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Roman A. Eliseev, M.D., Ph.D.

Roman A. Eliseev, M.D., Ph.D.

Contact

Office (585) 276-3396
Fax (585) 275-1121
Administrative (585) 273-5635

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Visit my lab website to learn more about my research, collaborators, latest news, etc.

About Me

Faculty Appointments

Associate Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD)

Associate Professor - Department of Pathology and Laboratory Medicine (SMD) - Joint

Associate Professor - Department of Pharmacology and Physiology (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Center for Musculoskeletal Research 2003 - 2005

Education

PhD | Univ Rochester Sch Med/Dent. Biochemistry. 2002

MS | University of Rochester School of Medicine. 1999

MD | Russia-Russian State Medical Univ. Medicine. 1995

Undergraduate/Medical | Russian State Medical University (RSMU). 0

Graduate | University of Rochester School of Medicine. 0

Awards

CTSI KL2 Career Award. 2009 - 2011

Wilmot Cancer Research Fellowship. 2004 - 2007

NIH Travel Scholarship. 2002

Graduate Student Society Research Award. 2001

Young Investigator Award. 2000

Young Investigator Award. 1998

Moscow Mayor's Honorary Scholarship. 1993 - 1995

Freshman Competitive Scholarship. 1987 - 1988

Research

The main goal of our research efforts is to understand how cell metabolism determines cell fate and how it can be manipulated for the purposes of prevention and therapies. Mitochondria are "powerhouses" of the cell and also important components of cell signaling. In undifferentiated stem cells mitoc...
The main goal of our research efforts is to understand how cell metabolism determines cell fate and how it can be manipulated for the purposes of prevention and therapies. Mitochondria are "powerhouses" of the cell and also important components of cell signaling. In undifferentiated stem cells mitochondria are inactive but become activated during the process of differentiation. We focus on the mechanism of this metabolic switch in mesenchymal stem cells (MSC), common precursors of osteoblasts, chondrocytes, and adipocytes, and how this mechanism is disrupted in aging and in various diseases.

Similarly to undifferentiated stem cells, many cancer cells show preference for glycolytic over mitochondrial metabolism even in the presence of adequate oxygen, a phenomenon known as the Warburg effect. We study how cell metabolism regulates sensitivity of osteosarcoma to treatments. Our data indicate that the Warburg effect is especially pronounced in osteosarcoma cancer stem cells (CSC), and reversal of this effect makes CSCs less viable and more sensitive to radiation.

Patents

Use of Cyclophilin D Inhibitors to Treat or Prevent Bone Disorders

Issue date: December 05, 2017

Patent #: 9,833,467

Country: United States

Inventors: Roman A Eliseev

Publications

Journal Articles

Sautchuk R, Martinez J, Catheline SE, Eliseev RA

Bone.. 2024 September 18 :117258. Epub 09/18/2024.

Yu C, Sautchuk R, Martinez J, Eliseev RA

The Journal of biological chemistry.. 2023 December 299 (12):105458. Epub 11/08/2023.

Catheline SE, Kaiser E, Eliseev RA

Current osteoporosis reports.. 2023 October 21 (5):540-551. Epub 08/05/2023.

Quarato ER, Salama NA, Li AJ, Smith CO, Zhang J, Kawano Y, McArthur M, Liesveld JL, Becker MW, Elliott MR, Eliseev RA, Calvi LM

Cell death & disease.. 2023 July 1414 (7):428. Epub 07/14/2023.

Kawano H, Kawano Y, Yu C, LaMere MW, McArthur MJ, Becker MW, Ballinger SW, Gojo S, Eliseev RA, Calvi LM

Cells.. 2023 May 2512 (11)Epub 05/25/2023.

Sautchuk R, Yu C, McArthur M, Massie C, Brookes PS, Porter GA, Awad H, Eliseev RA

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2023 April 38 (4):522-540. Epub 03/09/2023.

Tow BD, Deb A, Neupane S, Patel S, Reed M, Loper AB, Eliseev RA, Knollmann BC, Györke S, Liu B

Cardiovascular research.. 2022 October 21118 (13):2819-2832. Epub 1900 01 01.

Sautchuk R, Eliseev RA

Bone reports.. 2022 June 16 :101594. Epub 05/27/2022.

Sautchuk R, Kalicharan BH, Escalera-Rivera K, Jonason JH, Porter GA, Awad HA, Eliseev RA

eLife.. 2022 May 3011 Epub 05/30/2022.

Hollenberg AM, Huber A, Smith CO, Eliseev RA

Scientific reports.. 2021 September 2711 (1):19114. Epub 09/27/2021.

Hollenberg AM, Maqsoodi N, Phan A, Huber A, Jubril A, Baldwin AL, Yokogawa N, Eliseev RA, Mesfin A

The spine journal : official journal of the North American Spine Society.. 2021 July 21 (7):1205-1216. Epub 03/05/2021.

Smith CO, Eliseev RA

Stem cells and development.. 2021 February 30 (3):149-162. Epub 01/11/2021.

Hollenberg AM, Smith CO, Shum LC, Awad H, Eliseev RA

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2020 December 35 (12):2432-2443. Epub 09/19/2020.

Shares BH, Smith CO, Sheu TJ, Sautchuk R, Schilling K, Shum LC, Paine A, Huber A, Gira E, Brown E, Awad H, Eliseev RA

Bone.. 2020 August 137 :115391. Epub 04/28/2020.

Shum LC, Hollenberg AM, Baldwin AL, Kalicharan BH, Maqsoodi N, Rubery PT, Mesfin A, Eliseev RA

PloS one.. 2020 15 (11):e0241998. Epub 11/09/2020.

