Ruchira Singh, Ph.D.
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Ruchira Singh, Ph.D.
About Me
Faculty Appointments
Associate Professor - Department of Ophthalmology (SMD)
Dean's Professorship - Department of Ophthalmology (SMD)
Associate Professor - Department of Biomedical Genetics (SMD) - Joint
Associate Professor - Center for Visual Science A&S (RC) - Joint
Research
The retina is an extension of the central nervous system that has been shown to share the pathological manifestations of a number of neurological disorders, including Alzheimer's disease, Parkinson's and multiple sclerosis. Moreover, patients with age-related macular degeneration (AMD), a disease of the central retina, have been shown to have non vision–related cognitive decline. Furthermore, a number of physiological processes that are affected in neuro-degenerative diseases are also impacted in retinal degenerative diseases. To cite a few examples, perturbation in phagocytic clearance, iron metabolism, polarized fluid transport and blood–tissue barrier function are all major cellular characteristics of degenerative diseases of both the retina and the brain. Therefore studying mechanisms of specific retinal degenerative diseases also has significant relevance for understanding other neurological disorders.
The current projects in the laboratory utilize patient-derived hiPSCs for:
• Studying the role of individual cell layer and intercellular interaction in retinal physiology and disease development
• Delineating the disease mechanism(s) of inherited retinal degenerative disease(s) and age-related macular degeneration
• Elucidating the role of gene-environment interaction in the pathophysiology of macular degeneration
More details about specific projects can be found on my lab website
Publications
Journal Articles
Dalvi S, Roll M, Chatterjee A, Kumar LK, Bhogavalli A, Foley N, Arduino C, Spencer W, Reuben-Thomas C, Ortolan D, Pébay A, Bharti K, Anand-Apte B, Singh R
Developmental cell.. 2024 September 26 Epub 09/26/2024.
Grenell A, Singh C, Raju M, Wolk A, Dalvi S, Jang GF, Crabb JS, Hershberger CE, Manian KV, Hernandez K, Crabb JW, Singh R, Du J, Anand-Apte B
Molecular metabolism.. 2024 July 22 :101995. Epub 07/22/2024.
Han J, Chear S, Talbot J, Swier V, Booth C, Reuben-Thomas C, Dalvi S, Weimer JM, Hewitt AW, Cook AL, Singh R
bioRxiv : the preprint server for biology.. 2024 June 13 Epub 06/13/2024.
Swier VJ, White KA, Johnson TB, Wang X, Han J, Pearce DA, Singh R, Drack AV, Pfeifer W, Rogers CS, Brudvig JJ, Weimer JM
Disease models & mechanisms.. 2023 August 116 (8)Epub 08/07/2023.
Dalvi S, Chatterjee A, Singh R
Cell stem cell.. 2023 March 230 (3):243-245. Epub 1900 01 01.
Chatterjee A, Singh R
Frontiers in cell and developmental biology.. 2023 11 :1059141. Epub 04/25/2023.
Manian KV, Galloway CA, Dalvi S, Emanuel AA, Mereness JA, Black W, Winschel L, Soto C, Li Y, Song Y, DeMaria W, Kumar A, Slukvin I, Schwartz MP, Murphy WL, Anand-Apte B, Chung M, Benoit DSW, Singh R
Cell stem cell.. 2021 May 628 (5):846-862.e8. Epub 03/29/2021.
Manian KV, Galloway CA, Dalvi S, Emanuel AA, Mereness JA, Black W, Winschel L, Soto C, Li Y, Song Y, DeMaria W, Kumar A, Slukvin I, Schwartz MP, Murphy WL, Anand-Apte B, Chung M, Benoit DSW, Singh R
Cell stem cell.. 2021 May 628 (5):978. Epub 1900 01 01.
Tang C, Han J, Dalvi S, Manian K, Winschel L, Volland S, Soto CA, Galloway CA, Spencer W, Roll M, Milliner C, Bonilha VL, Johnson TB, Latchney L, Weimer JM, Augustine EF, Mink JW, Gullapalli VK, Chung M, Williams DS, Singh R
Communications biology.. 2021 February 54 (1):161. Epub 02/05/2021.
