Andrea Sant, Ph.D.
Contact
Looking for more Information?
Visit my lab website to learn more about my research, collaborators, latest news, etc.
Andrea Sant, Ph.D.
About Me
Faculty Appointments
Professor - Department of Microbiology and Immunology, Center for Vaccine Biology and Immunology (SMD)
Credentials
Education
PhD | Washington University. Immunology. 1985
BA | SUNY College at Oswego. Chemistry and Biology. 1977
Awards
AAI Awards Committee. 2013
Section Editor. 2013
Ad Hoc reviewer. 2013
Ad Hoc reviewer. 2012
Ad Hoc reviewer. 2012
Chair. 2005 - 2007
Ad Hoc reviewer. 2003 - 2005
Elected to Faculty of 1000 in Immunology. 2002
Ad Hoc reviewer. 2001
Breast Cancer Study Section. 2000
Study Section. 1999
Ad Hoc reviewer. 1999
Breast Cancer Study Section. 1998
Study Section. 1997
Chair. 1996 - 1997
Study Section Co-Chair. 1996 - 1999
Ad Hoc reviewer. 1994 - 1996
Ad Hoc reviewer. 1994 - 1995
Zeisler Junior Faculty Scholars Award. 1989 - 1990
Research
The influenza-specific CD4 T cell repertoire in humans is established through periodic exposures to infection and vaccination that each lead to distinct signatures of CD4 T cell memory. Our data suggests that the CD4 T cell repertoire specific for influenza viruses are highly variable in abundance, specificity and functionality. It is our hypothesis that deficits in particular subsets of CD4 T cells recruited into the response are associated with less robust or effective antibody responses and diminished protection mediated by the cellular components of the adaptive immune response. Accordingly, our laboratory seeks to develop and analyze improved strategies for human vaccination and to the development of molecular strategies to both foster protective immunity in the host and to dissect both predictors and correlates of protective immunity to vaccines and virus infections.
Recently accepted papers
DiPiazza, A.T, Fan, S, Rattan, Chaves, F., Newmann, G., Kawaoka, Y. and Sant, A.J. 2019. A novel vaccine strategy to overcome poor immunogenicity of avian influenza vaccines through mobilization of memory CD4 T cells established by seasonal influenza. J. Immunol. In press
Richards, K. A, Shannon, I, Treanor, J.J. Yang, H, Nayak, J. Sant, A.J. 2019. Evidence that blunted CD4 T cell responses underlie deficient antibody responses to influenza vaccines in repeatedly vaccinated human subjects. Journal of Infectious Diseases, In press
Rattan, A. Richards, K.A., Knowlden, Z.A. and Sant, A.J. 2019. Protein vaccination directed the CD4 T cell response towards shared protective epitopes that can be recalled after influenza infection. Journal of Virology, In press
Publications
Journal Articles
Richards KA, Changrob S, Thomas PG, Wilson PC, Sant AJ
iScience.. 2024 June 2127 (6):109992. Epub 05/17/2024.
White CL, Glover MA, Gandhapudi SK, Richards KA, Sant AJ
Vaccines.. 2024 March 712 (3)Epub 03/07/2024.
Henson TR, Richards KA, Gandhapudi SK, Woodward JG, Sant AJ
Viruses.. 2023 February 1515 (2)Epub 02/15/2023.
Moritzky SA, Richards KA, Glover MA, Krammer F, Chaves FA, Topham DJ, Branche A, Nayak JL, Sant AJ
The Journal of infectious diseases.. 2023 February 1227 (3):381-390. Epub 1900 01 01.
Nelson SA, Richards KA, Glover MA, Chaves FA, Crank MC, Graham BS, Kanekiyo M, Sant AJ
NPJ vaccines.. 2022 October 267 (1):124. Epub 10/26/2022.
Sant AJ, Wilson PC
Nature immunology.. 2022 October 23 (10):1403-1404. Epub 1900 01 01.
Sant AJ, Stern LJ
Current opinion in immunology.. 2022 October 78 :102244. Epub 09/28/2022.
Richards KA, Lavery C, Keller GLJ, Miller J, Baker BM, Sant AJ
Molecular immunology.. 2022 March 143 :17-26. Epub 01/05/2022.
