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Rakesh K. Singh, Ph.D., M.Phil.

Rakesh K. Singh, Ph.D., M.Phil.

Contact

Office (585) 276-6281

About Me

Like thousands of medicinal chemists across the world I frequently spin my magnetic bars overnight, scratch round bottom flasks next morning as if the molecules are hiding somewhere in the flask walls and look at my harvest anxiously standing around my dirty and disorganized chemical hood hoping tha...
Like thousands of medicinal chemists across the world I frequently spin my magnetic bars overnight, scratch round bottom flasks next morning as if the molecules are hiding somewhere in the flask walls and look at my harvest anxiously standing around my dirty and disorganized chemical hood hoping that NMR and Mass will be okay and my hunt for that elusive molecule which is going to help someone rid of his/her disease to some extent is finally complete. In this tryst, I combine alphabets of cancer biology, tumor immunology, medicinal chemistry and some rudimentary pharmacology and drug design concepts and in vitro and in vivo models of tumors for screening; and seek guidance from molecular modeling/virtual screening experts and most recently with some extraterrestrial artificial intelligence (AI) nerds to design a drug-like molecule against a protein target which physicians or researchers believe has gone awry (based on their trust in p values) and is making some one sick.

Faculty Appointments

Research Associate Professor - Department of Obstetrics and Gynecology (SMD)

Credentials

Education

PhD | India-Jamia Millia Islamia-Delhi. Medicinal Chemistry. 2003

M.Phil | India-Birla Institute of Tech and Science. Medicinal Chemistry. 1996

Awards

Ranbaxy Research Fellowship. 1999 - 2001

Senior Research Fellowship. 1997 - 1998

Research

In team with renowned physicians, immunologists, cancer biologists and molecular modelling colleagues sitting in different continents and those extraterrestrial AI nerds situated somewhere on the west coast I currently focus on developing small molecule based immunotherapeutics for treatment of high...
In team with renowned physicians, immunologists, cancer biologists and molecular modelling colleagues sitting in different continents and those extraterrestrial AI nerds situated somewhere on the west coast I currently focus on developing small molecule based immunotherapeutics for treatment of high-risk malignancies such as but not limited to:

• Ovarian cancer
• Neuroblastoma
• Medulloblastoma
• Pancreatic cancer
• Melanoma
• Colorectal cancer

Complexities of drug-discovery commerce aside, small molecule based immunotherapeutics can be a viable alternative or a great complementary armamentarium to antibody based immunotherapies for treatment of high-risk malignancies or diseases.

Patents

Derivatives of Vitamin D and Therapeutic Use Thereof

Issue date: May 11, 2011

Patent #: 1968383

Country: Europe

Inventors: Laurent Brard, Satyan Kalkunte, Rakesh K Singh

Heterocycles and Derivatives Thereof and Methods of Manufacture and Therapeutic Use

Issue date: May 05, 2015

Patent #: 9,024,039

Country: United States

Inventors: Laurent Brard, Satyan Kalkunte, Rakesh K Singh

N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use

Issue date: August 11, 2015

Patent #: 2,676,527

Country: Canada

Inventors: Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler, Rakesh K Singh

N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use

Issue date: March 25, 2015

Patent #: 2114410

Country: Europe

Inventors: Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler, Rakesh K Singh

N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use

Issue date: June 05, 2012

Patent #: 8,193,180

Country: United States

Inventors: Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler, Rakesh K Singh

Novel 7-Dehydrocholesterol Derivatives and Methods Using Same

Issue date: June 02, 2021

Patent #: 3128996

Country: Europe

Inventors: Richard G Moore, Rakesh K Singh

Novel 7-Dehydrocholesterol Derivatives and Methods Using Same

Issue date: May 29, 2018

Patent #: 9,982,010

Country: United States

Inventors: Richard G Moore, Rakesh K Singh

Therapy for Malignant Disease Comprising the Inhibition of Human Epididymal Secretory Protein E4 and Immune Checkpoint Inhibitors

Issue date: December 14, 2021

Patent #: 2,981,068

Country: Canada

Inventors: Richard G Moore, Rakesh K Singh, Naohiro Yano

Therapy for Malignant Disease

Issue date: August 13, 2019

Patent #: 10,376,535

Country: United States

Inventors: Richard G Moore, Rakesh K Singh, Naohiro Yano

Septin Proteins as Novel Biomarkers for Detection and Treatment of Mullerian Cancers

