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Camillo Peracchia, M.D.

Camillo Peracchia, M.D.

Contact

Office (585) 275-2201

About Me

Baccalaureate, Liceo Classico, "Istituto Zaccaria" (Milan, Italy), 1956
University of Milan, Milan, Italy, Doctor in Medicine and Surgery (M.D.), 1962
Istituto Provinçial de Obstetricia y Gynecologia, Madrid, Spain, Obstetrics and Gynecology, July 1961
University of Milan, Italy , Surgical ...
Baccalaureate, Liceo Classico, "Istituto Zaccaria" (Milan, Italy), 1956
University of Milan, Milan, Italy, Doctor in Medicine and Surgery (M.D.), 1962
Istituto Provinçial de Obstetricia y Gynecologia, Madrid, Spain, Obstetrics and Gynecology, July 1961
University of Milan, Italy , Surgical Resident, Surgery, 1962-1964
University of Milan, Italy, Postdoctoral Fellow, Pharmacology, 1962-1966
Hopital Broussais, Paris, France, Visiting Surgeon, Cardiac Surgery, July 1965
McLean Hospital, (Harvard), Boston, MA, Research Fellow, Biophysics, 1966-1967
Harvard Medical School, Research Fellow, Neuropathology, 1966-1967
Duke University, Durham, NC, Research Associate, Anatomy, 1967-1970
Educational Council for Medical Graduates (ECFMG) Certificate Number 098-006, 1967

Faculty Appointments

Professor Emeritus - Department of Pharmacology and Physiology (SMD)

Credentials

Post-doctoral Training & Residency

Research Associate. Dept. of Anatomy. Duke University, Durham, NC. 1967 - 1970

Research Fellow. Biophysics. McLean Hospital. Harvard Medical School, Boston, MA 1966 - 1967

Research Fellow. Neuropathology. Harvard Medical School. Boston. Mass. 1966 - 1967

Visiting Surgeon. Cardiac Surgery. Hopital Broussais. Paris, France.

Surgical Resident. University of Milan, Italy 1962 - 1964

Postdoctoral Fellow. Inst. of Pharmacology. University of Milan, Italy. 1962 - 1966

Education

MD | Italy-Fac Med U Milan. Medicine. 1962

Diploma di Maturita', Liceo Classico (Baccalaureate) | Insituto Zaccaria. 1956

Awards

Commendation for Excellence in First Year Medical School Teaching 2005

Adolph Medal for Excellence in Physiology 2004

Commendation for Excellence in First Year Medical School Teaching 2002

Commendation for Excellence in First Year Medical School Teaching 1999

Manuel D. Goldman Prize for Excellence in First-Year 1998

Commendation for Excellence in First Year Medical School Teaching 1996

Commendation for Excellence in First Year Medical School Teaching 1995

Elected Honorary Member of the Societá di Medicina e Scienze Naturali di Parma. Universitá di Parma, Italy. 1987

Research

Our research has focused for several decades on the molecular mechanisms that regulate the permeability of gap junction channels. These channels mediate direct cell-to-cell exchange of small cytosolic molecules. Cell communication via gap junction channels is becoming an area of research increasingl...
Our research has focused for several decades on the molecular mechanisms that regulate the permeability of gap junction channels. These channels mediate direct cell-to-cell exchange of small cytosolic molecules. Cell communication via gap junction channels is becoming an area of research increasingly relevant to clinical medicine. Altered cell-cell communication resulting from mutations of gap junction channel proteins (connexins), plays a key role in the X-linked Charcot-Marie-Tooth demyelinating peripheral neuropathy, hereditary non-syndromic deafness, hereditary skin disorders, and certain forms of hereditary cataract, and may be involved in the pathogenesis of cardiac arrhythmias and cancer. Recently, we have demonstrated a functional interplay between the cystic fibrosis transmembrane conductance regulator chloride channel (CFTR) and various connexin channels. The mechanism of channel regulation and gating has been studied in paired Xenopus oocytes by dual voltage-clamp electrophysiology. The molecular domains that participate in channel gating have been studied by combining molecular genetics and biophysics. The participation of calmodulin in channel gating has been suggested by data generated in oocyte pairs expressing calmodulin and connexin mutants.

Publications

Journal Articles

Peracchia C

International journal of molecular sciences.. 2020 January 1221 (2)Epub 01/12/2020.

The Ca-calmodulin-cork model for chemical gating of gap junction channels

Peracchia, C.

International journal of molecular sciences. 2020; In preparation.

Chemical and voltage gating of gap junction channels expressed in Xenopus oocyte pairs

Peracchia, C.

