Yan Sun, Ph.D.
Contact
Looking for more Information?
Visit my lab website to learn more about my research, collaborators, latest news, etc.
Yan Sun, Ph.D.
About Me
As a PhD student, I have studied the IFN antagonists of one arterivirus...
As a PhD student, I have studied the IFN antagonists of one arterivirus, Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and identified its Nsp1 and Nsp11 suppressing type I IFN production through different mechanisms.
As a postdoc and later a research associate, my research focuses on four major discoveries in regards of RSV DVGs: 1) DVGs generated during RSV infection in vitro trigger the production of type I and III IFN via an IRF1-IRF3 axis. Moreover, DVGs in mice are both immunostimulatory and essential for control of RSV replication, thereby minimizing acute lung pathology; 2) half of the hospitalized RSV infected pediatric patients in our study were DVG positive and DVG levels positively correlated with antiviral gene expression. The kinetics of DVG generated in RSV infected adults affect RSV disease severity; 3) DVGs in Sendai virus (potentially RSV) promote viral persistence by activating a MAVS-mediated response that selectively protects infected cells harboring high levels of cbDVGs from TNF-induced apoptosis; and 4) while current paradigms suggested that DVGs generated during viral replication were formed in random locations due to 鈥渆rrors鈥 of the viral polymerase, I discovered that there are three hotspots within the viral genome for RSV DVG formation and modification of specific nucleotides within at least one of these hotspots can abolish DVGs formation at that location, strongly arguing against the random dogma. In the last project, I, with my collaborators, developed an algorithm to specifically identify RSV DVGs from RNA-seq dataset, equipped my lab with bioinformatic tools for future DVG studies.
Faculty Appointments
Assistant Professor - Department of Microbiology and Immunology (SMD)
Research
Publications
Journal Articles
Felt SA, Sun Y, Jozwik A, Paras A, Habibi MS, Nickle D, Anderson L, Achouri E, Feemster KA, C谩rdenas AM, Turi KN, Chang M, Hartert TV, Sengupta S, Chiu C, L贸pez CB
Nature microbiology.. 2021 May 6 (5):672-681. Epub 04/01/2021.
Sun Y, Kim EJ, Felt SA, Taylor LJ, Agarwal D, Grant GR, L贸pez CB
PLoS pathogens.. 2019 October 15 (10):e1008099. Epub 10/03/2019.
Sun Y, Kim EJ, Felt SA, Taylor LJ, Agarwal D, Grant GR, L贸pez CB
PLoS pathogens.. 2019 April 15 (4):e1007707. Epub 04/17/2019.
Kenney AD, Dowdle JA, Bozzacco L, McMichael TM, St Gelais C, Panfil AR, Sun Y, Schlesinger LS, Anderson MZ, Green PL, L贸pez CB, Rosenberg BR, Wu L, Yount JS
Annual review of genetics. 2017 November 2751 :241-263. Epub 08/30/2017.
Xu J, Sun Y, Li Y, Ruthel G, Weiss SR, Raj A, Beiting D, L贸pez CB
Nature communications.. 2017 October 68 (1):799. Epub 10/06/2017.
Sun Y, L贸pez CB
Vaccine.. 2017 January 1135 (3):481-488. Epub 09/28/2016.
Muallem G, Wagage S, Sun Y, DeLong JH, Valenzuela A, Christian DA, Harms Pritchard G, Fang Q, Buza EL, Jain D, Elloso MM, L贸pez CB, Hunter CA
PLoS pathogens.. 2017 January 13 (1):e1006173. Epub 01/27/2017.
Philip NH, DeLaney A, Peterson LW, Santos-Marrero M, Grier JT, Sun Y, Wynosky-Dolfi MA, Zwack EE, Hu B, Olsen TM, Rongvaux A, Pope SD, L贸pez CB, Oberst A, Beiting DP, Henao-Mejia J, Brodsky IE
PLoS pathogens.. 2016 October 12 (10):e1005910. Epub 10/13/2016.
Sun Y, L贸pez CB
Bio-protocol.. 2016 May 206 (10)Epub 1900 01 01.
Sun Y, L贸pez CB
Bio-protocol.. 2016 May 206 (10)Epub 1900 01 01.
Sun Y, Ke H, Han M, Chen N, Fang W, Yoo D
PloS one.. 2016 11 (12):e0168314. Epub 12/20/2016.
Sun Y, Jain D, Koziol-White CJ, Genoyer E, Gilbert M, Tapia K, Panettieri RA, Hodinka RL, L贸pez CB
PLoS pathogens.. 2015 September 11 (9):e1005122. Epub 09/03/2015.
Sun Y, Li D, Giri S, Prasanth SG, Yoo D
BioMed research international.. 2014 2014 :430508. Epub 02/26/2014.
Mercado-L贸pez X, Cotter CR, Kim WK, Sun Y, Mu帽oz L, Tapia K, L贸pez CB
Vaccine.. 2013 November 1931 (48):5713-21. Epub 10/05/2013.
Tapia K, Kim WK, Sun Y, Mercado-L贸pez X, Dunay E, Wise M, Adu M, L贸pez CB
PLoS pathogens.. 2013 October 9 (10):e1003703. Epub 10/31/2013.
Sun Y, Han M, Kim C, Calvert JG, Yoo D
Viruses.. 2012 April 4 (4):424-46. Epub 04/02/2012.
Yoo D, Song C, Sun Y, Du Y, Kim O, Liu HC
Virus research.. 2010 December 154 (1-2):48-60. Epub 07/23/2010.
Kim O, Sun Y, Lai FW, Song C, Yoo D
Virology.. 2010 July 5402 (2):315-26. Epub 04/22/2010.