Â鶹ÊÓƵ

Skip to content
Home
Marissa E. Terry, Ph.D.

Marissa E. Terry, Ph.D.

Contact

Office (585) 276-4099

Looking for more Information?

Visit my lab website to learn more about my research, collaborators, latest news, etc.

Visit Research Lab Website

About Me

Faculty Appointments

Assistant Professor - Department of Environmental Medicine (SMD)

Assistant Professor - Department of Neuroscience (SMD) - Joint

Research

Dr. Sobolewski's lab focuses on sex-differentiated mechanisms of neurotoxicity. The perinatal endocrine environment of a developing mammal differs depending on sex. These sex-specific hormone profiles may result in unique sensitivity to endocrine active chemicals (EACs). We test the hypothesis that ...
Dr. Sobolewski's lab focuses on sex-differentiated mechanisms of neurotoxicity. The perinatal endocrine environment of a developing mammal differs depending on sex. These sex-specific hormone profiles may result in unique sensitivity to endocrine active chemicals (EACs). We test the hypothesis that environmental disruption of perinatal hormone profiles results in lasting sex-specific changes to brain development and behavior. The goal is to advance our understanding of differential toxicity risk based on sex. Ultimately, our lab seeks to translate our mechanistic research into a deep understanding of the role the environment plays in the etiology of neurobehavioral disorders with sex-biased prevalence rates, such as Attention Deficit / Hyperactivity Disorder and Autism Spectrum Disorders.
Our first research aim examines EAC disruption of early sex steroids, specifically disruption of the male-specific testosterone surge before and after birth known as the perinatal testosterone surge (PTS). Steroid hormones are key regulators of reproductive tract and central nervous system development. Using EACs, our lab disrupts PTS signaling to elucidate its role in sex-specific nervous system development in rodents. Furthermore, given the vast number of compounds with endocrine disrupting properties, it is critical to characterize combinations of compounds that alter such key developmental pathways. Mixtures studies are significant for public health protection as current methods of risk assessment, based only on effect thresholds of single chemicals, may overestimate the actual no-adverse effect risk levels of EACs.
Our second research aim focuses on mechanisms connecting early hormone disruption with adult behavioral variability. Consistent with fetal origins of adult disease theory, environmental information gathered during development is carried forward into adulthood, influencing behavior. Increasingly, research is identifying that epigenetic modifications may provide the cellular memory for transmission. Our lab uses environmental stressors and endocrine active chemicals to elucidate mechanisms of cellular transmission from development into adulthood through epigenetic reprogramming.

Publications

Journal Articles

Downs CJ, Sobolewski ME

Physiology.. 2024 May 29 Epub 05/29/2024.

Cubello J, Marvin E, Conrad K, Merrill AK, George JV, Welle K, Jackson BP, Chalupa D, Oberdörster G, Sobolewski M, Cory-Slechta DA

Neurotoxicology.. 2024 January 100 :55-71. Epub 12/09/2023.

Merrill AK, Sobolewski M, Susiarjo M

Molecular and cellular endocrinology.. 2023 November 1577 :112031. Epub 07/26/2023.

Cory-Slechta DA, Sobolewski M

Nature reviews. Neuroscience.. 2023 March 24 (3):129-130. Epub 1900 01 01.

Cory-Slechta DA, Merrill A, Sobolewski M

Annual review of pharmacology and toxicology.. 2023 January 2063 :143-163. Epub 08/26/2022.

Sobolewski M, Conrad K, Marvin E, Eckard M, Goeke CM, Merrill AK, Welle K, Jackson BP, Gelein R, Chalupa D, Oberdörster G, Cory-Slechta DA

Particle and fibre toxicology.. 2022 August 919 (1):56. Epub 08/09/2022.

Merrill AK, Conrad K, Marvin E, Sobolewski M

Frontiers in toxicology.. 2022 4 :971970. Epub 08/29/2022.

Merrill AK, Anderson T, Conrad K, Marvin E, James-Todd T, Cory-Slechta DA, Sobolewski M

Toxics.. 2021 December 99 (12)Epub 12/09/2021.

Anderson T, Merrill AK, Eckard ML, Marvin E, Conrad K, Welle K, Oberdörster G, Sobolewski M, Cory-Slechta DA

Toxicological sciences : an official journal of the Society of Toxicology.. 2021 February 26180 (1):175-185. Epub 1900 01 01.

Rand MD, Conrad K, Marvin E, Harvey K, Henderson D, Tawil R, Sobolewski M, Cory-Slechta DA

Neurotoxicology.. 2020 December 81 :1-10. Epub 07/28/2020.

