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Patrick J. Murphy, Ph.D.

Patrick J. Murphy, Ph.D.

Contact

Office (585) 275-0113

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About Me

Faculty Appointments

Associate Professor - Department of Biomedical Genetics (SMD)

Associate Professor - Department of Biology RC (RC) - Joint

Research

The Murphy lab investigates the mechanisms that activate or silence genes as cells transition from one state to another. In very early embryos, stem cells begin to divide and change. Through this process, called differentiation, tissues start to form, and all the cell types of the organism begin to ...
The Murphy lab investigates the mechanisms that activate or silence genes as cells transition from one state to another. In very early embryos, stem cells begin to divide and change. Through this process, called differentiation, tissues start to form, and all the cell types of the organism begin to arise. Differentiation relies on a highly coordinated series of gene activation and silencing events. As cells divide during differentiation, changes in gene expression provide each cell type with a specific identity and function. In a similar sense, when the gene expression patterns of normal adult cells change inappropriately, the cell identity also changes, and this can lead to carcinogenesis. Presently, it is unknown what molecular machinery allows a cell to transition from one gene expression state to another.

Publications

Journal Articles

Duong P, Rodriguez-Parks A, Kang J, Murphy PJ

Epigenetics & chromatin.. 2024 July 2017 (1):22. Epub 07/20/2024.

Reda A, Hategan LA, McLean TAB, Creighton SD, Luo JQ, Chen SES, Hua S, Winston S, Reeves I, Padmanabhan A, Dahi TA, Ramzan F, Brimble MA, Murphy PJ, Walters BJ, Stefanelli G, Zovkic IB

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.. 2024 July 49 (8):1285-1295. Epub 02/16/2024.

Alexander WB, Wang W, Hill MA, O'Dell MR, Ruffolo LI, Guo B, Jackson KM, Ullman N, Friedland SC, McCall MN, Patel A, Figueroa-Guilliani N, Georger M, Belt BA, Whitney-Miller CL, Linehan DC, Murphy PJ, Hezel AF

Disease models & mechanisms.. 2024 June 117 (6)Epub 02/28/2024.

Duong P, Rodriguez-Parks A, Kang J, Murphy PJ

Research square.. 2024 April 3 Epub 04/03/2024.

Blanc R, Shah N, Salama N, Meng F, Mousaei A, Chakkalakal J, Onukwufor J, Murphy P, Calvi L, Dirksen R

Research square.. 2024 March 15 Epub 03/15/2024.

Halblander FN, Meng FW, Murphy PJ

Developmental biology.. 2024 March 507 :34-43. Epub 12/28/2023.

Murphy PJ, Berger F

Development.. 2023 November 1150 (21)Epub 11/03/2023.

Meng FW, Murphy KE, Makowski CE, Delatte B, Murphy PJ

Development.. 2023 November 1150 (21)Epub 11/08/2023.

Chen S, Rosin LF, Pegoraro G, Moshkovich N, Murphy PJ, Yu G, Lei EP

Nucleic acids research.. 2022 August 1250 (14):7906-7924. Epub 1900 01 01.

Akdogan-Ozdilek B, Duval KL, Meng FW, Murphy PJ, Goll MG

Developmental dynamics : an official publication of the American Association of Anatomists.. 2022 April 251 (4):729-742. Epub 10/23/2021.

Hickey GJ, Wike CL, Nie X, Guo Y, Tan M, Murphy PJ, Cairns BR

eLife.. 2022 January 411 Epub 01/04/2022.

Ruff GL, Murphy KE, Smith ZR, Vertino PM, Murphy PJ

BMC cancer.. 2021 December 1821 (1):1342. Epub 12/18/2021.

Stefanelli G, Makowski CE, Brimble MA, Hall M, Reda A, Creighton SD, Leonetti AM, McLean TAB, Zakaria JM, Baumbach J, Greer CB, Davidoff AM, Walters BJ, Murphy PJ, Zovkic IB

Cell reports.. 2021 August 1736 (7):109551. Epub 1900 01 01.