Issue date: December 09, 2020

Patent #: 3311165

Country: Europe

Inventors: Richard G Moore, Rakesh K Singh

Derivatives of Vitamin D and Therapeutic Use Thereof

Issue date: May 11, 2011

Patent #: FR1968383

Country: France

Inventors: Laurent Brard, Satyan Kalkunte, Rakesh K Singh

Derivatives of Vitamin D and Therapeutic Use Thereof

Issue date: May 11, 2011

Patent #: DE1968383

Country: Germany

Inventors: Laurent Brard, Satyan Kalkunte, Rakesh K Singh

N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use

Issue date: March 25, 2015

Patent #: FR2114410

Country: France

Inventors: Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler, Rakesh K Singh

7-Dehydrocholesterol Derivatives and Methods Using Same

Issue date: June 16, 2020

Patent #: 10,683,324

Country: United States

Inventors: Richard G Moore, Rakesh K Singh

Novel 7-Dehydrocholesterol Derivatives and Methods Using Same

Issue date: June 15, 2021

Patent #: 11,034,719

Country: United States

Inventors: Richard G Moore, Rakesh K Singh

Septin Proteins as Novel Biomarkers for Detection and Treatment of Mullerian Cancers

Issue date: December 09, 2020

Patent #: FR3311165

Country: France

Inventors: Richard G Moore, Rakesh K Singh

Septin Proteins as Novel Biomarkers for Detection and Treatment of Mullerian Cancers

Issue date: December 09, 2020

Patent #: DE3311165

Country: Germany

Inventors: Richard G Moore, Rakesh K Singh

Septin Proteins as Novel Biomarkers for Detection and Treatment of Mullerian Cancers

Issue date: December 09, 2020

Patent #: GB3311165

Country: United Kingdom

Inventors: Richard G Moore, Rakesh K Singh

Novel 7-Dehydrocholesterol Derivatives and Methods Using Same

Issue date: June 02, 2021

Patent #: FR3128996

Country: France

Inventors: Richard G Moore, Rakesh K Singh

Novel 7-Dehydrocholesterol Derivatives and Methods Using Same

Issue date: June 02, 2021

Patent #: DE3128996

Country: Germany

Inventors: Richard G Moore, Rakesh K Singh

Novel 7-Dehydrocholesterol Derivatives and Methods Using Same

Issue date: June 02, 2021

Patent #: GB3128996

Country: United Kingdom

Inventors: Richard G Moore, Rakesh K Singh

Publications

Journal Articles

Scientific reports.. 2024 September 1614 (1):21579. Epub 09/16/2024.

Sahasrabudhe DM, Liesveld JL, Minhajuddin M, Singh NA, Nath S, Kumar VM, Balys M, Evans AG, Azadniv M, Hansen JN, Becker MW, Sharon A, Thomas VK, Moore RG, Khera MK, Jordan CT, Singh RK

Scientific reports.. 2024 June 414 (1):12868. Epub 06/04/2024.

Scientific reports.. 2024 April 214 (1):7526. Epub 04/02/2024.

Kim K, Khazan N, Rowswell-Turner RB, Singh RK, Moore T, Strawderman MS, Miller JP, Snyder CWA, Awada A, Moore RG

Cancers.. 2024 February 2816 (5)Epub 02/28/2024.

Zhovmer AS, Manning A, Smith C, Nguyen A, Prince O, Sáez PJ, Ma X, Tsygankov D, Cartagena-Rivera AX, Singh NA, Singh RK, Tabdanov ED

Science advances.. 2024 January 510 (1):eadi1788. Epub 01/03/2024.

Tagay Y, Kheirabadi S, Ataie Z, Singh RK, Prince O, Nguyen A, Zhovmer AS, Ma X, Sheikhi A, Tsygankov D, Tabdanov ED

Advanced science.. 2023 November 10 (31):e2302229. Epub 09/19/2023.

