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Shu-Chi Yeh, Ph.D.

Shu-Chi Yeh, Ph.D.

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About Me

Dr. Yeh earned her Ph.D. in Biomedical Engineering at McMaster University in 2015. Her Ph.D. research in Dr. Qiyin Fang’s laboratory was dedicated to developing machine learning and optical imaging techniques for automatic detection and treatment optimization in Barrett’s Esophagus cellular models. ...
Dr. Yeh earned her Ph.D. in Biomedical Engineering at McMaster University in 2015. Her Ph.D. research in Dr. Qiyin Fang’s laboratory was dedicated to developing machine learning and optical imaging techniques for automatic detection and treatment optimization in Barrett’s Esophagus cellular models. She started the first postdoctoral training in Prof. Giuseppe Intini’s lab at Harvard School of Dental Medicine, and since then, she has been engaged in advancing intravital imaging technologies for studying bone and hematopoietic stem cells. She developed quantitative 3D bone histomorphometry in vivo to track skeletal stem cells for their roles in craniosynostosis and bone regeneration. Her work was recognized by the Dean’s Scholar Award and Outstanding Postdoctoral Award during the two-year fellowship. She then joined Dr. Charles Lin’s laboratory in the Wellman Center for Photomedicine, Massachusetts General Hospital in 2017. In collaboration with Prof. Fernando Camargo at Boston Children’s Hospital, she developed intravital microscopy techniques to investigate bone remodeling and discovered heterogeneous bone turnover that is critical to focal expansion of hematopoietic stem cells (HSCs) and acute myeloid leukemic cells. These findings led to some insightful follow-up investigations to understand the interplay between bone and the hematopoietic compartments, including the development of the first cell-resolution, quantitative calcium imaging for the bone marrow that uncovered varied extracellular calcium tied to bone remodeling and a high calcium ion concentration neighboring primitive HSCs. In Dr. Lin’s group, she has also participated in the research project using two-photon image-guided microbiopsy and orthotopic injection of cell clusters out of or into the bone marrow, a technology developed by Dr. Lin’s lab to allow spatially resolved transcriptomic profiling of the local bone marrow microenvironment. Her proposal to profile the vascular niche in multiple myeloma was recognized by receiving a Fund for Medical Discovery from MGH. She was later promoted to instructor in Harvard Medical School in 2020.

Faculty Appointments

Assistant Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD)

Assistant Professor - Department of Biomedical Engineering (SMD) - Joint

Assistant Professor - Department of Pharmacology and Physiology (SMD) - Joint

Credentials

Awards

Merit Abstract and Travel Award. 2020

Fund for Medical Discovery Award. 2018 - 2019

Outstanding Postdoctoral Award. 2017

Dean's Scholar Award. 2015 - 2017

NSERC Michael Smith Foreign Study Supplement. 2014

NSERC Alexander Graham Bell CGS-D. 2012 - 2014

Ontario Graduate Scholarship. 2011 - 2012

Queen Elizabeth II Graduate Scholarship in Science and Technology. 2010 - 2011

NSERC Alexander Graham Bell CGS-M. 2009 - 2010

Research

Bone marrow houses hematopoietic stem cells (HSCs) and is also the shelter of hematological malignancies. While bone is a major counterpart in the bone marrow microenvironment, how the two works in concert as a niche, a specialized microenvironment where the stem cells reside, to instruct the fate o...
Bone marrow houses hematopoietic stem cells (HSCs) and is also the shelter of hematological malignancies. While bone is a major counterpart in the bone marrow microenvironment, how the two works in concert as a niche, a specialized microenvironment where the stem cells reside, to instruct the fate of HSCs and malignant cells remains to be elucidated. Dr. Yeh’s major research interest is to develop intravital imaging-based approaches for direct visualization, quantifications, and molecular profiling of the local regulatory machineries that harbor the skeletal, hematopoietic, and malignant stem cells. The long-term goal is to identify distinct pathways in the bone marrow microenvironment that can be targeted to confront hematopoietic malignancy and aging.

Publications

Journal Articles

Lee K, Dissanayake W, MacLiesh M, Hong CL, Yin Z, Kawano Y, Kaszuba CM, Kawano H, Quarato ER, Marples B, Becker M, Bajaj J, Calvi LM, Yeh SA

Scientific reports.. 2024 September 314 (1):20486. Epub 09/03/2024.

