Edward Brown, Ph.D.
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Edward Brown, Ph.D.
About Me
Faculty Appointments
Associate Professor - Department of Neuroscience (SMD) - Joint
Credentials
Post-doctoral Training & Residency
Post-Doctoral Fellow, Department of Radiation Oncology, Harvard Medical School / Massachusetts General Hospital. Laboratory of Dr. Rakesh K. Jain. 1999 - 2001
Education
PhD | Cornell University. Physics. 1999
MS | Cornell University. Physics. 1995
BS | Wake Forest University. Physics. 1992
Awards
NIH Director's New Innovator Award. 2009 - 2014
Pew Scholar in the Biomedical Sciences Award. 2007 - 2011
Era of Hope Scholar Award. 2005 - 2010
AACR-Aflac Scholars in Cancer Research Award. 2000
Phi Beta Kappa. 1992
Speas Award for Excellence in Physics. 1992
Reynolds Scholarship (full room, full board, full tuition, stipend). 1984 - 1988
Research
Patents
Methods of Treating Cancer Using The Calcitonin-Gene Related Peptide ("CGRP") Receptor Antagonist CGRP8-37
Issue date: March 12, 2013
Patent #: 8,394,767
Country: United States
Inventors: Edward Brown III, Ian Dickerson
System and Method for Measuring the Ratio of Forward-Propagating to Back-Propagating Second Harmonic-Generation Signal, and Applications Thereof
Issue date: August 19, 2014
Patent #: 8,812,085
Country: United States
Inventors: Edward Brown III, Xiaoxing Han
Method and Apparatus to Diagnose the Metatstatic or Progressive Potential of Cancer, Fibrosis and other Diseases
Issue date: September 08, 2020
Patent #: 10,765,376
Country: United States
Inventors: Edward Brown III, Kathleen Burke, Robert Matthew Kottmann, Seth W Perry, Jesse W Sharpe, Patricia Janet Sime
Publications
Journal Articles
Joshi IM, Mansouri M, Ahmed A, De Silva D, Simon RA, Esmaili P, Desa DE, Elias TM, Brown EB, Abhyankar VV
Advanced functional materials.. 2024 March 2534 (13)Epub 12/17/2023.
Joshi IM, Mansouri M, Ahmed A, Simon RA, Bambizi PE, Desa DE, Elias TM, Brown EB, Abhyankar VV
bioRxiv : the preprint server for biology.. 2023 July 10 Epub 07/10/2023.
Elias TM, Brown EB, Brown EB
Journal of biomedical optics.. 2023 July 28 (7):076502. Epub 07/21/2023.
Schilling K, Zhai Y, Zhou Z, Zhou B, Brown E, Zhang X
eLife.. 2022 November 311 Epub 11/03/2022.
Dunn KJ, Elias TM, Brown EB, Berger AJ
Biomedical optics express.. 2022 August 113 (8):4236-4246. Epub 07/19/2022.
Martin JD, Lanning RM, Chauhan VP, Martin MR, Mousa AS, Kamoun WS, Han HS, Lee H, Stylianopoulos T, Bawendi MG, Duda DG, Brown EB, Padera TP, Fukumura D, Jain RK
Clinical cancer research : an official journal of the American Association for Cancer Research.. 2022 July 1528 (14):3076-3090. Epub 1900 01 01.
Desa DE, Wu W, Brown RM, Brown EB, Hill RL, Turner BM, Brown EB
Cancers.. 2022 February 914 (4)Epub 02/09/2022.
Schilling K, Brown E, Zhang X
Bone.. 2022 January 154 :116257. Epub 11/13/2021.
Zhai Y, Schilling K, Wang T, El Khatib M, Vinogradov S, Brown EB, Zhang X
Biomaterials.. 2021 September 276 :121041. Epub 07/26/2021.
Desa DE, Strawderman RL, Wu W, Hill RL, Smid M, Martens JWM, Turner BM, Brown EB
BMC cancer.. 2020 December 1020 (1):1217. Epub 12/10/2020.
