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Joshua C. Munger, Ph.D.

Joshua C. Munger, Ph.D.

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About Me

Faculty Appointments

Professor - Department of Biochemistry and Biophysics (SMD)

Professor - Department of Microbiology and Immunology (SMD) - Joint

Research

A major focus of our laboratory is human cytomegalovirus (HCMV), a herpes virus, which is the leading cause of congenital viral infection, occurring in approximately 1% of all live births. Congenital HCMV infection results in central nervous system damage in the majority of symptomatic newborns. HC...
A major focus of our laboratory is human cytomegalovirus (HCMV), a herpes virus, which is the leading cause of congenital viral infection, occurring in approximately 1% of all live births. Congenital HCMV infection results in central nervous system damage in the majority of symptomatic newborns. HCMV infection also poses a serious health risk to immunosuppressed individuals, increasing morbidity in the elderly and in patients receiving immunosuppressive chemotherapy, including cancer patients, transplant recipients, and AIDS patients.
The majority of the projects in our lab study the interfaces between viruses and the host cell that determine the outcome of infection. Specifically, we focus on how viruses usurp cellular metabolic controls and subvert cellular anti-viral signaling to support productive infection. The goal of our laboratory is to increase our mechanistic understanding of these processes to identify novel avenues for therapeutic intervention that could prevent virally-associated pathogenesis.

The global SARS-CoV-2 pandemic is responsible for hundreds of thousands of deaths globally. Anti-viral therapeutic strategies are desperately needed to attenuate SARS-CoV-2-associated disease. We have initiated a high-throughput pharmacologic screen of a unique metabolism-focused compound library to identify drugs that limit coronavirus infection in pulmonary human fibroblasts. Our preliminary data has identified several compounds that substantially inhibit coronavirus infection. Our laboratory is in the process of validating the anti-viral activity of these compounds against SARS-CoV-2. In addition, we are elucidating how coronaviruses modulate cellular metabolism to support productive infection in an attempt to identify viral metabolic vulnerabilities that might be targeted for further therapeutic development.

Publications

Journal Articles

Soto CA, Lesch ML, Becker JL, Sharipol A, Khan A, Schafer XL, Becker MW, Munger JC, Frisch BJ

bioRxiv : the preprint server for biology.. 2024 August 16 Epub 08/16/2024.

Blick-Nitko SK, Ture SK, Schafer XL, Munger JC, Livada AC, Li C, Maurya P, Rondina MT, Morrell CN

Blood advances.. 2024 August 12 Epub 08/12/2024.

Asantewaa G, Tuttle ET, Ward NP, Kang YP, Kim Y, Kavanagh ME, Girnius N, Chen Y, Rodriguez K, Hecht F, Zocchi M, Smorodintsev-Schiller L, Scales TQ, Taylor K, Alimohammadi F, Duncan RP, Sechrist ZR, Agostini-Vulaj D, Schafer XL, Chang H, Smith ZR, O'Connor TN, Whelan S, Selfors LM, Crowdis J, Gray GK, Bronson RT, Brenner D, Rufini A, Dirksen RT, Hezel AF, Huber AR, Munger J, Cravatt BF, Vasiliou V, Cole CL, DeNicola GM, Harris IS

Nature communications.. 2024 July 2115 (1):6152. Epub 07/21/2024.

Zhang K, Eldin P, Ciesla JH, Briant L, Lentini JM, Ramos J, Cobb J, Munger J, Fu D

eLife.. 2024 May 3012 Epub 05/30/2024.

Ciesla J, Huang KL, Wagner EJ, Munger J

PLoS pathogens.. 2024 May 20 (5):e1012058. Epub 05/20/2024.

