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Cesare Orlandi, Ph.D.

Cesare Orlandi, Ph.D.

he/him

Contact

Office (585) 275-6613

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About Me

Faculty Appointments

Assistant Professor - Department of Pharmacology and Physiology (SMD)

Credentials

Post-doctoral Training & Residency

Postdoctoral Research Associate
Department of Neuroscience; The Scripps Research Institute, Jupiter, FL
PI: Prof. Kirill Martemyanov
New mechanisms regulating G Protein Coupled Receptor (GPCR) signaling by orphan receptors GPR158/GPR179 in complex with R7-RGS proteins in mouse brain and retina. 2011 - 2018

Postdoctoral Research Associate
University of Brescia, Italy
Head Professors: Prof. Sergio Barlati and Prof. Alessandro Barbon
Analysis of the mechanisms that regulate the activity of Adenosine Deaminases Acting on RNA (ADAR), the enzymes responsible for the RNA editing reaction and their effect on glutamate and serotonin neurotransmission. 2010 - 2011

Research

The main focus of the lab research is to investigate the biology of a group of understudied G protein coupled receptors (GPCR) in brain and visual systems. Members of the large GPCR family are involved in the regulation of every aspect of human physiology. Because of their physiological relevance an...
The main focus of the lab research is to investigate the biology of a group of understudied G protein coupled receptors (GPCR) in brain and visual systems. Members of the large GPCR family are involved in the regulation of every aspect of human physiology. Because of their physiological relevance and localization at the plasma membrane GPCRs are ideal targets for drug development. Orphan GPCRs constitute a group of receptors whose endogenous ligands are still unknown. Nonetheless, the identification of disease-causing mutations in patients together with animal studies have established the involvement of orphan GPCRs in essential physiological processes. More broadly, the lab is interested in applying proteomics, biochemistry, microscopy imaging, and pharmacology to understand the role that orphan GPCRs play in shaping behavioral responses as well as the ways in which alterations in these complexes can lead to diseases.

Publications

Journal Articles

Franchini L, Porter JJ, Lueck JD, Orlandi C

bioRxiv : the preprint server for biology.. 2024 July 26 Epub 07/26/2024.

Franchini L, Orlandi C

Molecular pharmacology.. 2024 May 17105 (6):374-385. Epub 05/17/2024.

Alabdali R, Franchini L, Orlandi C

Molecular pharmacology.. 2023 November 104 (5):230-238. Epub 08/11/2023.

Franchini L, Orlandi C

Progress in molecular biology and translational science.. 2023 195 :47-76. Epub 07/13/2022.

Fu W, Franchini L, Orlandi C

Frontiers in neuroscience.. 2022 16 :891544. Epub 06/23/2022.

Watkins LR, Orlandi C

British journal of pharmacology.. 2021 August 178 (15):2963-2975. Epub 05/08/2021.

Cao Y, Wang Y, Dunn HA, Orlandi C, Shultz N, Kamasawa N, Fitzpatrick D, Li W, Zeitz C, Hauswirth W, Martemyanov KA

Proceedings of the National Academy of Sciences of the United States of America.. 2020 September 22117 (38):23914-23924. Epub 09/02/2020.

Watkins LR, Orlandi C

Genes.. 2020 June 2411 (6)Epub 06/24/2020.

Dunn HA, Zucca S, Dao M, Orlandi C, Martemyanov KA

Molecular psychiatry.. 2019 December 24 (12):1902-1919. Epub 09/04/2019.

Dunn HA, Orlandi C, Martemyanov KA

Pharmacological reviews.. 2019 October 71 (4):503-519. Epub 1900 01 01.

Sutton LP, Muntean BS, Ostrovskaya O, Zucca S, Dao M, Orlandi C, Song C, Xie K, Martemyanov KA

PLoS biology.. 2019 October 17 (10):e3000477. Epub 10/10/2019.

Wang D, Stoveken HM, Zucca S, Dao M, Orlandi C, Song C, Masuho I, Johnston C, Opperman KJ, Giles AC, Gill MS, Lundquist EA, Grill B, Martemyanov KA

Science.. 2019 September 20365 (6459):1267-1273. Epub 08/15/2019.

Song C, Orlandi C, Sutton LP, Martemyanov KA

The Journal of biological chemistry.. 2019 August 30294 (35):13145-13157. Epub 07/16/2019.

Orlandi C, Sutton LP, Muntean BS, Song C, Martemyanov KA

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.. 2019 February 44 (3):642-653. Epub 10/11/2018.

Ostrovskaya OI, Orlandi C, Fajardo-Serrano A, Young SM, Lujan R, Martemyanov KA

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2018 November 1438 (46):10002-10015. Epub 10/12/2018.

Condomitti G, Wierda KD, Schroeder A, Rubio SE, Vennekens KM, Orlandi C, Martemyanov KA, Gounko NV, Savas JN, de Wit J

Neuron.. 2018 October 10100 (1):201-215.e9. Epub 10/02/2018.