Springer Nature. 2020; .

Ca2+-dependent and -independent interaction of calmodulin with gap junction cytoplasmic loop peptides

Kerruth, S.; Coates, C.; Rezavi, SA; Peracchia, C.; Török, K.

Biochemical Journal. 2020; .

Calmodulin association with connexin32-derived peptides suggests trans-domain interaction in chemical gating of gap junction channels

Dodd, R; Peracchia, C; Stolady, D; Török, K.

J. Biol. Chem. 2008; : 283:26911-26920.

Peracchia C, Salim M, Peracchia LL

The Journal of membrane biology.. 2007 February 215 (2-3):161-8. Epub 06/14/2007.

Peracchia C, Peracchia LL

American journal of physiology. Cell physiology.. 2005 June 288 (6):C1381-9. Epub 01/26/2005.

Kotsias BA, Peracchia C

The Journal of membrane biology.. 2005 February 203 (3):143-50. Epub 1900 01 01.

Young KC, Peracchia C

The Journal of membrane biology.. 2004 December 202 (3):161-70. Epub 1900 01 01.

Peracchia C, Chen JT, Peracchia LL

The Journal of membrane biology.. 2004 July 15200 (2):105-13. Epub 1900 01 01.

Peracchia C

Biochimica et biophysica acta.. 2004 March 231662 (1-2):61-80. Epub 1900 01 01.

Peracchia C, Young KC, Wang XG, Peracchia LL

The Journal of membrane biology.. 2003 September 1195 (1):53-62. Epub 1900 01 01.

Peracchia C, Young KC, Wang XG, Chen JT, Peracchia LL

Cell communication & adhesion. 2003 10 (4-6):233-7. Epub 1900 01 01.

Sotkis A, Wang XG, Yasumura T, Peracchia LL, Persechini A, Rash JE, Peracchia C

Cell communication & adhesion. 2001 8 (4-6):277-81. Epub 1900 01 01.

Peracchia C, Wang XG, Peracchia LL

The Journal of membrane biology.. 2000 November 1178 (1):55-70. Epub 1900 01 01.

Peracchia C, Sotkis A, Wang XG, Peracchia LL, Persechini A

The Journal of biological chemistry.. 2000 August 25275 (34):26220-4. Epub 1900 01 01.

Peracchia C, Wang XG, Peracchia LL

Methods : a companion to Methods in enzymology.. 2000 February 20 (2):188-95. Epub 1900 01 01.

Peracchia C, Wang XG, Peracchia LL

The American journal of physiology.. 1999 June 276 (6):C1361-73. Epub 1900 01 01.

Wang XG, Peracchia C

The American journal of physiology.. 1998 November 275 (5):C1384-90. Epub 1900 01 01.

Wang XG, Peracchia C

The Journal of membrane biology.. 1998 March 15162 (2):169-76. Epub 1900 01 01.

Wang XG, Peracchia C

Biophysical journal.. 1997 August 73 (2):798-806. Epub 1900 01 01.

Bukauskas FF, Peracchia C

Biophysical journal.. 1997 May 72 (5):2137-42. Epub 1900 01 01.

Peracchia C, Wang XC

Brazilian journal of medical and biological research = Revista brasileira de pesquisas me?dicas e biolo?gicas. 1997 May 30 (5):577-90. Epub 1900 01 01.

Connexin domains relevant to chemical gating of gap junction channels

Peracchia, C. and X.G. Wang.

Brazilian J. Med. Biol. Res. 1997; 30: 577-590.

Molecular basis of gap junction channel regulation and gating

Peracchia, C., X.G. Wang and L.L. Peracchia.

Neurophysiology (Kiev). 1997; 29: 273-279.

Wang XG, Peracchia C

The American journal of physiology.. 1996 November 271 (5 Pt 1):C1743-9. Epub 1900 01 01.

Li H, Liu TF, Lazrak A, Peracchia C, Goldberg GS, Lampe PD, Johnson RG

The Journal of cell biology.. 1996 August 134 (4):1019-30. Epub 1900 01 01.

Wang X, Li L, Peracchia LL, Peracchia C

Pflu?gers Archiv : European journal of physiology.. 1996 April 431 (6):844-52. Epub 1900 01 01.

Peracchia C, Wang X, Li L, Peracchia LL

Pflu?gers Archiv : European journal of physiology.. 1996 January 431 (3):379-87. Epub 1900 01 01.

Lazrak A, Peres A, Giovannardi S, Peracchia C

Biophysical journal.. 1994 September 67 (3):1052-9. Epub 1900 01 01.