Khazan N, Quarato ER, Singh NA, Snyder CWA, Moore T, Miller JP, Yasui M, Teramoto Y, Goto T, Reshi S, Hong J, Zhang N, Pandey D, Srivastava P, Morell A, Kawano H, Kawano Y, Conley T, Sahasrabudhe DM, Yano N, Miyamoto H, Aljitawi O, Liesveld J, Becker MW, Calvi LM, Zhovmer AS, Tabdanov ED, Dokholyan NV, Linehan DC, Hansen JN, Gerber SA, Sharon A, Khera MK, Jurutka PW, Rochel N, Kim KK, Rowswell-Turner RB, Singh RK, Moore RG

Cancers.. 2023 June 3015 (13)Epub 06/30/2023.

Khazan N, Kim KK, Hansen JN, Singh NA, Moore T, Snyder CWA, Pandita R, Strawderman M, Fujihara M, Takamura Y, Jian Y, Battaglia N, Yano N, Teramoto Y, Arnold LA, Hopson R, Kishor K, Nayak S, Ojha D, Sharon A, Ashton JM, Wang J, Milano MT, Miyamoto H, Linehan DC, Gerber SA, Kawar N, Singh AP, Tabdanov ED, Dokholyan NV, Kakuta H, Jurutka PW, Schor NF, Rowswell-Turner RB, Singh RK, Moore RG

Journal of medicinal chemistry.. 2022 April 2865 (8):6039-6055. Epub 04/11/2022.

Zhovmer AS, Manning A, Smith C, Hayes JB, Burnette DT, Wang J, Cartagena-Rivera AX, Dokholyan NV, Singh RK, Tabdanov ED

ACS nano.. 2021 November 2315 (11):17528-17548. Epub 10/22/2021.

Rowswell-Turner RB, Singh RK, Urh A, Yano N, Kim KK, Khazan N, Pandita R, Sivagnanalingam U, Hovanesian V, James NE, Ribeiro JR, Kadambi S, Linehan DC, Moore RG

The Journal of immunology : official journal of the American Association of Immunologists.. 2021 May 15206 (10):2478-2488. Epub 04/26/2021.

James NE, Emerson JB, Borgstadt AD, Beffa L, Oliver MT, Hovanesian V, Urh A, Singh RK, Rowswell-Turner R, DiSilvestro PA, Ou J, Moore RG, Ribeiro JR

Scientific reports.. 2020 May 2210 (1):8558. Epub 05/22/2020.

Kim KK, Singh RK, Khazan N, Kodza A, Singh NA, Jones A, Sivagnanalingam U, Towner M, Itamochi H, Turner R, Moore RG

Scientific reports.. 2020 February 2410 (1):3241. Epub 02/24/2020.

Kim KK, Turner R, Khazan N, Kodza A, Jones A, Singh RK, Moore RG

PloS one.. 2020 15 (5):e0232253. Epub 05/04/2020.

Rowswell-Turner RB, Rutishauser JA, Kim KK, Khazan N, Sivagnanalingam U, Jones AM, Singh RK, Moore RG

Translational oncology.. 2019 July 12 (7):917-924. Epub 05/10/2019.

James NE, Oliver MT, Ribeiro JR, Cantillo E, Rowswell-Turner RB, Kim KK, Chichester CO, DiSilvestro PA, Moore RG, Singh RK, Yano N, Zhao TC

Frontiers in pharmacology.. 2019 10 :216. Epub 03/19/2019.

James NE, Cantillo E, Oliver MT, Rowswell-Turner RB, Ribeiro JR, Kim KK, Chichester CO, DiSilvestro PA, Moore RG, Singh RK, Yano N, Zhao TC

Clinical and experimental immunology.. 2018 September 193 (3):327-340. Epub 1900 01 01.

Ribeiro JR, Schorl C, Yano N, Romano N, Kim KK, Singh RK, Moore RG

Journal of ovarian research.. 2016 May 179 (1):28. Epub 05/17/2016.

Kim KK, Han A, Yano N, Ribeiro JR, Lokich E, Singh RK, Moore RG

Scientific reports.. 2015 November 165 :15911. Epub 11/16/2015.

Kim KK, Abelman S, Yano N, Ribeiro JR, Singh RK, Tipping M, Moore RG

Scientific reports.. 2015 October 155 :14296. Epub 10/15/2015.

Wang Y, Han A, Chen E, Singh RK, Chichester CO, Moore RG, Singh AP, Vorsa N

International journal of oncology.. 2015 May 46 (5):1924-34. Epub 03/17/2015.