Shares BH, Smith CO, Sheu TJ, Sautchuk R, Schilling K, Shum LC, Paine A, Huber A, Gira E, Brown E, Awad H, Eliseev RA
Bone.. 2020 August 137 :115391. Epub 04/28/2020.
Stowell RD, Sipe GO, Dawes RP, Batchelor HN, Lordy KA, Whitelaw BS, Stoessel MB, Bidlack JM, Brown E, Sur M, Majewska AK
Nature neuroscience.. 2020 January 23 (1):152. Epub 1900 01 01.
Dawes RP, Burke KA, Byun DK, Xu Z, Stastka P, Chan L, Brown EB, Madden KS
Breast cancer : basic and clinical research.. 2020 14 :1178223420931511. Epub 06/17/2020.
Stowell RD, Sipe GO, Dawes RP, Batchelor HN, Lordy KA, Whitelaw BS, Stoessel MB, Bidlack JM, Brown E, Sur M, Majewska AK
Nature neuroscience.. 2019 November 22 (11):1782-1792. Epub 10/21/2019.
Schilling K, El Khatib M, Plunkett S, Xue J, Xia Y, Vinogradov SA, Brown E, Zhang X
ACS applied materials & interfaces.. 2019 September 1811 (37):33548-33558. Epub 09/04/2019.
Desa DE, Bhanote M, Hill RL, Majeski JB, Buscaglia B, D'Aguiar M, Strawderman R, Hicks DG, Turner BM, Brown EB
Journal of biomedical optics.. 2019 August 24 (8):1-9. Epub 1900 01 01.
Yu D, Brown EB, Huxlin KR, Knox WH
Biomedical optics express.. 2019 February 110 (2):855-867. Epub 01/24/2019.
Pan XS, Li J, Brown EB, Kuo CK
Philosophical transactions of the Royal Society of London. Series B, Biological sciences.. 2018 September 24373 (1759)Epub 09/24/2018.
Paquette ST, Dawes RP, Sundar IK, Rahman I, Brown EB, White PM
Scientific reports.. 2018 April 108 (1):5746. Epub 04/10/2018.
Ramirez G, Proctor AR, Jung KW, Wu TT, Han S, Adams RR, Ren J, Byun DK, Madden KS, Brown EB, Foster TH, Farzam P, Durduran T, Choe R
Biomedical optics express.. 2016 September 17 (9):3610-3630. Epub 08/24/2016.
Herr MM, Mohile NA, Barr PM, van Wijngaarden E, Brown EB, Rich DQ
Clinical lymphoma, myeloma & leukemia.. 2016 September 16 (9):e123-e127. Epub 06/08/2016.
Herr MM, Mohile NA, van Wijngaarden E, Brown EB, Rich DQ
Journal of neuro-oncology.. 2016 August 129 (1):179-87. Epub 06/11/2016.
Haynes-Gimore N, Banach M, Brown E, Dawes R, Edholm ES, Kim M, Robert J
Developmental biology.. 2015 December 15408 (2):205-12. Epub 01/17/2015.
Van Hove AH, Burke K, Antonienko E, Brown E, Benoit DS
Journal of controlled release : official journal of the Controlled Release Society.. 2015 November 10217 :191-201. Epub 09/11/2015.
Van Hove AH, Antonienko E, Burke K, Brown E, Benoit DS
Advanced healthcare materials.. 2015 September 164 (13):2002-11. Epub 07/07/2015.
Huang C, Ness VP, Yang X, Chen H, Luo J, Brown EB, Zhang X
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2015 July 30 (7):1217-30. Epub 1900 01 01.
Kottmann RM, Sharp J, Owens K, Salzman P, Xiao GQ, Phipps RP, Sime PJ, Brown EB, Perry SW
Respiratory research.. 2015 May 2716 (1):61. Epub 05/27/2015.