Rasmussen AL, Gronvall GK, Lowen AC, Goodrum F, Alwine J, Andersen KG, Anthony SJ, Baines J, Banerjee A, Broadbent AJ, Brooke CB, Campos SK, Caposio P, Casadevall A, Chan GC, Cliffe AR, Collins-McMillen D, Connell N, Damania B, Daugherty MD, Debbink K, Dermody TS, DiMaio D, Duprex WP, Emerman M, Galloway DA, Garry RF, Goldstein SA, Greninger AL, Hartman AL, Hogue BG, Horner SM, Hotez PJ, Jung JU, Kamil JP, Karst SM, Laimins L, Lakdawala SS, Landais I, Letko M, Lindenbach B, Liu S-L, Luftig M, McFadden G, Mehle A, Morrison J, Moscona A, Mühlberger E, Munger J, Münger K, Murphy E, Neufeldt CJ, Nikolich JZ, O'Connor CM, Pekosz A, Permar SR, Pfeiffer JK, Popescu SV, Purdy JG, Racaniello VR, Rice CM, Runstadler JA, Sapp MJ, Scott RS, Smith GA, Sorrell EM, Speranza E, Streblow D, Tibbetts SA, Toth Z, Van Doorslaer K, Weiss SR, White EA, White TM, Wobus CE, Worobey M, Yamaoka S, Yurochko A

Journal of virology.. 2024 January 2398 (1):e0179123. Epub 01/03/2024.

Raymonda MH, Rodríguez-Sánchez I, Schafer XL, Smorodintsev-Schiller L, Harris IS, Munger J

mBio.. 2024 January 1615 (1):e0303123. Epub 12/20/2023.

Wu J, Subbaiah KCV, Hedaya O, Chen S, Munger J, Tang WHW, Yan C, Yao P

Cardiovascular research.. 2023 November 15119 (14):2441-2457. Epub 1900 01 01.

Dunn DM, Pack LJ, Munger JC

bioRxiv : the preprint server for biology.. 2023 July 26 Epub 07/26/2023.

Goodrum F, Lowen A, Lakdawala S, Alwine J, Casadevall A, Imperiale M, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, Boon A, Boulant S, Brandt C, Broadbent A, Brooke C, Cameron C, Campos S, Caposio P, Chan G, Cliffe A, Coffin J, Collins K, Damania B, Daugherty M, Debbink K, DeCaprio J, Dermody T, Dikeakos J, DiMaio D, Dinglasan R, Duprex WP, Dutch R, Elde N, Emerman M, Enquist L, Fane B, Fernandez-Sesma A, Flenniken M, Frappier L, Frieman M, Frueh K, Gack M, Gaglia M, Gallagher T, Galloway D, García-Sastre A, Geballe A, Glaunsinger B, Goff S, Greninger A, Hancock M, Harris E, Heaton N, Heise M, Heldwein E, Hogue B, Horner S, Hutchinson E, Hyser J, Jackson W, Kalejta R, Kamil J, Karst S, Kirchhoff F, Knipe D, Kowalik T, Lagunoff M, Laimins L, Langlois R, Lauring A, Lee B, Leib D, Liu SL, Longnecker R, Lopez C, Luftig M, Lund J, Manicassamy B, McFadden G, McIntosh M, Mehle A, Miller WA, Mohr I, Moody C, Moorman N, Moscona A, Mounce B, Munger J, Münger K, Murphy E, Naghavi M, Nelson J, Neufeldt C, Nikolich J, O'Connor C, Ono A, Orenstein W, Ornelles D, Ou JH, Parker J, Parrish C, Pekosz A, Pellett P, Pfeiffer J, Plemper R, Polyak S, Purdy J, Pyeon D, Quinones-Mateu M, Renne R, Rice C, Schoggins J, Roller R, Russell C, Sandri-Goldin R, Sapp M, Schang L, Schmid S, Schultz-Cherry S, Semler B, Shenk T, Silvestri G, Simon V, Smith G, Smith J, Spindler K, Stanifer M, Subbarao K, Sundquist W, Suthar M, Sutton T, Tai A, Tarakanova V, tenOever B, Tibbetts S, Tompkins S, Toth Z, van Doorslaer K, Vignuzzi M, Wallace N, Walsh D, Weekes M, Weinberg J, Weitzman M, Weller S, Whelan S, White E, Williams B, Wobus C, Wong S, Yurochko A

mBio.. 2023 February 2814 (1):e0018823. Epub 01/26/2023.

Moreno I, Rodríguez-Sánchez I, Schafer X, Munger J

Proceedings of the National Academy of Sciences of the United States of America.. 2022 December 6119 (49):e2205789119. Epub 12/02/2022.