Sidhu PS, Teske K, Feleke B, Yuan NY, Guthrie ML, Fernstrum GB, Vyas ND, Han L, Preston J, Bogart JW, Silvaggi NR, Cook JM, Singh RK, Bikle DD, Arnold LA

Cancer chemotherapy and pharmacology.. 2014 October 74 (4):787-98. Epub 08/09/2014.

Lokich E, Singh RK, Han A, Romano N, Yano N, Kim K, Moore RG

Scientific reports.. 2014 June 304 :5500. Epub 06/30/2014.

Sidhu PS, Nassif N, McCallum MM, Teske K, Feleke B, Yuan NY, Nandhikonda P, Cook JM, Singh RK, Bikle DD, Arnold LA

ACS medicinal chemistry letters.. 2014 February 135 (2):199-204. Epub 1900 01 01.

Moore RG, Hill EK, Horan T, Yano N, Kim K, MacLaughlan S, Lambert-Messerlian G, Tseng YD, Padbury JF, Miller MC, Lange TS, Singh RK

Scientific reports.. 2014 January 64 :3574. Epub 01/06/2014.

Teske K, Nandhikonda P, Bogart JW, Feleke B, Sidhu P, Yuan N, Preston J, Goy R, Han L, Silvaggi NR, Singh RK, Bikle DD, Cook JM, Arnold LA

Nuclear receptor research.. 2014 1 Epub 1900 01 01.

Kawar N, Maclaughlan S, Horan TC, Uzun A, Lange TS, Kim KK, Hopson R, Singh AP, Sidhu PS, Glass KA, Shaw S, Padbury JF, Vorsa N, Arnold LA, Moore RG, Brard L, Singh RK

Genes & cancer.. 2013 November 4 (11-12):524-34. Epub 1900 01 01.

Kristjansdottir K, Kim K, Choi JS, Horan TC, Brard L, Moore RG, Singh RK

Gynecologic oncology.. 2012 August 126 (2):252-8. Epub 05/02/2012.

Kim KK, Lange TS, Singh RK, Brard L, Moore RG

BMC cancer.. 2012 April 1312 :147. Epub 04/13/2012.

Kim KK, Singh AP, Singh RK, Demartino A, Brard L, Vorsa N, Lange TS, Moore RG

International journal of oncology.. 2012 January 40 (1):227-35. Epub 09/12/2011.

Lange TS, Horan TC, Kim KK, Singh AP, Vorsa N, Brard L, Moore RG, Singh RK

Chemical biology & drug design.. 2012 January 79 (1):92-103. Epub 11/04/2011.

Singh AP, Lange TS, Kim KK, Brard L, Horan T, Moore RG, Vorsa N, Singh RK

International journal of oncology.. 2012 January 40 (1):99-108. Epub 10/06/2011.

Moore RG, Lange TS, Robinson K, Kim KK, Uzun A, Horan TC, Kawar N, Yano N, Chu SR, Mao Q, Brard L, DePaepe ME, Padbury JF, Arnold LA, Brodsky A, Shen TL, Singh RK

PloS one.. 2012 7 (4):e34443. Epub 04/03/2012.

Brard L, Lange TS, Robison K, Kim KK, Ara T, McCallum MM, Arnold LA, Moore RG, Singh RK

Gynecologic oncology.. 2011 November 123 (2):370-8. Epub 07/30/2011.

Stuckey A, Fischer A, Miller DH, Hillenmeyer S, Kim KK, Ritz A, Singh RK, Raphael BJ, Brard L, Brodsky AS

BMC cancer.. 2011 July 2211 :308. Epub 07/22/2011.

Kim KK, Kawar NM, Singh RK, Lange TS, Brard L, Moore RG

Gynecologic oncology.. 2011 July 122 (1):183-9. Epub 05/06/2011.

Singh RK, Dorf L, DeMartino A, Illenye S, Koto K, Currier EA, Ashikaga T, Kim KK, Brard L, Sholler GL

Cancer biology & therapy.. 2011 June 1511 (12):1036-45. Epub 06/15/2011.

Koto KS, Lescault P, Brard L, Kim K, Singh RK, Bond J, Illenye S, Slavik MA, Ashikaga T, Saulnier Sholler GL

International journal of oncology.. 2011 May 38 (5):1329-41. Epub 03/10/2011.