Xie C, Ren Y, Weeks J, Rainbolt J, Mark Kenney H, Xue T, Allen F, Shu Y, Tay AJH, Lekkala S, Yeh SA, Muthukrishnan G, Gill AL, Gill SR, Kim M, Kates SL, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2024 March 42 (3):531-538. Epub 10/17/2023.

Lekkala S, Ren Y, Weeks J, Lee K, Tay AJH, Liu B, Xue T, Rainbolt J, Xie C, Schwarz EM, Yeh SA

PloS one.. 2024 19 (6):e0296140. Epub 06/20/2024.

Aldawood ZA, Mancinelli L, Geng X, Yeh SA, Di Carlo R, C Leite T, Gustafson J, Wilk K, Yozgatian J, Garakani S, Bassir SH, Cunningham ML, Lin CP, Intini G

Proceedings of the National Academy of Sciences of the United States of America.. 2023 April 18120 (16):e2120826120. Epub 04/11/2023.

Zhang H, Liesveld JL, Calvi LM, Lipe BC, Xing L, Becker MW, Schwarz EM, Yeh SA

Bone research.. 2023 March 1411 (1):15. Epub 03/14/2023.

Haase C, Gustafsson K, Mei S, Yeh SC, Richter D, Milosevic J, Turcotte R, Kharchenko PV, Sykes DB, Scadden DT, Lin CP

Nature methods.. 2022 December 19 (12):1622-1633. Epub 11/24/2022.

Yeh SA, Hou J, Wu JW, Yu S, Zhang Y, Belfield KD, Camargo FD, Lin CP

Nature communications.. 2022 March 1713 (1):1563. Epub 03/17/2022.

Yeh SA, Hou J, Wu JW, Yu S, Zhang Y, Belfield KD, Camargo FD, Lin CP

Nature communications.. 2022 January 1913 (1):393. Epub 01/19/2022.

Wu JW, Jung Y, Yeh SA, Seo Y, Runnels JM, Burns CS, Mizoguchi T, Ito K, Spencer JA, Lin CP

PloS one.. 2021 16 (8):e0255204. Epub 08/05/2021.

Wright ME, Yu JK, Jain D, Maeda A, Yeh SA, DaCosta RS, Lin CP, Santerre JP

Biomaterials.. 2020 October 256 :120183. Epub 06/23/2020.

Christodoulou C, Spencer JA, Yeh SA, Turcotte R, Kokkaliaris KD, Panero R, Ramos A, Guo G, Seyedhassantehrani N, Esipova TV, Vinogradov SA, Rudzinskas S, Zhang Y, Perkins AS, Orkin SH, Calogero RA, Schroeder T, Lin CP, Camargo FD

Nature.. 2020 February 578 (7794):278-283. Epub 02/05/2020.

Nie Z, Yeh SA, LePalud M, Badr F, Tse F, Armstrong D, Liu LWC, Deen MJ, Fang Q

Frontiers in physiology.. 2020 11 :339. Epub 05/13/2020.

Bassir SH, Garakani S, Wilk K, Aldawood ZA, Hou J, Yeh SA, Sfeir C, Lin CP, Intini G

Frontiers in physiology.. 2019 10 :591. Epub 05/22/2019.

Yeh SA, Wilk K, Lin CP, Intini G

Scientific reports.. 2018 April 38 (1):5580. Epub 04/03/2018.

Wilk K, Yeh SA, Mortensen LJ, Ghaffarigarakani S, Lombardo CM, Bassir SH, Aldawood ZA, Lin CP, Intini G

Stem cell reports.. 2017 April 118 (4):933-946. Epub 03/30/2017.

Tokarz D, Cisek R, Wein MN, Turcotte R, Haase C, Yeh SA, Bharadwaj S, Raphael AP, Paudel H, Alt C, Liu TM, Kronenberg HM, Lin CP

PloS one.. 2017 12 (10):e0186846. Epub 10/24/2017.

Yeh SC, Sahli S, Andrews DW, Patterson MS, Armstrong D, Provias J, Fang Q

Journal of biomedical optics.. 2015 March 20 (3):036010. Epub 1900 01 01.

Yeh SC, Ling CS, Andrews DW, Patterson MS, Diamond KR, Hayward JE, Armstrong D, Fang Q

Journal of biomedical optics.. 2015 February 20 (2):28002. Epub 1900 01 01.

Yeh SC, Diamond KR, Patterson MS, Nie Z, Hayward JE, Fang Q

Theranostics.. 2012 2 (9):817-26. Epub 09/05/2012.

Leung RW, Yeh SC, Fang Q

Biomedical optics express.. 2011 September 12 (9):2517-31. Epub 08/02/2011.