Gamm DM, Clark E, Capowski EE, Singh R
American journal of ophthalmology.. 2019 October 206 :113-131. Epub 05/10/2019.
Anand-Apte B, Chao JR, Singh R, Stöhr H
Journal of neuroscience research.. 2019 January 97 (1):88-97. Epub 08/21/2018.
Dalvi S, Galloway CA, Winschel L, Hashim A, Soto C, Tang C, MacDonald LA, Singh R
Cell death discovery.. 2019 5 :96. Epub 05/16/2019.
Dalvi S, Galloway CA, Singh R
Advances in experimental medicine and biology.. 2019 1186 :1-31. Epub 1900 01 01.
Galloway CA, Dalvi S, Shadforth AMA, Suzuki S, Wilson M, Kuai D, Hashim A, MacDonald LA, Gamm DM, Harkin DG, Singh R
Investigative ophthalmology & visual science.. 2018 June 159 (7):2792-2800. Epub 1900 01 01.
Galloway CA, Dalvi S, Hung SSC, MacDonald LA, Latchney LR, Wong RCB, Guymer RH, Mackey DA, Williams DS, Chung MM, Gamm DM, Pébay A, Hewitt AW, Singh R
Proceedings of the National Academy of Sciences of the United States of America.. 2017 September 26114 (39):E8214-E8223. Epub 09/06/2017.
Singh R, Kuai D, Guziewicz KE, Meyer J, Wilson M, Lu J, Smith M, Clark E, Verhoeven A, Aguirre GD, Gamm DM
Molecular therapy : the journal of the American Society of Gene Therapy.. 2015 November 23 (11):1700-1711. Epub 08/24/2015.
Phillips MJ, Perez ET, Martin JM, Reshel ST, Wallace KA, Capowski EE, Singh R, Wright LS, Clark EM, Barney PM, Stewart R, Dickerson SJ, Miller MJ, Percin EF, Thomson JA, Gamm DM
Stem cells.. 2014 June 32 (6):1480-92. Epub 1900 01 01.
Singh R, Phillips MJ, Kuai D, Meyer J, Martin JM, Smith MA, Perez ET, Shen W, Wallace KA, Capowski EE, Wright LS, Gamm DM
Investigative ophthalmology & visual science.. 2013 October 1754 (10):6767-78. Epub 10/17/2013.
McDowell TS, Wang ZY, Singh R, Bjorling D
Neuroscience letters.. 2013 September 13551 :34-8. Epub 07/12/2013.
Gamm DM, Phillips MJ, Singh R
Expert review of ophthalmology.. 2013 June 18 (3):213-216. Epub 1900 01 01.
Singh R, Shen W, Kuai D, Martin JM, Guo X, Smith MA, Perez ET, Phillips MJ, Simonett JM, Wallace KA, Verhoeven AD, Capowski EE, Zhang X, Yin Y, Halbach PJ, Fishman GA, Wright LS, Pattnaik BR, Gamm DM
Human molecular genetics.. 2013 February 122 (3):593-607. Epub 11/08/2012.
Yamauchi D, Nakaya K, Raveendran NN, Harbidge DG, Singh R, Wangemann P, Marcus DC
BMC physiology. 2010 January 2910 :1. Epub 01/29/2010.
Wangemann P, Kim HM, Billings S, Nakaya K, Li X, Singh R, Sharlin DS, Forrest D, Marcus DC, Fong P
American journal of physiology. Renal physiology.. 2009 November 297 (5):F1435-47. Epub 08/19/2009.
Singh R, Wangemann P
American journal of physiology. Renal physiology.. 2008 January 294 (1):F139-48. Epub 10/24/2007.
Jabba SV, Oelke A, Singh R, Maganti RJ, Fleming S, Wall SM, Everett LA, Green ED, Wangemann P
BMC medicine.. 2006 December 224 :37. Epub 12/22/2006.
Singh R, Maganti RJ, Jabba SV, Wang M, Deng G, Heath JD, Kurn N, Wangemann P
American journal of physiology. Cell physiology.. 2005 May 288 (5):C1179-89. Epub 12/21/2004.