Kim KK, Singh RK, Strongin RM, Moore RG, Brard L, Lange TS

PloS one.. 2011 April 296 (4):e19049. Epub 04/29/2011.

Singh RK, Lange TS, Kim KK, Brard L

Investigational new drugs.. 2011 February 29 (1):63-72. Epub 10/29/2009.

Lange TS, Stuckey AR, Robison K, Kim KK, Singh RK, Raker CA, Brard L

Investigational new drugs.. 2010 October 28 (5):543-53. Epub 07/07/2009.

Lange TS, Zou Y, Singh RK, Kim KK, Kristjansdottir K, Sholler GL, Brard L

Chemical biology & drug design.. 2010 August 76 (2):164-73. Epub 05/11/2010.

Kim KK, Lange TS, Singh RK, Brard L

BMC cancer.. 2010 February 2510 :72. Epub 02/25/2010.

Lange TS, McCourt C, Singh RK, Kim KK, Singh AP, Luisi BS, Alptürk O, Strongin RM, Brard L

Drug design, development and therapy.. 2009 September 213 :17-26. Epub 09/21/2009.

Singh AP, Singh RK, Kim KK, Satyan KS, Nussbaum R, Torres M, Brard L, Vorsa N

Phytotherapy research : PTR.. 2009 August 23 (8):1066-74. Epub 1900 01 01.

Brard L, Singh RK, Kim KK, Lange TS, Sholler GL

Drug design, development and therapy.. 2009 February 62 :61-9. Epub 02/06/2009.

Singh RK, Lange TS, Kim KK, Singh AP, Vorsa N, Brard L

British journal of cancer.. 2008 December 299 (11):1823-31. Epub 11/11/2008.

Lange TS, Kim KK, Singh RK, Strongin RM, McCourt CK, Brard L

PloS one.. 2008 May 283 (5):e2303. Epub 05/28/2008.

Singh RK, Lange TS, Kim KK, Shaw SK, Brard L

Gynecologic oncology.. 2008 May 109 (2):240-9. Epub 03/07/2008.

RKS-2-62: A novel therapy for medulloblastoma with activity in vitro and in vivo.

Koto K, Brard L, Bosenberg M, Singh RK, Kim KK. Scholler GS.

Neurooncology. 2008; 10: 513-514.

Synthesis of Bicyclic Aryl Thiazolines with selective anti-proliferative effects on human cancer cell lines.

Singh RK, Lange TS, Kim KK, Singh AP, Hopson R, Vorsa N, Brard L.

Lett Org Chem. 2008; 5: 103-109.

Singh RK, Lange TS, Kim K, Zou Y, Lieb C, Sholler GL, Brard L

Bioorganic & medicinal chemistry letters.. 2007 November 117 (21):5846-52. Epub 08/19/2007.

Lange TS, Singh RK, Kim KK, Zou Y, Kalkunte SS, Sholler GL, Swamy N, Brard L

Chemical biology & drug design.. 2007 October 70 (4):302-10. Epub 1900 01 01.

A simple and efficient synthesis of 8-methyl-3, 8-diazabicyclo[3.2.1]octane (azatropane) and 3-substituted azatropanes therefrom using pyroglutamic acid.

Singh RK, Jain S, Sinha N, Mehta A, Naqvi F, Agarwal AK and Anand N.

Tet Lett. 2007; 48: 545-548.

Satyan KS, Swamy N, Dizon DS, Singh R, Granai CO, Brard L

Gynecologic oncology.. 2006 October 103 (1):261-70. Epub 04/19/2006.

A general and efficient sythesis of 3,6-diazabicyclo[3.2.1]octanes.

Singh RK, Sinha N, Jain S, Naqvi F, Mehta A.

Tetrahedron. 2006; 62: 4011-4017.

Synthesis of optically active heterocyclic alpha-amino acids from activated lactams.

Singh RK, Sinha N, Jain S, Naqvi F, Salman M. and Anand N.

Part-1. Synthesis. 2005; 16: 2765-2771.

Synthesis of optically active beta-heterocyclic beta-amino acids from activated lactam.

Singh RK, Sinha N, Jain S, Naqvi F, Anand N.

Part-2. Tetrahedron. 2005; 61(37): 8868-8874.