Lazrak A, Peracchia C

Biophysical journal.. 1993 November 65 (5):2002-12. Epub 1900 01 01.

Shen L, Shrager P, Girsch SJ, Donaldson PJ, Peracchia C

The Journal of membrane biology.. 1991 October 124 (1):21-32. Epub 1900 01 01.

Girsch SJ, Peracchia C

Current eye research.. 1991 September 10 (9):839-49. Epub 1900 01 01.

Peracchia C

The Journal of membrane biology.. 1991 April 121 (1):67-78. Epub 1900 01 01.

Peracchia C

The Journal of membrane biology.. 1990 July 117 (1):79-89. Epub 1900 01 01.

Peracchia C

The Journal of membrane biology.. 1990 January 113 (1):75-92. Epub 1900 01 01.

Peracchia C, Girsch SJ

Lens and eye toxicity research.. 1989 6 (4):613-21. Epub 1900 01 01.

Taylor KA, Mullner N, Pikula S, Dux L, Peracchia C, Varga S, Martonosi A

The Journal of biological chemistry.. 1988 April 15263 (11):5287-94. Epub 1900 01 01.

Lu KS, Peracchia C

Proceedings of the National Science Council, Republic of China. Part B, Life sciences.. 1987 July 11 (3):289-96. Epub 1900 01 01.

Peracchia C

Pflu?gers Archiv : European journal of physiology.. 1987 April 408 (4):379-85. Epub 1900 01 01.

Peracchia C, Girsch SJ

Biochemical and biophysical research communications.. 1985 December 17133 (2):688-95. Epub 1900 01 01.

Peracchia C, Girsch SJ, Bernardini G, Peracchia LL

Current eye research.. 1985 November 4 (11):1155-69. Epub 1900 01 01.

Peracchia C, Girsch SJ

The American journal of physiology.. 1985 June 248 (6 Pt 2):H765-82. Epub 1900 01 01.

Peracchia C, Girsch SJ

Current eye research.. 1985 April 4 (4):431-9. Epub 1900 01 01.

Peracchia C, Peracchia LL

European journal of cell biology.. 1985 March 36 (2):286-93. Epub 1900 01 01.

Martonosi A, Kracke G, Taylor KA, Dux L, Peracchia C

Society of General Physiologists series. 1985 39 :57-85. Epub 1900 01 01.

Girsch SJ, Peracchia C

The Journal of membrane biology.. 1985 83 (3):217-25. Epub 1900 01 01.

Girsch SJ, Peracchia C

The Journal of membrane biology.. 1985 83 (3):227-33. Epub 1900 01 01.

Peracchia C, Bernardini G

Federation proceedings.. 1984 September 43 (12):2681-91. Epub 1900 01 01.

Peracchia C, Dux L, Martonosi AN

Journal of muscle research and cell motility.. 1984 August 5 (4):431-42. Epub 1900 01 01.

Bernardini G, Peracchia C, Peracchia LL

European journal of cell biology.. 1984 July 34 (2):307-12. Epub 1900 01 01.

The crystallization of Ca2+ transport ATPase in sarcoplasmic reticulum

Martonosi, A.N., L. Dux, C. Peracchia, and K.A. Taylor.

Symp. Biologica, Hungarica. 1984; 26.: 133-151.

Peracchia C

The Journal of membrane biology.. 1984 81 (1):49-58. Epub 1900 01 01.

Peracchia C, Bernardini G, Peracchia LL

Pflu?gers Archiv : European journal of physiology.. 1983 October 399 (2):152-4. Epub 1900 01 01.

Shrager P, Starkus JC, Lo MV, Peracchia C

The Journal of general physiology.. 1983 August 82 (2):221-44. Epub 1900 01 01.

Eastwood AB, Franzini-Armstrong C, Peracchia C

Journal of muscle research and cell motility.. 1982 September 3 (3):273-94. Epub 1900 01 01.

Bernardini G, Peracchia C, Venosa RA

The Journal of physiology.. 1981 November 320 :187-92. Epub 1900 01 01.

Bernardini G, Peracchia C

Investigative ophthalmology & visual science.. 1981 August 21 (2):291-9. Epub 1900 01 01.

Peracchia C

Nature.. 1981 April 16290 (5807):597-8. Epub 1900 01 01.

Peracchia C, Peracchia LL

The Journal of cell biology.. 1980 December 87 (3 Pt 1):708-18. Epub 1900 01 01.

Peracchia C, Peracchia LL

The Journal of cell biology.. 1980 December 87 (3 Pt 1):719-27. Epub 1900 01 01.

Peracchia C

International review of cytology.. 1980 66 :81-146. Epub 1900 01 01.