Ciesla J, Moreno I, Munger J

PLoS pathogens.. 2022 July 18 (7):e1010722. Epub 07/14/2022.

Raymonda MH, Ciesla JH, Monaghan M, Leach J, Asantewaa G, Smorodintsev-Schiller LA, Lutz MM, Schafer XL, Takimoto T, Dewhurst S, Munger J, Harris IS

Virology.. 2022 January 566 :60-68. Epub 11/27/2021.

Monaghan M, Munger J

Journal of virology.. 2021 April 1295 (9)Epub 04/12/2021.

Dunn DM, Rodriguez-Sanchez I, Schafer X, Munger J

Journal of virology.. 2021 March 195 (5)Epub 12/02/2020.

Dunn DM, Munger J

Frontiers in cellular and infection microbiology.. 2020 10 :384. Epub 07/29/2020.

Goodwin CM, Schafer X, Munger J

Journal of virology.. 2019 December 193 (23)Epub 11/13/2019.

Meade N, King M, Munger J, Walsh D

Journal of virology.. 2019 August 193 (15)Epub 07/17/2019.

Goodwin CM, Munger J

Journal of virology.. 2019 May 193 (9)Epub 04/17/2019.

Rodríguez-Sánchez I, Munger J

Viruses.. 2019 March 1911 (3)Epub 03/19/2019.

King MW, Munger J

Virology.. 2019 March 529 :186-194. Epub 01/26/2019.

Rodríguez-Sánchez I, Schafer XL, Monaghan M, Munger J

PLoS pathogens.. 2019 January 15 (1):e1007569. Epub 01/24/2019.

Goodwin CM, Ciesla JH, Munger J

Viruses.. 2018 August 2110 (9)Epub 08/21/2018.

Nadtochiy SM, Wang YT, Nehrke K, Munger J, Brookes PS

Journal of molecular and cellular cardiology.. 2018 August 121 :155-162. Epub 06/26/2018.

Zhang J, Wang YT, Miller JH, Day MM, Munger JC, Brookes PS

Cell reports.. 2018 May 2923 (9):2617-2628. Epub 1900 01 01.

Nadtochiy SM, Wang YT, Zhang J, Nehrke K, Schafer X, Welle K, Ghaemmaghami S, Munger J, Brookes PS

The Biochemical journal.. 2017 August 10474 (16):2829-2839. Epub 08/10/2017.

Murphy PS, Wang J, Bhagwat SP, Munger JC, Janssen WJ, Wright TW, Elliott MR

Cell death and differentiation.. 2017 March 24 (3):559-570. Epub 01/06/2017.

Smith B, Schafer XL, Ambeskovic A, Spencer CM, Land H, Munger J

Cell reports.. 2016 October 1117 (3):821-836. Epub 1900 01 01.

Nadtochiy SM, Schafer X, Fu D, Nehrke K, Munger J, Brookes PS

The Journal of biological chemistry.. 2016 September 16291 (38):20188-97. Epub 08/10/2016.

Xu S, Schafer X, Munger J

Journal of virology.. 2016 May 90 (9):4346-4356. Epub 04/14/2016.

Hollenbaugh JA, Montero C, Schinazi RF, Munger J, Kim B

Virology.. 2016 April 491 :106-14. Epub 02/16/2016.

Campbell A, Bushman J, Munger J, Noble M, Pröschel C, Mayer-Pröschel M

Glia.. 2016 February 64 (2):227-39. Epub 10/15/2015.

Goodwin CM, Xu S, Munger J

Trends in microbiology.. 2015 December 23 (12):789-798. Epub 10/01/2015.

Nadtochiy SM, Urciuoli W, Zhang J, Schafer X, Munger J, Brookes PS

Journal of molecular and cellular cardiology.. 2015 November 88 :64-72. Epub 09/24/2015.

Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM

Current opinion in biotechnology.. 2015 August 34 :189-201. Epub 02/28/2015.

Xu S, Spencer CM, Munger J

Journal of virology.. 2015 June 89 (12):6406-17. Epub 04/08/2015.