Orlandi C, Omori Y, Wang Y, Cao Y, Ueno A, Roux MJ, Condomitti G, de Wit J, Kanagawa M, Furukawa T, Martemyanov KA

Cell reports.. 2018 October 225 (1):130-145.e5. Epub 1900 01 01.

Dunn HA, Patil DN, Cao Y, Orlandi C, Martemyanov KA

Proceedings of the National Academy of Sciences of the United States of America.. 2018 May 8115 (19):5022-5027. Epub 04/23/2018.

Sarria I, Cao Y, Wang Y, Ingram NT, Orlandi C, Kamasawa N, Kolesnikov AV, Pahlberg J, Kefalov VJ, Sampath AP, Martemyanov KA

Cell reports.. 2018 March 2722 (13):3562-3573. Epub 1900 01 01.

Sutton LP, Orlandi C, Song C, Oh WC, Muntean BS, Xie K, Filippini A, Xie X, Satterfield R, Yaeger JDW, Renner KJ, Young SM, Xu B, Kwon H, Martemyanov KA

eLife.. 2018 February 87 Epub 02/08/2018.

Xie K, Colgan LA, Dao MT, Muntean BS, Sutton LP, Orlandi C, Boye SL, Boye SE, Shih CC, Li Y, Xu B, Smith RG, Yasuda R, Martemyanov KA

Current biology : CB.. 2016 November 2126 (22):2992-3003. Epub 10/20/2016.

Sutton LP, Ostrovskaya O, Dao M, Xie K, Orlandi C, Smith R, Wee S, Martemyanov KA

Biological psychiatry.. 2016 August 180 (3):235-45. Epub 08/14/2015.

Tayou J, Wang Q, Jang GF, Pronin AN, Orlandi C, Martemyanov KA, Crabb JW, Slepak VZ

The Journal of biological chemistry.. 2016 April 22291 (17):9133-47. Epub 02/19/2016.

Sarria I, Orlandi C, McCall MA, Gregg RG, Martemyanov KA

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2016 March 936 (10):2915-25. Epub 1900 01 01.

Xu Y, Orlandi C, Cao Y, Yang S, Choi CI, Pagadala V, Birnbaumer L, Martemyanov KA, Vardi N

Scientific reports.. 2016 February 176 :20940. Epub 02/17/2016.

Aguado C, Orlandi C, Fajardo-Serrano A, Gil-Minguez M, Martemyanov KA, Luján R

Frontiers in neuroanatomy.. 2016 10 :114. Epub 11/30/2016.

Cao Y, Sarria I, Fehlhaber KE, Kamasawa N, Orlandi C, James KN, Hazen JL, Gardner MR, Farzan M, Lee A, Baker S, Baldwin K, Sampath AP, Martemyanov KA

Neuron.. 2015 September 2387 (6):1248-1260. Epub 1900 01 01.

Orlandi C, Xie K, Masuho I, Fajardo-Serrano A, Lujan R, Martemyanov KA

The Journal of biological chemistry.. 2015 May 29290 (22):13622-39. Epub 03/19/2015.

Orlandi C, Cao Y, Martemyanov KA

Investigative ophthalmology & visual science.. 2013 October 2954 (10):7153-61. Epub 10/29/2013.

La Via L, Bonini D, Russo I, Orlandi C, Barlati S, Barbon A

Nucleic acids research.. 2013 January 741 (1):617-31. Epub 11/19/2012.

Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA

The Journal of cell biology.. 2012 June 11197 (6):711-9. Epub 1900 01 01.

Orlandi C, Barbon A, Barlati S

Molecular neurobiology.. 2012 February 45 (1):61-75. Epub 11/20/2011.

Barbon A, Caracciolo L, Orlandi C, Musazzi L, Mallei A, La Via L, Bonini D, Mora C, Tardito D, Gennarelli M, Racagni G, Popoli M, Barlati S

Neurochemistry international.. 2011 November 59 (6):896-905. Epub 08/03/2011.

Barbon A, Orlandi C, La Via L, Caracciolo L, Tardito D, Musazzi L, Mallei A, Gennarelli M, Racagni G, Popoli M, Barlati S

Neuropsychobiology. 2011 63 (3):160-8. Epub 01/13/2011.

Orlandi C, La Via L, Bonini D, Mora C, Russo I, Barbon A, Barlati S

PloS one.. 2011 6 (9):e25350. Epub 09/22/2011.

Barbon A, Gervasoni A, LaVia L, Orlandi C, Jaskolski F, Perrais D, Barlati S

Neuroscience letters.. 2008 March 21434 (1):77-82. Epub 02/02/2008.

Books

Progress in Molecular Biology and Translational Science (2022)

Chapter: Probing the orphan receptors: Tools and directions

Authors: Luca Franchini Cesare Orlandi

Publisher: Elsevier 2022