Peracchia C

Nature.. 1978 February 16271 (5646):669-71. Epub 1900 01 01.

The cell on the move. Comments on the book: "Progress in Clinical and Biological Research". Vol. 17. Cell shape and surface architecture. J.-P. Revel, U. Henning and C. F. Fox, eds.

Peracchia, C.

TIBS (Trends in Biochemical Science). 1978; 3: 216.

Peracchia C

The Journal of cell biology.. 1977 March 72 (3):628-41. Epub 1900 01 01.

Gap junction structure and function

Peracchia, C.

TIBS (Trends in Biochemical Science). 1977; 2: 26-30.

Peracchia C, Dulhunty AF

The Journal of cell biology.. 1976 August 70 (2 pt 1):419-39. Epub 1900 01 01.

Schnapp B, Peracchia C, Mugnaini E

Neuroscience.. 1976 June 1 (3):181-90. Epub 1900 01 01.

Peracchia C

The Journal of cell biology.. 1974 April 61 (1):107-22. Epub 1900 01 01.

Peracchia C

The Journal of cell biology.. 1973 April 57 (1):54-65. Epub 1900 01 01.

Peracchia C

The Journal of cell biology.. 1973 April 57 (1):66-76. Epub 1900 01 01.

Peracchia C, Mittler BS

The Journal of cell biology.. 1972 April 53 (1):234-8. Epub 1900 01 01.

Peracchia C, Mittler BS

Journal of ultrastructure research.. 1972 April 39 (1):57-64. Epub 1900 01 01.

Peracchia C, Robertson JD

The Journal of cell biology.. 1971 October 51 (1):223-39. Epub 1900 01 01.

Peracchia C

The Journal of cell biology.. 1970 January 44 (1):125-33. Epub 1900 01 01.

Peracchia C

Pathologie et biologie. 1967 February 15 (3):132-40. Epub 1900 01 01.

Peracchia C, Vassallo C

Angiology.. 1966 July 17 (7):451-9. Epub 1900 01 01.

Peracchia C

Laboratory investigation; a journal of technical methods and pathology.. 1966 February 15 (2):479-91. Epub 1900 01 01.

Peracchia C, Meldolesi J, Pelosi G

Lo sperimentale. 1966 116 (3):169-89. Epub 1900 01 01.

Clementi F, Nidiry J, Peracchia C

Minerva cardioangiologica.. 1965 October 13 (10):669-77. Epub 1900 01 01.

Clementi F, Peracchia C, Vassallo C

Archivio italiano di anatomia e di embriologia. Italian journal of

CLEMENTI F, PERACCHIA C, VASSALLO C

La Presse médicale.. 1965 February 2473 :537-42. Epub 1900 01 01.

PERACCHIA C

Atti della Accademia medica lombarda. 1964 19 :371-7. Epub 1900 01 01.

ORNESI A, PERACCHIA C, PELOSI G, MELDOLESI J, NIDIRI J

Atti della Accademia medica lombarda. 1964 19 :505-16. Epub 1900 01 01.

Books

Gap Junction Structure and Chemical Regulation (2019)

Chapter: Calmodulin Role in Cell-to-Cell Channel Gating.

Authors: Peracchia, C

Publisher: Academic Press – An imprint of Elsevier 2019

Lung Function in Health and Disease (2014)

Chapter: Basic Concepts of Respiratory Physiology and Pathophysiology

Authors: Peracchia, C.; Anaizi, NH

Publisher: Bentham Science Publishers 2014

Molecular Basis of Cell Communication in Health and Disease (2000)

Authors: Peracchia, C.

Publisher: Academic Press, Inc., San Diego, CA. 2000

Gap Junctions - Molecular Basis of Cell Communication in Health and Disease (2000)

Chapter: Behavior of chemical and slow voltage-gates of connexin channels. The cork gating hypothesis

Authors: Peracchia, C.; Wang, X.G.; Peracchia, L.M.

Publisher: Academic Press, San Diego, CA 2000

Gap Junctions. Molecular Basis of cell Communication in Health and Disease (2000)

Chapter: Distinct behaviors of chemical and voltage sensitive gates of gap junction channels

Authors: Bukauskas, F.F.; Peracchia, C.

Publisher: Academic Press, San Diego, CA 2000

Un Amarcord per un Uomo Eccezionale: il Prof. Emilio Trabucchi (1999)

Chapter: I primi passi del laboratorio di microscopia elettronica da Trabucchi a Milano

Authors: Peracchia, C.

