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Alayna E. Loiselle, Ph.D.

Alayna E. Loiselle, Ph.D.

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Office (585) 275-7239

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About Me

Faculty Appointments

Associate Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD)

Associate Professor - Department of Biomedical Engineering (SMD) - Joint

Associate Professor - Department of Pathology and Laboratory Medicine (SMD) - Joint

Credentials

Education

Post-doctoral Fellowship | Penn State College of Medicine. Orthopaedics. 2013

PhD | University of Rochester School of Medicine & Dentistry. Pathology. 2009

BS | Niagara University. Biology. 2004

Awards

Senior Leader Education & Development (SLED) Program. 2021 - 2023

Goldner Pioneer Award. 2014

Bond Bradley Award- Outstanding Postdoctoral Fellow. 2013

Fellows Forum on Metabolic Bone Disease Travel Award. 2013

Young Investigator Award. 2012

Fellows Forum on Metabolic Bone Disease Travel Award. 2012

New Investigator Research Award Finalist. 2012

Alice L. Jee Young Investigator Award. 2011

New Investigator Research Award Finalist. 2011

Young Investigator Travel Award. 2011

Travel Award. 2008

Research

The overarching goal of our research program is to identify novel strategies to improve flexor tendon healing by reducing the formation of range of motion (ROM) limiting adhesions, without compromising mechanical strength. Flexor tendons glide through a synovial sheath to facilitate digit ROM and mo...
The overarching goal of our research program is to identify novel strategies to improve flexor tendon healing by reducing the formation of range of motion (ROM) limiting adhesions, without compromising mechanical strength. Flexor tendons glide through a synovial sheath to facilitate digit ROM and movement of the hand. Following injury, up to 40% of primary flexor tendon repairs will heal with unsatisfactory outcomes. The primary complication involves a robust scar tissue response, which forms adhesions between the tendon and synovial sheath, resulting impaired gliding function.
We have developed a novel murine model of intrasynovial FT healing, which mimics many aspects of healing in humans including abundant adhesion formation, impaired ROM and early decrements in tendon strength. We continue to use this model to gain a greater understanding of the cell and molecular processes involved in scar and adhesion formation in order to identify therapeutic targets to improve FT healing

Publications

Journal Articles

Mora KE, Mlawer SJ, Loiselle AE, Buckley MR

Small.. 2024 July 5 :e2401015. Epub 07/05/2024.

Korcari A, Nichols AEC, Buckley MR, Loiselle AE

eLife.. 2024 January 313 Epub 01/03/2024.

Adjei-Sowah E, Benoit DSW, Loiselle AE

Tissue engineering. Part B, Reviews.. 2023 August 29 (4):369-386. Epub 03/08/2023.

Korcari A, Przybelski SJ, Gingery A, Loiselle AE

Connective tissue research.. 2023 January 64 (1):1-13. Epub 07/28/2022.

Geary MB, Orner CA, Shammas H, Reuter JM, Loiselle AE, Giordano BD, Wu CL

Journal of hip preservation surgery.. 2023 10 (3-4):158-165. Epub 07/29/2023.

Muscat S, Nichols AEC, Gira E, Loiselle AE

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2022 November 36 (11):e22607. Epub 1900 01 01.

Korcari A, Buckley MR, Loiselle AE

Journal of the mechanical behavior of biomedical materials.. 2022 June 130 :105192. Epub 03/23/2022.

Kenney HM, Wu CL, Loiselle AE, Xing L, Ritchlin CT, Schwarz EM

Arthritis research & therapy.. 2022 March 724 (1):64. Epub 03/07/2022.

Mora KE, Mlawer SJ, Bae AJ, Richards MS, Loiselle AE, Buckley MR

Journal of biomechanics.. 2022 February 132 :110920. Epub 12/20/2021.

Dakin SG, Loiselle AE, Traweger A

Frontiers in bioengineering and biotechnology.. 2022 10 :928144. Epub 05/13/2022.