Rattan A, White CL, Nelson S, Eismann M, Padilla-Quirarte H, Glover MA, Dileepan T, Marathe BM, Govorkova EA, Webby RJ, Richards KA, Sant AJ
Pathogens.. 2022 February 1511 (2)Epub 02/15/2022.
Nelson SA, Dileepan T, Rasley A, Jenkins MK, Fischer NO, Sant AJ
Journal of virology.. 2021 July 2695 (16):e0084121. Epub 07/26/2021.
Richards KA, Glover M, Crawford JC, Thomas P, White C, Sant AJ
The Journal of infectious diseases.. 2021 May 20223 (9):1555-1563. Epub 1900 01 01.
Nelson SA, Sant AJ
Frontiers in immunology.. 2021 12 :808527. Epub 12/14/2021.
Richards KA, Moritzky S, Shannon I, Fitzgerald T, Yang H, Branche A, Topham DJ, Treanor JJ, Nayak J, Sant AJ
NPJ vaccines.. 2020 August 265 (1):77. Epub 08/26/2020.
Richards KA, Shannon I, Treanor JJ, Yang H, Nayak JL, Sant AJ
The Journal of infectious diseases.. 2020 June 29222 (2):273-277. Epub 1900 01 01.
Koroleva M, Batarse F, Moritzky S, Henry C, Chaves F, Wilson P, Krammer F, Richards K, Sant AJ
NPJ vaccines.. 2020 January 105 (1):3. Epub 01/10/2020.
Koroleva M, Batarse F, Moritzky S, Henry C, Chaves F, Wilson P, Krammer F, Richards K, Sant AJ
NPJ vaccines.. 2020 5 (1):3. Epub 01/10/2020.
Richards KA, Moritzky S, Shannon I, Fitzgerald T, Yang H, Branche A, Topham DJ, Treanor JJ, Nayak J, Sant AJ
NPJ vaccines.. 2020 5 :77. Epub 08/26/2020.
Knowlden ZAG, Richards KA, Moritzky SA, Sant AJ
Pathogens.. 2019 November 58 (4)Epub 11/05/2019.
Rattan A, Richards KA, Knowlden ZAG, Sant AJ
Journal of virology.. 2019 October 1593 (20)Epub 09/30/2019.
DiPiazza AT, Fan S, Rattan A, DeDiego ML, Chaves F, Neumann G, Kawaoka Y, Sant AJ
The Journal of immunology : official journal of the American Association of Immunologists.. 2019 September 15203 (6):1502-1508. Epub 08/09/2019.
Sant AJ
The Journal of infectious diseases.. 2019 April 8219 (Suppl_1):S30-S37. Epub 1900 01 01.
Varga SM, Sant AJ
Frontiers in immunology.. 2019 10 :690. Epub 04/09/2019.
Nelson SA, Sant AJ
Frontiers in immunology.. 2019 10 :932. Epub 05/07/2019.
Richards KA, Treanor JJ, Nayak JL, Sant AJ
The Journal of infectious diseases.. 2018 August 24218 (7):1169-1174. Epub 1900 01 01.
Sant AJ, Richards KA, Nayak J
Current opinion in immunology.. 2018 August 53 :13-21. Epub 04/02/2018.
DiPiazza A, Laniewski N, Rattan A, Topham DJ, Miller J, Sant AJ
Journal of virology.. 2018 July 192 (13)Epub 06/13/2018.
Sant AJ, DiPiazza AT, Nayak JL, Rattan A, Richards KA
Immunological reviews.. 2018 July 284 (1):91-105. Epub 1900 01 01.
Richards KA, DiPiazza AT, Rattan A, Knowlden ZAG, Yang H, Sant AJ
Frontiers in immunology.. 2018 9 :655. Epub 04/06/2018.
DiPiazza AT, Richards KA, Liu WC, Albrecht RA, Sant AJ
Methods in molecular biology.. 2018 1836 :513-530. Epub 1900 01 01.
DiPiazza A, Nogales A, Poulton N, Wilson PC, MartÃnez-Sobrido L, Sant AJ
Scientific reports.. 2017 September 77 (1):10857. Epub 09/07/2017.
DiPiazza A, Richards K, Poulton N, Sant AJ
Clinical and vaccine immunology : CVI.. 2017 March 24 (3)Epub 03/06/2017.