Shares BH, Busch M, White N, Shum L, Eliseev RA

The Journal of biological chemistry.. 2018 October 12293 (41):16019-16027. Epub 08/27/2018.

Feigenson M, Eliseev RA, Jonason JH, Mills BN, O'Keefe RJ

Journal of cellular biochemistry.. 2017 December 118 (12):4383-4393. Epub 05/31/2017.

Shum LC, White NS, Mills BN, de Mesy Bentley KL, Eliseev RA

Stem cells and development.. 2016 January 1525 (2):114-22. Epub 12/10/2015.

Shum LC, White NS, Nadtochiy SM, Bentley KL, Brookes PS, Jonason JH, Eliseev RA

PloS one.. 2016 11 (5):e0155709. Epub 05/16/2016.

Beutner G, Eliseev RA, Porter GA

PloS one.. 2014 9 (11):e113330. Epub 11/26/2014.

Giang AH, Raymond T, Brookes P, Demesy-Bentley K, Schwarz E, O'Keefe R, Eliseev R

The Journal of biological chemistry.. 2013 November 15288 (46):33303-11. Epub 10/07/2013.

Zuch D, Giang AH, Shapovalov Y, Schwarz E, Rosier R, O'Keefe R, Eliseev RA

Journal of cellular biochemistry.. 2012 April 113 (4):1282-91. Epub 1900 01 01.

Shapovalov Y, Hoffman D, Zuch D, de Mesy Bentley KL, Eliseev RA

The Journal of biological chemistry.. 2011 June 24286 (25):22331-8. Epub 05/02/2011.

Shapovalov Y, Benavidez D, Zuch D, Eliseev RA

International journal of cancer.. 2010 July 1127 (1):67-76. Epub 1900 01 01.

Eliseev RA, Malecki J, Lester T, Zhang Y, Humphrey J, Gunter TE

The Journal of biological chemistry.. 2009 April 10284 (15):9692-9. Epub 02/19/2009.

Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH

Oncogene.. 2008 June 527 (25):3605-14. Epub 01/28/2008.

Eliseev RA, Filippov G, Velos J, VanWinkle B, Goldman A, Rosier RN, Gunter TE

Neurobiology of aging.. 2007 October 28 (10):1532-42. Epub 07/31/2006.

Gunter KK, Aschner M, Miller LM, Eliseev R, Salter J, Anderson K, Gunter TE

Neurobiology of aging.. 2006 December 27 (12):1816-26. Epub 11/14/2005.

Eliseev RA, Schwarz EM, Zuscik MJ, O'Keefe RJ, Drissi H, Rosier RN

Experimental cell research.. 2006 January 1312 (1):40-50. Epub 11/02/2005.

Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN

Journal of cellular biochemistry.. 2005 December 1596 (6):1262-73. Epub 1900 01 01.

Gunter KK, Aschner M, Miller LM, Eliseev R, Salter J, Anderson K, Hammond S, Gunter TE

Free radical biology & medicine.. 2005 July 1539 (2):164-81. Epub 03/31/2005.

Eliseev RA, Vanwinkle B, Rosier RN, Gunter TE

The Journal of biological chemistry.. 2004 November 5279 (45):46748-54. Epub 08/23/2004.

Gunter TE, Yule DI, Gunter KK, Eliseev RA, Salter JD

FEBS letters.. 2004 June 1567 (1):96-102. Epub 1900 01 01.

Gunter TE, Miller LM, Gavin CE, Eliseev R, Salter J, Buntinas L, Alexandrov A, Hammond S, Gunter KK

Journal of neurochemistry.. 2004 January 88 (2):266-80. Epub 1900 01 01.

High-Yield Expression and Purification of p18 Form of Bax as an MBP-Fusion Protein.

Eliseev, RA, Alexandrov, AA, and TE Gunter.

Prot Expr Purif. 2004; : 206-209.

Eliseev RA, Gunter KK, Gunter TE

Experimental cell research.. 2003 October 1289 (2):275-81. Epub 1900 01 01.

Eliseev RA, Salter JD, Gunter KK, Gunter TE

Biochimica et biophysica acta.. 2003 April 181604 (1):1-5. Epub 1900 01 01.

Gunter KK, Miller LM, Aschner M, Eliseev R, Depuis D, Gavin CE, Gunte TE

Neurotoxicology.. 2002 July 23 (2):127-46. Epub 1900 01 01.

Eliseev RA, Gunter KK, Gunter TE

Mitochondrion.. 2002 February 1 (4):361-70. Epub 1900 01 01.

Pateder DB, Eliseev RA, O'Keefe RJ, Schwarz EM, Okunieff P, Constine LS, Puzas JE, Rosier RN

Radiation research.. 2001 June 155 (6):847-57. Epub 1900 01 01.

Radiation injury to growth plate/epiphyseal chondrocytes: molecular mechanisms

Constine, LS, Pateder, D, O'Keefe, R, Hicks, D, Eliseev, R, Williams, J, Puzas, E, and R Rosier.

Intl J Rad Onc Biol Phys. 2000; : 284.

Gunter TE, Buntinas L, Sparagna G, Eliseev R, Gunter K

Cell calcium.. 2000 28 (5-6):285-96. Epub 1900 01 01.

The Rapid Mode (RaM) of Mitochondrial Calcium Transport

Buntinas, L, Eliseev, R, Gunter, KK, and TE Gunter,.

Biophys J,. 1998; : A382.

Influence of Some Steroid Hormones on Calcium Transport and Oxidative Metabolism in Isolated Mitochondria

Lukianova, LD, Eliseev, RA, Makarenko, T, and AI Matiushin.

Bull Exp Biol Med. 1994; : 1307-1310.