Korcari A, Muscat S, McGinn E, Buckley MR, Loiselle AE

PloS one.. 2022 17 (10):e0274227. Epub 10/14/2022.

Best KT, Studentsova V, Ackerman JE, Nichols AEC, Myers M, Cobb J, Knapp E, Awad HA, Loiselle AE

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2021 July 39 (7):1572-1580. Epub 06/09/2020.

Nichols AEC, Muscat SN, Miller SE, Green LJ, Richards MS, Loiselle AE

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2021 July 35 (7):e21733. Epub 1900 01 01.

Qiu B, Cobb J, Loiselle AE, Ketonis C

The Journal of bone and joint surgery. American volume.. 2021 March 3103 (5):432-438. Epub 1900 01 01.

Ackerman JE, Best KT, Muscat SN, Loiselle AE

Current rheumatology reports.. 2021 February 1023 (3):15. Epub 02/10/2021.

Best KT, Korcari A, Mora KE, Nichols AE, Muscat SN, Knapp E, Buckley MR, Loiselle AE

eLife.. 2021 January 2210 Epub 01/22/2021.

Best KT, Nichols AEC, Knapp E, Hammert WC, Ketonis C, Jonason JH, Awad HA, Loiselle AE

Science signaling.. 2020 November 1713 (658)Epub 11/17/2020.

Feigenson M, Jonason JH, Shen J, Loiselle AE, Awad HA, O'Keefe RJ

Annals of biomedical engineering.. 2020 March 48 (3):927-939. Epub 04/12/2019.

Loiselle AE, Oh I, Nichols AEC

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 January 38 (1):13-22. Epub 06/24/2019.

Ackerman JE, Studentsova V, Myers M, Buckley MR, Richards MS, Loiselle AE

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 November 37 (11):2476-2485. Epub 07/12/2019.

Best KT, Lee FK, Knapp E, Awad HA, Loiselle AE

Scientific reports.. 2019 July 299 (1):10926. Epub 07/29/2019.

Nichols AEC, Best KT, Loiselle AE

Translational research : the journal of laboratory and clinical medicine.. 2019 July 209 :156-168. Epub 02/08/2019.

Best KT, Loiselle AE

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2019 July 33 (7):8578-8587. Epub 04/05/2019.

Studentsova V, Knapp E, Loiselle AE

Bone reports.. 2019 June 10 :100197. Epub 02/05/2019.

Ackerman JE, Nichols AE, Studentsova V, Best KT, Knapp E, Loiselle AE

eLife.. 2019 May 248 Epub 05/24/2019.

Studentsova V, Mora KM, Glasner MF, Buckley MR, Loiselle AE

Scientific reports.. 2018 June 158 (1):9218. Epub 06/15/2018.

Ackerman JE, Bah I, Jonason JH, Buckley MR, Loiselle AE

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2017 December 35 (12):2716-2724. Epub 05/03/2017.

Ackerman JE, Best KT, O'Keefe RJ, Loiselle AE

Scientific reports.. 2017 August 177 (1):8658. Epub 08/17/2017.

Ackerman JE, Geary MB, Orner CA, Bawany F, Loiselle AE

PloS one.. 2017 12 (7):e0181127. Epub 07/07/2017.

Ackerman JE, Loiselle AE

Journal of visualized experiments : JoVE.. 2016 September 19 (115)Epub 09/19/2016.

Orner CA, Geary MB, Hammert WC, O'Keefe RJ, Loiselle AE

Plastic and reconstructive surgery.. 2016 March 137 (3):545e-553e. Epub 1900 01 01.

Loiselle AE, Kelly M, Hammert WC

The Journal of hand surgery.. 2016 January 41 (1):144-9; quiz 149. Epub 12/01/2015.

Loiselle AE, Yukata K, Geary MB, Kondabolu S, Shi S, Jonason JH, Awad HA, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2015 June 33 (6):859-66. Epub 1900 01 01.