Burke KA, Dawes RP, Cheema MK, Van Hove A, Benoit DS, Perry SW, Brown E
Journal of biomedical optics.. 2015 May 20 (5):051024. Epub 1900 01 01.
Bouta EM, Li J, Ju Y, Brown EB, Ritchlin CT, Xing L, Schwarz EM
Seminars in cell & developmental biology.. 2015 February 38 :90-7. Epub 01/15/2015.
Sullivan KD, Majewska AK, Brown EB
Cold Spring Harbor protocols.. 2015 January 52015 (1):pdb.top083519. Epub 01/05/2015.
Burke K, Brown E
Intravital.. 2014 December 3 (3):e984509. Epub 01/06/2015.
Shapovalov Y, Zettel M, Spielman SC, Amico-Ruvio SA, Kelly EA, Sipe GO, Dickerson IM, Majewska AK, Brown EB
BMC cancer.. 2014 August 1614 :598. Epub 08/16/2014.
Bouta EM, Wood RW, Brown EB, Rahimi H, Ritchlin CT, Schwarz EM
The Journal of physiology.. 2014 March 15592 (6):1213-23. Epub 01/13/2014.
Szpunar MJ, Burke KA, Dawes RP, Brown EB, Madden KS
Cancer prevention research.. 2013 December 6 (12):1262-72. Epub 1900 01 01.
Perry SW, Schueckler JM, Burke K, Arcuri GL, Brown EB
BMC cancer.. 2013 September 513 :411. Epub 09/05/2013.
Arendt O, Schwaller B, Brown EB, Eilers J, Schmidt H
The Journal of physiology.. 2013 August 15591 (16):3887-99. Epub 06/03/2013.
Burke RM, Madden KS, Perry SW, Zettel ML, Brown EB
Journal of biomedical optics.. 2013 August 18 (8):86003. Epub 1900 01 01.
Chen T, Hilton MJ, Brown EB, Zuscik MJ, Awad HA
Biotechnology and bioengineering.. 2013 May 110 (5):1476-86. Epub 12/27/2012.
Madden KS, Zettel ML, Majewska AK, Brown EB
Cold Spring Harbor protocols.. 2013 March 12013 (3)Epub 03/01/2013.
Madden KS, Zettel ML, Majewska AK, Brown EB
Cold Spring Harbor protocols.. 2013 March 12013 (3)Epub 03/01/2013.
Madden KS, Szpunar MJ, Brown EB
Brain, behavior, and immunity.. 2013 March 30 Suppl (Suppl):S135-41. Epub 05/17/2012.
Burke K, Tang P, Brown E
Journal of biomedical optics.. 2013 March 18 (3):31106. Epub 1900 01 01.
Perry SW, Burke RM, Brown EB
Annals of biomedical engineering.. 2012 February 40 (2):277-91. Epub 01/19/2012.
Madden KS, Szpunar MJ, Brown EB
Breast cancer research and treatment.. 2011 December 130 (3):747-58. Epub 01/14/2011.
Bouta EM, Wood RW, Perry SW, Brown EB, Ritchlin CT, Xing L, Schwarz EM
Annals of the New York Academy of Sciences.. 2011 December 1240 :47-52. Epub 1900 01 01.
Sullivan KD, Brown EB
Physical review. E, Statistical, nonlinear, and soft matter physics.. 2011 May 83 (5 Pt 1):051916. Epub 05/16/2011.
Perry SW, Norman JP, Barbieri J, Brown EB, Gelbard HA
BioTechniques.. 2011 February 50 (2):98-115. Epub 1900 01 01.
Diffusion and multi-photon fluorescence recovery after photobleaching in bounded systems
Sullivan, K.;Brown, E.
Physical review E. In Press. 2011; .
Mitochondrial membrane potential probes and the proton gradient: a practical usage guide
Perry, S.; Norman, J.; Barbieri, J.; Brown, E.; Gelbard, H.
BioTechniques. In Press. 2011; .
