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Paul J. Kammermeier, Ph.D.

Paul J. Kammermeier, Ph.D.

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About Me

Faculty Appointments

Associate Professor - Department of Pharmacology and Physiology (SMD)

Credentials

Post-doctoral Training & Residency

Research Fellow: National Institutes of Health (NIAAA), Rockville, MD. Advisor: Stephen R. Ikeda, M.D., Ph.D. 2002 - 2002

Post-Doctoral Associate: Guthrie Research Institute, Sayre, PA. Advisor: Stephen R. Ikeda, M.D., Ph.D. 1998 - 2002

Post-Doctoral Associate: University of Florida, Department of Physiology, Gainesville, FL. Principal Advisor: Philip Posner, Ph.D. 1997 - 1998

Education

PhD | Case Western Reserve Univ. Neuroscience. 1997

BS | Univ of Pittsburgh. Neuroscience. 1990

Research

My research interests center around G protein-coupled receptor function, particularly metabotropic glutamate receptors (mGluRs), and ion channel modulation in neurons. Naturally, this work has led me toward an interest in heterotrimeric G proteins, G protein-coupled receptors and factors that modula...
My research interests center around G protein-coupled receptor function, particularly metabotropic glutamate receptors (mGluRs), and ion channel modulation in neurons. Naturally, this work has led me toward an interest in heterotrimeric G proteins, G protein-coupled receptors and factors that modulate G protein signaling, such as the Regulators of G protein Signaling (RGS) proteins (see Kammermeier and Ikeda, 1999, Neuron 22:819). I have also become interested in the Homer family of scaffolding proteins, which I have shown to be important in the function and sub-cellular localization of metabotropic glutamate receptors (Kammermeier et al., 2000, Journal of Neuroscience 220:7238; Kammermeier, 2005, BMC Neuroscience 7:1). In the long term, my goal is to understand the mechanisms of regulation, localization and signaling that impart specificity to the various mGluRs, and how regulation of mGluR signaling alters synaptic strength in the nervous system.
In my laboratory, two basic experimental approaches are used. The first utilizes primary cultures of isolated SCG neurons for electrophysiological, molecular biological, immunofluorescence and RT-PCR experiments. The main technique used in this system is to examine the well-characterized ion channel modulatory pathways using patch-clamp electro-physiology as an assay for G protein coupled receptor activity. The neurons can be made to express various heterologous proteins (including mGluRs) via intranuclear injection of cDNA. I have recently used this system to examine mGluR-G protein coupling specificity, mGluR desensitization and the regulation of mGluR signaling and trafficking by various associated proteins.

The second approach is to use native neuronal cells. Currently, we are working with both primary isolated ON Bipolar cells from the rat retina and with rat hippocampal neurons to examine G protein coupling of mGluR6 and the effects of Homer protein regulation of mGluR5 at synapses, respectively. These systems allow us to ask questions about the physiological relevance in parallel with the more tractable, highly amenable SCG system described above.

Finally, we are beginning to incorporate other fluorescence-based techniques such as total internal reflection fluorescence (TIRF) microscopy (Kammermeier, 2005, BMC Neuroscience 7:1) to examine protein distribution in or very near the cell membrane.

Publications

Journal Articles

Scott MB, Kammermeier PJ

Pharmaceuticals.. 2024 September 1917 (9)Epub 09/19/2024.

Chen X, Bell NA, Coffman BL, Rabino AA, Garcia-Mata R, Kammermeier PJ, Yule DI, Axelrod D, Smrcka AV, Giovannucci DR, Anantharam A

Molecular biology of the cell.. 2024 July 135 (7):ar92. Epub 05/17/2024.

McCullock TW, Cardani LP, Kammermeier PJ

Molecular pharmacology.. 2024 January 10105 (2):104-115. Epub 01/10/2024.

Chen X, Bell NA, Coffman BL, Rabino AA, Garcia-Mata R, Kammermeier PJ, Yule DI, Axelrod D, Smrcka AV, Giovannucci DR, Anantharam A

bioRxiv : the preprint server for biology.. 2024 January 3 Epub 01/03/2024.

McCullock TW, Cardani LP, Kammermeier PJ

bioRxiv : the preprint server for biology.. 2023 July 28 Epub 07/28/2023.

Morales A, Mohan R, Chen X, Coffman BL, Bendahmane M, Watch L, West JL, Bakshi S, Traynor JR, Giovannucci DR, Kammermeier PJ, Axelrod D, Currie KPM, Smrcka AV, Anantharam A

The Journal of general physiology.. 2023 February 6155 (2)Epub 12/20/2022.

McCullock TW, Kammermeier PJ

Neuropharmacology.. 2021 November 1199 :108801. Epub 09/20/2021.

Singh A, Van Slyke AL, Sirenko M, Song A, Kammermeier PJ, Zipfel WR

Scientific reports.. 2020 September 1010 (1):14866. Epub 09/10/2020.

McCullock TW, MacLean DM, Kammermeier PJ

PloS one.. 2020 15 (2):e0219886. Epub 02/05/2020.

McCullock TW, Kammermeier PJ

Pharmacology research & perspectives.. 2019 June 7 (3):e00471. Epub 05/03/2019.