Zhang M, Feigenson M, Sheu TJ, Awad HA, Schwarz EM, Jonason JH, Loiselle AE, O'Keefe RJ

Bone.. 2015 March 72 :92-100. Epub 11/29/2014.

Lee DJ, Southgate RD, Farhat YM, Loiselle AE, Hammert WC, Awad HA, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2015 January 33 (1):17-24. Epub 09/29/2014.

Geary MB, Orner CA, Bawany F, Awad HA, Hammert WC, O'Keefe RJ, Loiselle AE

PloS one.. 2015 10 (8):e0136351. Epub 08/27/2015.

Govey PM, Jacobs JM, Tilton SC, Loiselle AE, Zhang Y, Freeman WM, Waters KM, Karin NJ, Donahue HJ

Journal of biomechanics.. 2014 June 347 (8):1838-45. Epub 03/25/2014.

Lloyd SA, Loiselle AE, Zhang Y, Donahue HJ

BMC musculoskeletal disorders.. 2014 April 915 :122. Epub 04/09/2014.

Lloyd SA, Loiselle AE, Zhang Y, Donahue HJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2014 February 29 (2):275-86. Epub 1900 01 01.

Lloyd SA, Loiselle AE, Zhang Y, Donahue HJ

Bone.. 2013 November 57 (1):76-83. Epub 07/24/2013.

Loiselle AE, Wei L, Faryad M, Paul EM, Lewis GS, Gao J, Lakhtakia A, Donahue HJ

Tissue engineering. Part A.. 2013 August 19 (15-16):1704-12. Epub 04/25/2013.

Loiselle AE, Jiang JX, Donahue HJ

Bone.. 2013 June 54 (2):205-12. Epub 10/13/2012.

Govey PM, Loiselle AE, Donahue HJ

Current osteoporosis reports.. 2013 June 11 (2):83-91. Epub 1900 01 01.

Loiselle AE, Paul EM, Lewis GS, Donahue HJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2013 January 31 (1):147-54. Epub 06/20/2012.

Loiselle AE, Lloyd SA, Paul EM, Lewis GS, Donahue HJ

PloS one.. 2013 8 (11):e81399. Epub 11/08/2013.

Loiselle AE, Frisch BJ, Wolenski M, Jacobson JA, Calvi LM, Schwarz EM, Awad HA, O'Keefe RJ

PloS one.. 2012 7 (7):e40602. Epub 07/11/2012.

Lim JY, Loiselle AE, Lee JS, Zhang Y, Salvi JD, Donahue HJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2011 November 29 (11):1627-33. Epub 04/20/2011.

Katzel EB, Wolenski M, Loiselle AE, Basile P, Flick LM, Langstein HN, Hilton MJ, Awad HA, Hammert WC, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2011 May 29 (5):684-93. Epub 09/14/2010.

Gunnell LM, Jonason JH, Loiselle AE, Kohn A, Schwarz EM, Hilton MJ, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2010 August 25 (8):1784-97. Epub 1900 01 01.

Xie C, Liang B, Xue M, Lin AS, Loiselle A, Schwarz EM, Guldberg RE, O'Keefe RJ, Zhang X

The American journal of pathology.. 2009 August 175 (2):772-85. Epub 07/23/2009.

Loiselle AE, Bragdon GA, Jacobson JA, Hasslund S, Cortes ZE, Schwarz EM, Mitten DJ, Awad HA, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2009 June 27 (6):833-40. Epub 1900 01 01.

Books

Musculoskeletal Tissue Engineering (2021)

Chapter: Tendon and Ligament Tissue Engineering

Authors: A Korcari, AEC Nichols, M O'Neil, AE Loiselle

Publisher: Elsevier 2021

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (2018)

Chapter: Skeletal Healing

Authors: AE Loiselle, MJ Zuscik

Publisher: Wiley 2018