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Whasil Lee, Ph.D.

Whasil Lee, Ph.D.

Contact

Office (585) 276-4631

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About Me

Faculty Appointments

Assistant Professor - Department of Pharmacology and Physiology (SMD) - Joint

Research

The Lee Lab studies the mechanically activated ion channels expressed in knee joint cells to gain fundamental insights into mechanotransduction-related tissue development, maintenance, and degeneration. We investigate the mechanotransduction mechanisms of chondrocytes, synoviocytes, ligament cells, ...
The Lee Lab studies the mechanically activated ion channels expressed in knee joint cells to gain fundamental insights into mechanotransduction-related tissue development, maintenance, and degeneration. We investigate the mechanotransduction mechanisms of chondrocytes, synoviocytes, ligament cells, joint-innervating neurons and chondrogenic stem cells in both physiologic and pathophysiologic conditions. Our overarching goal is to deconstruct the function of key mechanotransducing ion channels of musculoskeletal cells and to and apply this knowledge to find rational therapeutic drugs which can stop the progression of osteoarthritis, stop the arthritis associated pain and/or regenerate healthy cartilage.

Publications

Journal Articles

Jing X, Kotelsky A, Zhang Y, Dirksen R, Mannava S, Buckley M, Lee W

bioRxiv : the preprint server for biology.. 2024 August 6 Epub 08/06/2024.

Wise BC, Mora KE, Lee W, Buckley MR

Journal of visualized experiments : JoVE.. 2023 December 8 (202)Epub 12/08/2023.

Anderson DE, Broun KG, Kundu P, Jing X, Tang X, Lu C, Kotelsky A, Mannava S, Lee W

Frontiers in bioengineering and biotechnology.. 2023 11 :1244975. Epub 09/05/2023.

Fraser D, Nguyen T, Kotelsky A, Lee W, Buckley M, Benoit DSW

ACS biomaterials science & engineering.. 2022 August 88 (8):3568-3575. Epub 07/06/2022.

Kotelsky A, Elahi A, Nejat Yigit C, Proctor A, Mannava S, Pröschel C, Lee W

Osteoarthritis and cartilage open.. 2022 March 4 (1):100227. Epub 12/15/2021.

Gao W, Hasan H, Anderson DE, Lee W

Frontiers in cell and developmental biology.. 2022 10 :885224. Epub 05/04/2022.

Lee W, Nims RJ, Savadipour A, Zhang Q, Leddy HA, Liu F, McNulty AL, Chen Y, Guilak F, Liedtke WB

Proceedings of the National Academy of Sciences of the United States of America.. 2021 March 30118 (13)Epub 1900 01 01.

Kanju P, Chen Y, Lee W, Yeo M, Lee SH, Romac J, Shahid R, Fan P, Gooden DM, Simon SA, Spasojevic I, Mook RA, Liddle RA, Guilak F, Liedtke WB

Scientific reports.. 2016 June 16 :26894. Epub 06/01/2016.

Chen Y, Kanju P, Fang Q, Lee SH, Parekh PK, Lee W, Moore C, Brenner D, Gereau RW, Wang F, Liedtke W

Pain.. 2014 December 155 (12):2662-2672. Epub 10/02/2014.

Lee W, Leddy HA, Chen Y, Lee SH, Zelenski NA, McNulty AL, Wu J, Beicker KN, Coles J, Zauscher S, Grandl J, Sachs F, Guilak F, Liedtke WB

Proceedings of the National Academy of Sciences of the United States of America.. 2014 November 25111 (47):E5114-22. Epub 11/10/2014.

Lee W, Strümpfer J, Bennett V, Schulten K, Marszalek PE

The Journal of biological chemistry.. 2012 June 1287 (23):19115-21. Epub 04/18/2012.

Lee W, Zeng X, Rotolo K, Yang M, Schofield CJ, Bennett V, Yang W, Marszalek PE

Biophysical journal.. 2012 March 7102 (5):1118-26. Epub 03/06/2012.

Lee W, Zeng X, Zhou HX, Bennett V, Yang W, Marszalek PE

The Journal of biological chemistry.. 2010 December 3285 (49):38167-72. Epub 09/24/2010.

Kim M, Abdi K, Lee G, Rabbi M, Lee W, Yang M, Schofield CJ, Bennett V, Marszalek PE

Biophysical journal.. 2010 June 1698 (12):3086-92. Epub 1900 01 01.

Serquera D, Lee W, Settanni G, Marszalek PE, Paci E, Itzhaki LS

Biophysical journal.. 2010 April 798 (7):1294-301. Epub 1900 01 01.

Jiang Y, Rabbi M, Kim M, Ke C, Lee W, Clark RL, Mieczkowski PA, Marszalek PE

Biophysical journal.. 2009 February 96 (3):1151-8. Epub 1900 01 01.

Rivera M, Lee W, Ke C, Marszalek PE, Cole DG, Clark RL

Biophysical journal.. 2008 October 95 (8):3991-8. Epub 07/18/2008.