DiPiazza A, Richards K, Batarse F, Lockard L, Zeng H, GarcÃa-Sastre A, Albrecht RA, Sant AJ
Journal of virology.. 2016 September 190 (17):7991-8004. Epub 08/12/2016.
Knowlden ZA, Sant AJ
Scientific reports.. 2016 June 226 :28287. Epub 06/22/2016.
DiPiazza A, Richards KA, Knowlden ZA, Nayak JL, Sant AJ
Frontiers in immunology.. 2016 7 :10. Epub 01/25/2016.
Leddon SA, Richards KA, Treanor JJ, Sant AJ
Immunology.. 2015 September 146 (1):157-62. Epub 07/14/2015.
Richards KA, Nayak J, Chaves FA, DiPiazza A, Knowlden ZA, Alam S, Treanor JJ, Sant AJ
The Journal of infectious diseases.. 2015 July 1212 (1):86-94. Epub 12/09/2014.
Nayak JL, Richards KA, Yang H, Treanor JJ, Sant AJ
The Journal of infectious diseases.. 2015 May 1211 (9):1408-17. Epub 11/06/2014.
Alam S, Knowlden ZA, Sangster MY, Sant AJ
Journal of virology.. 2014 January 88 (1):314-24. Epub 10/23/2013.
Weilhammer DR, Blanchette CD, Fischer NO, Alam S, Loots GG, Corzett M, Thomas C, Lychak C, Dunkle AD, Ruitenberg JJ, Ghanekar SA, Sant AJ, Rasley A
Biomaterials.. 2013 December 34 (38):10305-18. Epub 09/27/2013.
Sant AJ, Chaves FA, Leddon SA, Tung J
Frontiers in immunology.. 2013 October 234 :340. Epub 10/23/2013.
Nayak JL, Alam S, Sant AJ
The Journal of immunology : official journal of the American Association of Immunologists.. 2013 August 1191 (3):1001-5. Epub 06/21/2013.
Tung J, Sant AJ
The Journal of immunology : official journal of the American Association of Immunologists.. 2013 July 15191 (2):764-72. Epub 06/14/2013.
Nayak JL, Fitzgerald TF, Richards KA, Yang H, Treanor JJ, Sant AJ
The Journal of infectious diseases.. 2013 January 15207 (2):297-305. Epub 11/12/2012.
Richards KA, Chaves FA, Alam S, Sant AJ
Vaccine.. 2012 December 1731 (1):219-25. Epub 10/22/2012.
Nayak JL, Sant AJ
Immunology.. 2012 August 136 (4):425-36. Epub 1900 01 01.
Sant AJ, McMichael A
The Journal of experimental medicine.. 2012 July 30209 (8):1391-5. Epub 1900 01 01.
Chaves FA, Lee AH, Nayak JL, Richards KA, Sant AJ
The Journal of immunology : official journal of the American Association of Immunologists.. 2012 May 1188 (9):4235-48. Epub 03/30/2012.
Engels B, Chervin AS, Sant AJ, Kranz DM, Schreiber H
Molecular therapy : the journal of the American Society of Gene Therapy.. 2012 March 20 (3):652-60. Epub 01/10/2012.
Sundararajan A, Huan L, Richards KA, Marcelin G, Alam S, Joo H, Yang H, Webby RJ, Topham DJ, Sant AJ, Sangster MY
PloS one.. 2012 7 (3):e34377. Epub 03/23/2012.
Leddon SA, Sant AJ
PloS one.. 2012 7 (10):e46952. Epub 10/15/2012.
Alam S, Sant AJ
Journal of virology.. 2011 December 85 (24):13310-21. Epub 10/05/2011.
Richards KA, Chaves FA, Sant AJ
Immunology.. 2011 June 133 (2):246-56. Epub 03/29/2011.
Nayak JL, Sant AJ
The Pediatric infectious disease journal.. 2011 March 30 (3):248-50. Epub 1900 01 01.
Richards KA, Topham D, Chaves FA, Sant AJ
The Journal of immunology : official journal of the American Association of Immunologists.. 2010 November 1185 (9):4998-5002. Epub 10/01/2010.
Leddon SA, Sant AJ
Current opinion in organ transplantation.. 2010 August 15 (4):505-11. Epub 1900 01 01.
Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB
Virology.. 2010 May 10400 (2):224-32. Epub 02/25/2010.