DeVito SR, Ortiz-Riaño E, Martínez-Sobrido L, Munger J

Proceedings of the National Academy of Sciences of the United States of America.. 2014 December 16111 (50):18019-24. Epub 12/03/2014.

Mathers C, Schafer X, Martinez-Sobrido L, Munger J

Journal of virology.. 2014 December 88 (24):14289-300. Epub 10/01/2014.

Proschel C, Stripay JL, Shih CH, Munger JC, Noble MD

EMBO molecular medicine.. 2014 April 6 (4):504-18. Epub 01/29/2014.

Ortiz-Riaño E, Ngo N, Devito S, Eggink D, Munger J, Shaw ML, de la Torre JC, Martínez-Sobrido L

Journal of virology.. 2014 January 88 (2):878-89. Epub 11/06/2013.

Mathers C, Spencer CM, Munger J

PloS one.. 2014 9 (2):e88101. Epub 02/05/2014.

Pei S, Minhajuddin M, Callahan KP, Balys M, Ashton JM, Neering SJ, Lagadinou ED, Corbett C, Ye H, Liesveld JL, O'Dwyer KM, Li Z, Shi L, Greninger P, Settleman J, Benes C, Hagen FK, Munger J, Crooks PA, Becker MW, Jordan CT

The Journal of biological chemistry.. 2013 November 22288 (47):33542-33558. Epub 10/02/2013.

Sasaki M, Knobbe CB, Munger JC, Lind EF, Brenner D, Brüstle A, Harris IS, Holmes R, Wakeham A, Haight J, You-Ten A, Li WY, Schalm S, Su SM, Virtanen C, Reifenberger G, Ohashi PS, Barber DL, Figueroa ME, Melnick A, Zúñiga-Pflücker JC, Mak TW

Nature.. 2012 August 30488 (7413):656-9. Epub 1900 01 01.

McArdle J, Moorman NJ, Munger J

PLoS pathogens.. 2012 January 8 (1):e1002502. Epub 01/26/2012.

Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, Finkelstein D, McCormick LL, Fitzgerald P, Chi H, Munger J, Green DR

Immunity.. 2011 December 2335 (6):871-82. Epub 1900 01 01.

Hollenbaugh JA, Munger J, Kim B

Virology.. 2011 July 5415 (2):153-9. Epub 05/11/2011.

Spencer CM, Schafer XL, Moorman NJ, Munger J

Journal of virology.. 2011 June 85 (12):5814-24. Epub 04/06/2011.

McArdle J, Schafer XL, Munger J

Journal of virology.. 2011 January 85 (2):705-14. Epub 11/17/2010.

Munger J, Bennett BD, Parikh A, Feng XJ, McArdle J, Rabitz HA, Shenk T, Rabinowitz JD

Nature biotechnology.. 2008 October 26 (10):1179-86. Epub 09/28/2008.

Munger J, Bajad SU, Coller HA, Shenk T, Rabinowitz JD

PLoS pathogens.. 2006 December 2 (12):e132. Epub 1900 01 01.

Munger J, Yu D, Shenk T

Journal of virology.. 2006 April 80 (7):3541-8. Epub 1900 01 01.

Benetti L, Munger J, Roizman B

Journal of virology.. 2003 June 77 (11):6567-73. Epub 1900 01 01.

Munger J, Hagglund R, Roizman B

Virology.. 2003 January 20305 (2):364-70. Epub 1900 01 01.

Cell death on demand: Herpes simplex viruses and apoptosis

Munger, J.; Zhou, G.; Roizman, B.;.

In C. D. O?Connor (ed.), Microbial Subversion of Host Cells, Cambridge University Press, Cambridge. 2003; : 229-245.

Hagglund R, Munger J, Poon AP, Roizman B

Journal of virology.. 2002 January 76 (2):743-54. Epub 1900 01 01.

Munger J, Roizman B

Proceedings of the National Academy of Sciences of the United States of America.. 2001 August 2898 (18):10410-5. Epub 08/21/2001.

Munger J, Chee AV, Roizman B

Journal of virology.. 2001 June 75 (12):5491-7. Epub 1900 01 01.

Galvan V, Brandimarti R, Munger J, Roizman B

Journal of virology.. 2000 February 74 (4):1931-8. Epub 1900 01 01.