Kozai TD, Marzullo TC, Hooi F, Langhals NB, Majewska AK, Brown EB, Kipke DR
Journal of neural engineering.. 2010 August 7 (4):046011. Epub 07/19/2010.
Han X, Brown E
Optics express.. 2010 May 1018 (10):10538-50. Epub 1900 01 01.
Sullivan KD, Brown EB
Journal of visualized experiments : JoVE.. 2010 February 26 (36)Epub 02/26/2010.
Thermally activated diffusion in reversibly associating polymers
Li, J.; Sullivan, K.; Brown, E.;Anthamatten, M.
Soft matter. 2010; 6: 235-238.
Measuring Diffusion Coefficients via Two-Photon Fluorescence Recovery After Photobleaching
Sullivan, K.;Brown, E.
Journal of visualized experiments. 2010; 36.
Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK
Biophysical journal.. 2009 July 897 (1):330-6. Epub 1900 01 01.
Sullivan KD, Sipprell WH, Brown EB, Brown EB
Biophysical journal.. 2009 June 1796 (12):5082-94. Epub 1900 01 01.
Han X, Burke RM, Zettel ML, Tang P, Brown EB
Optics express.. 2008 February 416 (3):1846-59. Epub 1900 01 01.
Schmidt H, Arendt O, Brown EB, Schwaller B, Eilers J
Journal of neurochemistry.. 2007 February 100 (3):727-35. Epub 1900 01 01.
Tyrrell JA, Mahadevan V, Tong RT, Brown EB, Jain RK, Roysam B
Microvascular research.. 2005 November 70 (3):165-78. Epub 10/18/2005.
Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK
Nature medicine.. 2005 June 11 (6):678-82. Epub 05/08/2005.
Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK
Cancer research.. 2004 September 164 (17):5920-4. Epub 1900 01 01.
Brown EB, Boucher Y, Nasser S, Jain RK
Microvascular research.. 2004 May 67 (3):231-6. Epub 1900 01 01.
Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK
Nature.. 2004 March 18428 (6980):328-32. Epub 1900 01 01.
Alexandrakis G, Brown EB, Tong RT, McKee TD, Campbell RB, Boucher Y, Jain RK
Nature medicine.. 2004 February 10 (2):203-7. Epub 01/11/2004.
Znati CA, Rosenstein M, McKee TD, Brown E, Turner D, Bloomer WD, Watkins S, Jain RK, Boucher Y
Clinical cancer research : an official journal of the American Association for Cancer Research.. 2003 November 159 (15):5508-13. Epub 1900 01 01.
Abdul-Karim MA, Al-Kofahi K, Brown EB, Jain RK, Roysam B
Microvascular research.. 2003 September 66 (2):113-25. Epub 1900 01 01.
Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK
Nature medicine.. 2003 June 9 (6):796-800. Epub 05/18/2003.
Schmidt H, Brown EB, Schwaller B, Eilers J
Biophysical journal.. 2003 April 84 (4):2599-608. Epub 1900 01 01.
Wei X, Henke VG, Strübing C, Brown EB, Clapham DE
Biophysical journal.. 2003 February 84 (2 Pt 1):1317-27. Epub 1900 01 01.
Campbell RB, Fukumura D, Brown EB, Mazzola LM, Izumi Y, Jain RK, Torchilin VP, Munn LL
Cancer research.. 2002 December 162 (23):6831-6. Epub 1900 01 01.
Migliorini C, Qian Y, Chen H, Brown EB, Jain RK, Munn LL
Biophysical journal.. 2002 October 83 (4):1834-41. Epub 1900 01 01.
Ramanujan S, Pluen A, McKee TD, Brown EB, Boucher Y, Jain RK
Biophysical journal.. 2002 September 83 (3):1650-60. Epub 1900 01 01.
Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK
Science.. 2002 June 7296 (5574):1883-6. Epub 04/25/2002.