Nayak JL, Richards KA, Chaves FA, Sant AJ
Viral immunology.. 2010 April 23 (2):169-80. Epub 1900 01 01.
Weaver JM, Sant AJ
Immunologic research.. 2009 December 45 (2-3):123-43. Epub 02/07/2009.
Richards KA, Chaves FA, Sant AJ
Journal of virology.. 2009 July 83 (13):6566-77. Epub 04/22/2009.
Weaver JM, Chaves FA, Sant AJ
Proceedings of the National Academy of Sciences of the United States of America.. 2009 May 26106 (21):8647-52. Epub 05/07/2009.
Weaver JM, Lazarski CA, Richards KA, Chaves FA, Jenks SA, Menges PR, Sant AJ
The Journal of immunology : official journal of the American Association of Immunologists.. 2008 September 1181 (5):3039-48. Epub 1900 01 01.
Huang S, Gilfillan S, Kim S, Thompson B, Wang X, Sant AJ, Fremont DH, Lantz O, Hansen TH
The Journal of experimental medicine.. 2008 May 12205 (5):1201-11. Epub 04/28/2008.
Bandyopadhyay A, Arneson L, Beeson C, Sant AJ
Molecular immunology.. 2008 March 45 (5):1248-57. Epub 11/05/2007.
Larkin J, Rankin AL, Picca CC, Riley MP, Jenks SA, Sant AJ, Caton AJ
The Journal of immunology : official journal of the American Association of Immunologists.. 2008 February 15180 (4):2149-57. Epub 1900 01 01.
Menges PR, Jenks SA, Bikoff EK, Friedmann DR, Knowlden ZA, Sant AJ
The Journal of immunology : official journal of the American Association of Immunologists.. 2008 February 1180 (3):1619-33. Epub 1900 01 01.
Gardiner A, Richards KA, Sant AJ, Arneson LS
International immunology.. 2007 September 19 (9):1103-13. Epub 1900 01 01.
Richards KA, Chaves FA, Krafcik FR, Topham DJ, Lazarski CA, Sant AJ
Journal of virology.. 2007 July 81 (14):7608-19. Epub 05/16/2007.
Sant AJ, Chaves FA, Krafcik FR, Lazarski CA, Menges P, Richards K, Weaver JM
Expert review of vaccines.. 2007 June 6 (3):357-68. Epub 1900 01 01.
Chaves FA, Sant AJ
Current protocols in immunology / edited by John E. Coligan ... [et
Chaves FA, Richards KA, Torelli A, Wedekind J, Sant AJ
Biochemistry.. 2006 May 2345 (20):6426-33. Epub 1900 01 01.
Lazarski CA, Chaves FA, Sant AJ
The Journal of experimental medicine.. 2006 May 15203 (5):1319-28. Epub 05/08/2006.
Sant AJ, Chaves FA, Jenks SA, Richards KA, Menges P, Weaver JM, Lazarski CA
Immunological reviews.. 2005 October 207 :261-78. Epub 1900 01 01.
McFarland BJ, Katz JF, Sant AJ, Beeson C
Journal of molecular biology.. 2005 July 1350 (1):170-83. Epub 1900 01 01.
Lazarski CA, Chaves FA, Jenks SA, Wu S, Richards KA, Weaver JM, Sant AJ
Immunity.. 2005 July 23 (1):29-40. Epub 1900 01 01.
Chaves FA, Hou P, Wu S, Sant AJ
Journal of immunological methods.. 2005 May 300 (1-2):74-92. Epub 1900 01 01.
Arneson LS, Katz JF, Liu M, Sant AJ
The Journal of immunology : official journal of the American Association of Immunologists.. 2001 December 15167 (12):6939-46. Epub 1900 01 01.
McFarland BJ, Katz JF, Beeson C, Sant AJ
Proceedings of the National Academy of Sciences of the United States of America.. 2001 July 3198 (16):9231-6. Epub 07/24/2001.
Nanda NK, Sant AJ
The Journal of experimental medicine.. 2000 September 18192 (6):781-8. Epub 1900 01 01.
Arneson LS, Peterson M, Sant AJ
The Journal of immunology : official journal of the American Association of Immunologists.. 2000 August 15165 (4):2059-67. Epub 1900 01 01.
