fazal F, Bijli KM, Amin MR, Rahman A

The Journal of immunology : official journal of the American Association of Immunologists.. 2005 May 1174 (9):5823-9. Epub 1900 01 01.

Anwar KN, Fazal F, Malik AB, Rahman A

The Journal of immunology : official journal of the American Association of Immunologists.. 2004 December 1173 (11):6965-72. Epub 1900 01 01.

Nobe H, Nobe K, Fazal F, De Lanerolle P, Paul RJ

American journal of physiology. Cell physiology.. 2003 March 284 (3):C599-606. Epub 10/03/2002.

Adami C, Pooley J, Glomb J, Stecker E, Fazal F, Fleming JO, Baker SC

Virology.. 1995 June 1209 (2):337-46. Epub 1900 01 01.

Books

Glimpses in Plant Research XI: Medicinal Plants; New Vistas of Research [Part 2] (1993)

Chapter: Strand scission in DNA induced by dietary flavonoids: Role of Cu (II) and oxygen free radicals.

Authors: Rahman A, Fazal F, Hadi SM

Publisher: Today and Tomorrow's Printers and Publishers, New Delhi, India 1993