Brown EB, Campbell RB, Tsuzuki Y, Xu L, Carmeliet P, Fukumura D, Jain RK
Nature medicine.. 2001 July 7 (7):864-8. Epub 1900 01 01.
Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK
Proceedings of the National Academy of Sciences of the United States of America.. 2001 April 1098 (8):4628-33. Epub 03/27/2001.
Majewska A, Brown E, Ross J, Yuste R
The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2000 March 120 (5):1722-34. Epub 1900 01 01.
Brown EB, Wu ES, Zipfel W, Webb WW
Biophysical journal.. 1999 November 77 (5):2837-49. Epub 1900 01 01.
Brown EB, Shear JB, Adams SR, Tsien RY, Webb WW
Biophysical journal.. 1999 January 76 (1 Pt 1):489-99. Epub 1900 01 01.
Brown EB, Webb WW
Methods in enzymology.. 1998 291 :356-80. Epub 1900 01 01.
Shear JB, Brown EB, Webb WW
Analytical chemistry.. 1996 May 1568 (10):1778-83. Epub 1900 01 01.
Books
Imaging: A Laboratory Manual (2011)
Chapter: Single and Multiphoton Fluorescence Recovery After Photobleaching
Authors: Sullivan K, Majewska A, Brown E
Publisher: Cold Spring Harbor Laboratory Press, Cold Spring Harbor 2011
Imaging in Neuroscience: A Laboratory Manual (2011)
Chapter: Imaging Tumors in the Brain
Authors: Madden K, Zettel M, Majewska A, Brown E
Publisher: Cold Spring Harbor Laboratory Press, In Press, Cold Spring Harbor 2011
Second Harmonic Generation Imaging (2011)
Chapter: Second Harmonic Imaging of Tumors
Authors: Han X, Perry S, Brown E
Publisher: Taylor and Francis Press, In Preparation 2011
Handbook of Biological Nonlinear Optical Microscopy (2008)
Chapter: Photobleaching and Recovery with Nonlinear Microscopy
Authors: Brown E, Majewska A, Jain RK
Publisher: Oxford University Press, Oxford 2008
Handbook of Biological Nonlinear Optical Microscopy (2008)
Chapter: Applications of Nonlinear Intravital Microscopy in Tumor Biology
Authors: Jain RK, Booth M, Padera T, Munn L, Fukumura D, Brown E
Publisher: Oxford University Press, Oxford 2008
Textbook of in vivo Imaging of Vertebrates (2007)
Chapter: Optical Microscopy in Small Animal Research
Authors: Jain RK, Fukumura D, Munn L, Brown E
Publisher: Wiley & Sons, London 2007
Textbook of in vivo Imaging of Vertebrates (2007)
Chapter: Tumor Angiogenesis and Blood Flow
Authors: Jain RK, Fukumura D, Munn L, Brown E
Publisher: Wiley & Sons, London 2007
Imaging in Neuroscience and Development: A Laboratory Manual (2005)
Chapter: FRAP and Multiphoton FRAP
Authors: Brown E, Majewska A, Jain RK
Publisher: Cold Spring Harbor Laboratory Press, Cold Spring Harbor 2005
Imaging in Neuroscience and Development: A Laboratory Manual (2005)
Chapter: A Practical Guide to in vivo Imaging of Tumors
Authors: Brown E, Munn L, Fukumura D, Jain RK
Publisher: Cold Spring Harbor Laboratory Press, Cold Spring Harbor 2005
Live Cell Imaging: A Laboratory Manual (2004)
Chapter: Intravital Microscopy of Normal and Diseased Tissue in the Mouse
Authors: Jain RK, Brown E, Munn L, Fukumura D
Publisher: Cold Spring Harbor Laboratory Press, Cold Spring Harbor 2004
Methods of Enzymology (1998)
Chapter: Two-Photon Activation of Caged Calcium with Submicron, Submillisecond Resolution
Authors: Brown E, Webb W
Publisher: Academic Press, San Diego 1998