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Chike Cao, Ph.D.

Chike Cao, Ph.D.

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About Me

Dr. Chike Cao joined the Center for Musculoskeletal Research, Department of Othoepadics at Â鶹ÊÓƵ in September of 2020. She earned her bachelor’s degree in Biological Education from Huazhong Normal University in China. She received her Master’s degree at University of...
Dr. Chike Cao joined the Center for Musculoskeletal Research, Department of Othoepadics at Â鶹ÊÓƵ in September of 2020. She earned her bachelor’s degree in Biological Education from Huazhong Normal University in China. She received her Master’s degree at University of Arkansas in Dr. Michael Lehmann’s laboratory studying program cell death in Drosophila. She obtained her doctoral degree at New Jersey Medical School, Rutgers University in Dr. Tibor Rohacs’s lab focusing on TRP Ca2+ channel regulation. Dr. Cao worked as a post-doctoral fellow at Mayo Clinic under the mentorship of Dr. Gianrico Farrugia studying Ano1 chloride channel in ICCs and Duke University under the mentorship of Dr. Geoffrey Pitt and Dr. Matthew Hilton investigating CaV1.2 L-type Ca2+ channel for bone formation. She then joined the faculty as an instructor in Dr. Geoffrey Pitt’s lab at Weill Cornell Medicine, collaborating with Dr. Christopher Mendias and Dr. Scott Rodeo to study the function of CaV1.2 in tendon formation.

Faculty Appointments

Assistant Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD)

Assistant Professor - Department of Pharmacology and Physiology (SMD) - Joint

Credentials

Awards

NIH NIAMS R21. 2020

Alice L. Jee Young Investigator Award. 2019

Harold M. Frost Young Investigator Award. 2017

Travel Award. 2016 - 2017

Research

Dr. Cao’s research focuses on understanding the physiological and pathophysiological contribution of CaV1.2 Ca2+ channel, its activation mechanisms and the molecular basis of Ca2+-dependent cellular processes during non-excitable musculoskeletal tissue (such as bone and tendon) development, postnata...
Dr. Cao’s research focuses on understanding the physiological and pathophysiological contribution of CaV1.2 Ca2+ channel, its activation mechanisms and the molecular basis of Ca2+-dependent cellular processes during non-excitable musculoskeletal tissue (such as bone and tendon) development, postnatal growth and their repair/regeneration upon injury. The long-term goal of her research program aims to translate their findings related to Ca2+ channel and Ca2+ signaling in basic bone and tendon biology to clinical trials in patients to help prevent and treat musculoskeletal diseases such as osteoporosis, tendinopathies, and heterotopic ossification in soft tissues. Her approach utilizes genetic mouse models, primary cell culture systems, pharmacological approaches, next-generation sequencing techniques, multiphoton Ca2+ imaging to define the molecular mechanisms and signaling cascades up/downstream of CaV1.2 in bone and tendon formation.

Publications

Journal Articles

Pitt GS, Matsui M, Cao C

Annual review of physiology.. 2021 February 1083 :183-203. Epub 10/26/2020.

Cao C, Oswald AB, Fabella BA, Ren Y, Rodriguiz R, Trainor G, Greenblatt MB, Hilton MJ, Pitt GS

Bone.. 2019 August 125 :160-168. Epub 05/20/2019.

Cao C, Ren Y, Barnett AS, Mirando AJ, Rouse D, Mun SH, Park-Min KH, McNulty AL, Guilak F, Karner CM, Hilton MJ, Pitt GS

JCI insight.. 2017 November 162 (22)Epub 11/16/2017.

Nersesyan Y, Demirkhanyan L, Cabezas-Bratesco D, Oakes V, Kusuda R, Dawson T, Sun X, Cao C, Cohen AM, Chelluboina B, Veeravalli KK, Zimmermann K, Domene C, Brauchi S, Zakharian E

Cell reports.. 2017 November 721 (6):1681-1691. Epub 1900 01 01.

Malysz J, Gibbons SJ, Saravanaperumal SA, Du P, Eisenman ST, Cao C, Oh U, Saur D, Klein S, Ordog T, Farrugia G

American journal of physiology. Gastrointestinal and liver physiology.. 2017 March 1312 (3):G228-G245. Epub 12/15/2016.

Singh RD, Gibbons SJ, Saravanaperumal SA, Du P, Hennig GW, Eisenman ST, Mazzone A, Hayashi Y, Cao C, Stoltz GJ, Ordog T, Rock JR, Harfe BD, Szurszewski JH, Farrugia G

The Journal of physiology.. 2014 September 15592 (18):4051-68. Epub 07/25/2014.

Cao C, Yudin Y, Bikard Y, Chen W, Liu T, Li H, Jendrossek D, Cohen A, Pavlov E, Rohacs T, Zakharian E

Cell reports.. 2013 July 254 (2):302-315. Epub 07/11/2013.

Cao C, Zakharian E, Borbiro I, Rohacs T

The Journal of biological chemistry.. 2013 February 22288 (8):5278-90. Epub 01/08/2013.

Yudin Y, Lukacs V, Cao C, Rohacs T

The Journal of physiology.. 2011 December 15589 (Pt 24):6007-27. Epub 10/17/2011.

Zakharian E, Cao C, Rohacs T

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2011 November 25 (11):3915-28. Epub 08/02/2011.

Zakharian E, Cao C, Rohacs T

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2010 September 1530 (37):12526-34. Epub 1900 01 01.

Canal CE, Mahautmr KC, Cao C, Sanders-Bush E, Airey DC

Journal of neurochemistry.. 2009 March 108 (5):1136-42. Epub 01/20/2009.

Cao C, Liu Y, Lehmann M

The Journal of cell biology.. 2007 March 12176 (6):843-52. Epub 03/05/2007.

Mo XY, Cao CK, Xu FH, Liu MY, Li MX, Qin YJ, Zhou Q, Zhang YY, Deng HW

Journal of bone and mineral metabolism.. 2004 22 (3):264-9. Epub 1900 01 01.