Meng FW, Murphy PJ

Communications biology.. 2021 May 204 (1):626. Epub 05/20/2021.

Murphy KE, Meng FW, Makowski CE, Murphy PJ

Nature communications.. 2020 October 811 (1):5063. Epub 10/08/2020.

Murphy PJ, Guo J, Jenkins TG, James ER, Hoidal JR, Huecksteadt T, Broberg DS, Hotaling JM, Alonso DF, Carrell DT, Cairns BR, Aston KI

PLoS genetics.. 2020 June 16 (6):e1008756. Epub 06/10/2020.

Rougeot J, Chrispijn ND, Aben M, Elurbe DM, Andralojc KM, Murphy PJ, Jansen PWTC, Vermeulen M, Cairns BR, Kamminga LM

Development.. 2019 September 30146 (19)Epub 09/30/2019.

Murphy PJ, Wu SF, James CR, Wike CL, Cairns BR

Cell.. 2018 February 22172 (5):993-1006.e13. Epub 02/15/2018.

Jenkins TG, James ER, Alonso DF, Hoidal JR, Murphy PJ, Hotaling JM, Cairns BR, Carrell DT, Aston KI

Andrology.. 2017 November 5 (6):1089-1099. Epub 09/26/2017.

Guo J, Grow EJ, Yi C, Mlcochova H, Maher GJ, Lindskog C, Murphy PJ, Wike CL, Carrell DT, Goriely A, Hotaling JM, Cairns BR

Cell stem cell.. 2017 October 521 (4):533-546.e6. Epub 1900 01 01.

Murphy PJ, Cairns BR

Methods in cell biology.. 2016 135 :345-59. Epub 06/21/2016.

Murphy PJ, Cipriany BR, Wallin CB, Ju CY, Szeto K, Hagarman JA, Benitez JJ, Craighead HG, Soloway PD

Proceedings of the National Academy of Sciences of the United States of America.. 2013 May 7110 (19):7772-7. Epub 04/22/2013.

Benítez JJ, Topolancik J, Tian HC, Wallin CB, Latulippe DR, Szeto K, Murphy PJ, Cipriany BR, Levy SL, Soloway PD, Craighead HG

Lab on a chip.. 2012 November 2112 (22):4848-54. Epub 1900 01 01.

Cipriany BR, Murphy PJ, Hagarman JA, Cerf A, Latulippe D, Levy SL, Benítez JJ, Tan CP, Topolancik J, Soloway PD, Craighead HG

Proceedings of the National Academy of Sciences of the United States of America.. 2012 May 29109 (22):8477-82. Epub 05/14/2012.

Park YJ, Herman H, Gao Y, Lindroth AM, Hu BY, Murphy PJ, Putnam JR, Soloway PD

PloS one.. 2012 7 (3):e33024. Epub 03/05/2012.

Watanabe T, Tomizawa S, Mitsuya K, Totoki Y, Yamamoto Y, Kuramochi-Miyagawa S, Iida N, Hoki Y, Murphy PJ, Toyoda A, Gotoh K, Hiura H, Arima T, Fujiyama A, Sado T, Shibata T, Nakano T, Lin H, Ichiyanagi K, Soloway PD, Sasaki H

Science.. 2011 May 13332 (6031):848-52. Epub 1900 01 01.

Cipriany BR, Zhao R, Murphy PJ, Levy SL, Tan CP, Craighead HG, Soloway PD

Analytical chemistry.. 2010 March 1582 (6):2480-7. Epub 1900 01 01.

Books

Transgenerational Epigenetics : Evidence and Debate (2014)

Chapter: Epigenetic Changes in the Paternal Germline

Authors: Murphy KE, Murphy PJ, and Carrell DT

Publisher: Oxford: Academic Press 2014