Publisher: Progetto Editoriale Milano Media, Milan, Italy 1999

Gap Junctions (1998)

Chapter: Gating properties of gap junction channels on Schwann cells and fibroblasts isolated from the sciatic nerve of neonatal rats

Authors: Bukauskas, F.; Shrager, P.; Peracchia, C.

Publisher: IOS Press, Amsterdam, The Netherlands 1998

Gap Junctions (1998)

Chapter: Domains of connexin32 relevant to CO2-induced channel gating

Authors: Wang, X.G.; Peracchia, C.

Publisher: IOS Press, Amsterdam, The Netherlands 1998

Progress in Cell Research. (1995)

Chapter: Nanomolar calcium mediates gap junction gating by low pH in Novikoff cells

Authors: Lazrak, A.; Peracchia, C.

Publisher: Elsevier Science, Amsterdam, The Netherlands 1995

Intercellular Communication through Gap Junctions (1995)

Chapter: Calcium participation in ATP and arachidonic acid but not in oleic acid and halothane induced gating of gap junctions in Novikoff cells

Authors: Lazrak, A.; Peres, A.; Giovannardi, S.; Peracchia, C.

Publisher: Elsevier Science, Amsterdam, The Netherlands 1995

Handbook of Membrane Channels. Molecular and Cellular Physiology (1994)

Authors: Peracchia, C.

Publisher: Academic Press, Inc., San Diego, CA 1994

Handbook of Membrane Channels. Molecular and Cellular Physiology (1994)

Chapter: Molecular models of channel interaction and gating in gap junctions

Authors: Peracchia, C., A. Lazrak and L.L. Peracchia

Publisher: Academic Press, Inc., San Diego, CA 1994

Gap Junctions (1993)

Chapter: Gap junction channel reconstitution in artificial bilayers and evidence for calmodulin binding sites in MIP26 and connexins from heart, liver and Xenopus embryo

Authors: Peracchia, C, and L. Shen

Publisher: Elsevier Science, Amsterdam, The Netherlands 1993

Biophysics of Gap Junction Channels (1991)

Authors: Peracchia, C.

Publisher: CRC Press, Inc., Boca Raton, FL 1991

Biophysics of Gap Junction Channels (1991)

Chapter: Role of calcium and calcium stores in gap junction regulation by low pHi

Authors: Peracchia, C.

Publisher: CRC Press, Boca Raton, FL 1991

Cell Interactions and Gap Junctions (1989)

Chapter: Control of gap junction permeability and calmodulin-like proteins

Authors: Peracchia, C.

Publisher: CRC Press, Inc., Boca Raton, FL 1989

"Gap Junctions", Modern Cell Biology Series (1988)

Chapter: The Calmodulin hypothesis for gap junction regulation six years later

Authors: Peracchia, C.

Publisher: Alan R. Liss, Inc., New York 1988

Cell-to-cell Communication (1987)

Chapter: Permeability and regulation of gap junction channels in cells and in artificial lipid bilayers

Authors: Peracchia, C.

Publisher: Plenum Publishing Corp. 1987

The Lens: Transparency and Cataract (1986)

Chapter: Function of lens gap junction channels incorporated into liposomes

Authors: Peracchia, C. and S.J. Girsch

Publisher: EURAGE, UK 1986

The Enzymes of Biological Membranes, 2nd edition (1985)

Chapter: Cell Coupling

Authors: Peracchia, C.

Publisher: Plenum Publishing Corp., New York 1985

Gap Junctions (1985)

Chapter: An in vitro approach to cell coupling: Permeability and gating of gap junction channels incorporated into liposomes

Authors: Peracchia, C. and S.J. Girsch

Publisher: Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 1985

Regulation and Development of Membrane Transport Processes (1984)

Chapter: The regulation of the Ca2+ transport activity of sarcoplasmic reticulum

Authors: Martonosi, A. N., K.A. Taylor, G. Knacke, L. Dux, and C. Peracchia, C.

Publisher: Wiley & Sons, San Francisco Press 1984

42nd EMSA Meeting. Proc. Symposium on Intracellular junction in the lens (1984)

Chapter: Calmodulin-mediated gating of lens gap junction channels in vesicles

Authors: Peracchia, C., and S. J. Girsch

Publisher: San Francisco Press, San Francisco, CA 1984

Cardiac Rate and Rhythm (1982)

Chapter: Gap junction structure in coupled and uncoupled conditions

Authors: Peracchia, C.

Publisher: M. Nijhoff, The Hague 1982

Membranes and Transport. A Critical Review (1982)

Chapter: Gap junction transport regulation

Authors: Peracchia, C.

Publisher: Plenum Publishing Corp., New York 1982