Scott MB, Kammermeier PJ

Channels.. 2017 November 211 (6):555-573. Epub 09/21/2017.

Brenowitz S, Duguid I, Kammermeier PJ

Cold Spring Harbor protocols.. 2017 July 52017 (7):pdb.top092288. Epub 07/05/2017.

Hu JH, Worley PF, Kammermeier PJ

The Journal of pharmacology and experimental therapeutics.. 2017 April 361 (1):122-129. Epub 02/08/2017.

Kammermeier PJ

BMC neuroscience.. 2015 March 2416 :17. Epub 03/24/2015.

Sevastyanova TN, Kammermeier PJ

Molecular pharmacology.. 2014 November 86 (5):492-504. Epub 08/11/2014.

Beqollari D, Kammermeier PJ

Neuropharmacology.. 2013 March 66 :302-10. Epub 05/30/2012.

Kammermeier PJ

Molecular pharmacology.. 2012 September 82 (3):438-47. Epub 05/31/2012.

Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, Worley PF

Nature neuroscience.. 2012 June 15 (6):836-44. Epub 1900 01 01.

Kammermeier PJ

BMC pharmacology.. 2012 May 2912 :6. Epub 05/29/2012.

Beqollari D, Kammermeier PJ

Journal of neurophysiology.. 2010 July 104 (1):439-48. Epub 05/12/2010.

Kammermeier PJ

European journal of pharmacology.. 2010 February 10627 (1-3):63-8. Epub 10/30/2009.

Beqollari D, Betzenhauser MJ, Kammermeier PJ

Molecular pharmacology.. 2009 November 76 (5):992-7. Epub 08/07/2009.

Cao Y, Masuho I, Okawa H, Xie K, Asami J, Kammermeier PJ, Maddox DM, Furukawa T, Inoue T, Sampath AP, Martemyanov KA

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2009 July 2229 (29):9301-13. Epub 1900 01 01.

Beqollari D, Kammermeier PJ

European journal of pharmacology.. 2008 July 28589 (1-3):49-52. Epub 06/19/2008.

The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu(6) receptors

Beqollari,D.; Kammermeier,P. J.;.

Eur.J.Pharmacol. 2008; 589(1-3): 49-52.

Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neurons

Kammermeier,P. J.;.

J.Neurosci. 2008; 28(34): 8560-8567.

Kammermeier PJ, Worley PF

Proceedings of the National Academy of Sciences of the United States of America.. 2007 April 3104 (14):6055-60. Epub 03/26/2007.

Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors

Kammermeier,P. J.; Worley,P. F.;.

Proc.Natl.Acad.Sci.U.S.A. 2007; 104(14): 6055-6060.

Kammermeier PJ

BMC neuroscience.. 2006 January 47 :1. Epub 01/04/2006.

G protein coupling profile of mGluR6 and expression of G alpha proteins in retinal ON bipolar cells

Tian,L.; Kammermeier,P. J.;.

Vis.Neurosci. 2006; 23(6): 909-916.

Tian L, Kammermeier PJ

Visual neuroscience.. 2006 23 (6):909-16. Epub 1900 01 01.

Kammermeier PJ, Yun J

The Journal of pharmacology and experimental therapeutics.. 2005 February 312 (2):502-8. Epub 10/01/2004.

Kammermeier PJ, Davis MI, Ikeda SR

Molecular pharmacology.. 2003 January 63 (1):183-91. Epub 1900 01 01.

Kammermeier PJ, Ikeda SR

Neuroscience letters.. 2002 September 27330 (3):260-4. Epub 1900 01 01.

Ikeda SR, Kammermeier PJ

Neuron.. 2002 August 135 (3):411-2. Epub 1900 01 01.

Kammermeier PJ, Ikeda SR

Journal of neurophysiology.. 2002 April 87 (4):1669-76. Epub 1900 01 01.

Kammermeier PJ, Ikeda SR

BMC neuroscience.. 2001 2 :15. Epub 10/08/2001.

Kammermeier PJ, Xiao B, Tu JC, Worley PF, Ikeda SR

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2000 October 120 (19):7238-45. Epub 1900 01 01.

Kammermeier PJ, Ruiz-Velasco V, Ikeda SR

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2000 August 120 (15):5623-9. Epub 1900 01 01.

Ikeda SR, Jeong SW, Kammermeier PJ, Ruiz-Velasco V, King MM

Neuroscience letters.. 1999 August 27271 (3):163-6. Epub 1900 01 01.

Kammermeier PJ, Ikeda SR

Neuron.. 1999 April 22 (4):819-29. Epub 1900 01 01.

Kammermeier PJ, Jones SW

Journal of neurophysiology.. 1998 January 79 (1):410-7. Epub 1900 01 01.

Kammermeier PJ, Jones SW

Journal of neurophysiology.. 1997 January 77 (1):465-75. Epub 1900 01 01.

Elmslie KS, Kammermeier PJ, Jones SW

Neuron.. 1994 July 13 (1):217-28. Epub 1900 01 01.

Elmslie KS, Kammermeier PJ, Jones SW

The Journal of physiology.. 1992 October 456 :107-23. Epub 1900 01 01.