Sobolewski M, Abston K, Conrad K, Marvin E, Harvey K, Susiarjo M, Cory-Slechta DA

Environmental health perspectives.. 2020 February 128 (2):27001. Epub 02/05/2020.

Cory-Slechta DA, Sobolewski M, Marvin E, Conrad K, Merrill A, Anderson T, Jackson BP, Oberdorster G

Toxicologic pathology.. 2019 December 47 (8):976-992. Epub 10/14/2019.

Morris-Schaffer K, Merrill A, Jew K, Wong C, Conrad K, Harvey K, Marvin E, Sobolewski M, Oberdörster G, Elder A, Cory-Slechta DA

Particle and fibre toxicology.. 2019 February 1816 (1):10. Epub 02/18/2019.

Morris-Schaffer K, Merrill AK, Wong C, Jew K, Sobolewski M, Cory-Slechta DA

Particle and fibre toxicology.. 2019 January 716 (1):1. Epub 01/07/2019.

Sobolewski M, Anderson T, Conrad K, Marvin E, Klocke C, Morris-Schaffer K, Allen JL, Cory-Slechta DA

Neurotoxicology.. 2018 September 68 :203-211. Epub 08/23/2018.

Klocke C, Sherina V, Graham UM, Gunderson J, Allen JL, Sobolewski M, Blum JL, Zelikoff JT, Cory-Slechta DA

Inhalation toxicology.. 2018 August 30 (9-10):381-396. Epub 12/20/2018.

Morris-Schaffer K, Sobolewski M, Allen JL, Marvin E, Yee M, Arora M, O'Reilly MA, Cory-Slechta DA

Neurotoxicology.. 2018 July 67 :234-244. Epub 06/18/2018.

Sobolewski M, Varma G, Adams B, Anderson DW, Schneider JS, Cory-Slechta DA

Toxicological sciences : an official journal of the Society of Toxicology.. 2018 June 1163 (2):478-489. Epub 1900 01 01.

Sobolewski M, Conrad K, Marvin E, Allen JL, Cory-Slechta DA

Hormones and behavior.. 2018 May 101 :36-49. Epub 02/01/2018.

Klocke C, Allen JL, Sobolewski M, Blum JL, Zelikoff JT, Cory-Slechta DA

Neurotoxicology.. 2018 March 65 :196-206. Epub 10/24/2017.

Singh G, Singh V, Sobolewski M, Cory-Slechta DA, Schneider JS

Frontiers in genetics.. 2018 9 :89. Epub 03/16/2018.

Sobolewski M, Singh G, Schneider JS, Cory-Slechta DA

Frontiers in integrative neuroscience.. 2018 12 :29. Epub 07/19/2018.

Morris-Schaffer K, Sobolewski M, Welle K, Conrad K, Yee M, O'Reilly MA, Cory-Slechta DA

Neurotoxicology and teratology.. 2018 70 :51-59. Epub 10/11/2018.

Cory-Slechta DA, Sobolewski M, Varma G, Schneider JS

Current opinion in toxicology.. 2017 October 6 :60-70. Epub 09/28/2017.

Sobolewski M, Weiss B, Martin M, Gurven M, Barrett E

International journal of hygiene and environmental health.. 2017 July 220 (5):799-809. Epub 03/27/2017.

Klocke C, Allen JL, Sobolewski M, Mayer-Pröschel M, Blum JL, Lauterstein D, Zelikoff JT, Cory-Slechta DA

Toxicological sciences : an official journal of the Society of Toxicology.. 2017 April 1156 (2):492-508. Epub 1900 01 01.

Schneider JS, Anderson DW, Kidd SK, Sobolewski M, Cory-Slechta DA

Neurotoxicology.. 2016 May 54 :65-71. Epub 03/24/2016.

Sobolewski M, Allen JL, Morris-Schaffer K, Klocke C, Conrad K, Cory-Slechta DA

Neurotoxicology and teratology.. 2016 56 :75-80. Epub 04/14/2016.

Sobolewski M, Conrad K, Allen JL, Weston H, Martin K, Lawrence BP, Cory-Slechta DA

Neurotoxicology.. 2014 December 45 :121-30. Epub 10/22/2014.

Barrett ES, Sobolewski M

Seminars in reproductive medicine.. 2014 May 32 (3):166-76. Epub 04/08/2014.

Weston HI, Sobolewski M, Allen JL, Weston D, Conrad K, Pelkowski S, Watson GE, Zareba G, Cory-Slechta DA

Neurotoxicology.. 2014 March 41 :123-40. Epub 02/03/2014.

Sobolewski ME, Brown JL, Mitani JC

Primates; journal of primatology.. 2013 January 54 (1):81-8. Epub 10/25/2012.