McFarland BJ, Sant AJ, Lybrand TP, Beeson C
Biochemistry.. 1999 December 1438 (50):16663-70. Epub 1900 01 01.
Sant AJ, Beeson C, McFarland B, Cao J, Ceman S, Bryant PW, Wu S
Immunological reviews.. 1999 December 172 :239-53. Epub 1900 01 01.
McFarland BJ, Beeson C, Sant AJ
The Journal of immunology : official journal of the American Association of Immunologists.. 1999 October 1163 (7):3567-71. Epub 1900 01 01.
Bryant PW, Roos P, Ploegh HL, Sant AJ
European journal of immunology.. 1999 September 29 (9):2729-39. Epub 1900 01 01.
Siemasko K, Eisfelder BJ, Stebbins C, Kabak S, Sant AJ, Song W, Clark MR
The Journal of immunology : official journal of the American Association of Immunologists.. 1999 June 1162 (11):6518-25. Epub 1900 01 01.
McFarland, B. J.; Sant, A. J.; Beeson, C.;.
1999; 121: 11225-11226.
Ceman S, Wu S, Jardetzky TS, Sant AJ
The Journal of experimental medicine.. 1998 December 7188 (11):2139-49. Epub 1900 01 01.
Peterson M, Sant AJ
The Journal of immunology : official journal of the American Association of Immunologists.. 1998 September 15161 (6):2961-7. Epub 1900 01 01.
Tan LJ, Ceman S, Chervonsky A, Rodriguez-Paris J, Steck TL, Sant AJ
European journal of immunology.. 1997 June 27 (6):1479-88. Epub 1900 01 01.
Stebbins CC, Peterson ME, Suh WM, Sant AJ
The Journal of immunology : official journal of the American Association of Immunologists.. 1996 December 1157 (11):4892-8. Epub 1900 01 01.
Katz JF, Stebbins C, Appella E, Sant AJ
The Journal of experimental medicine.. 1996 November 1184 (5):1747-53. Epub 1900 01 01.
Ceman S, Sant AJ
Seminars in immunology.. 1995 December 7 (6):373-87. Epub 1900 01 01.
Zuckerman LA, Sant AJ, Miller J
The Journal of immunology : official journal of the American Association of Immunologists.. 1995 May 1154 (9):4503-12. Epub 1900 01 01.
Chervonsky A, Sant AJ
European journal of immunology.. 1995 April 25 (4):911-8. Epub 1900 01 01.
Stebbins CC, Loss GE, Elias CG, Chervonsky A, Sant AJ
The Journal of experimental medicine.. 1995 January 1181 (1):223-34. Epub 1900 01 01.
Chervonsky AV, Gordon L, Sant AJ
International immunology.. 1994 July 6 (7):973-82. Epub 1900 01 01.
Katz JF, Sant AJ
The Journal of immunology : official journal of the American Association of Immunologists.. 1994 February 15152 (4):1629-40. Epub 1900 01 01.
Sant AJ, Miller J
Current opinion in immunology.. 1994 February 6 (1):57-63. Epub 1900 01 01.
Sant AJ
Immunologic research.. 1994 13 (4):253-67. Epub 1900 01 01.
Loss GE, Elias CG, Fields PE, Ribaudo RK, McKisic M, Sant AJ
The Journal of experimental medicine.. 1993 July 1178 (1):73-85. Epub 1900 01 01.
Sant AJ
The Journal of immunology : official journal of the American Association of Immunologists.. 1993 June 15150 (12):5299-310. Epub 1900 01 01.
Loss GE, Sant AJ
The Journal of immunology : official journal of the American Association of Immunologists.. 1993 April 15150 (8 Pt 1):3187-97. Epub 1900 01 01.
McKisic MD, Sant AJ, Fitch FW
The Journal of immunology : official journal of the American Association of Immunologists.. 1991 November 1147 (9):2868-74. Epub 1900 01 01.
Sant AJ, Hendrix LR, Coligan JE, Maloy WL, Germain RN
The Journal of experimental medicine.. 1991 October 1174 (4):799-808. Epub 1900 01 01.
Lechler RI, Sant AJ, Braunstein NS, Sekaly R, Long E, Germain RN
The Journal of immunology : official journal of the American Association of Immunologists.. 1990 January 1144 (1):329-33. Epub 1900 01 01.
Sant AJ, Germain RN
Cell.. 1989 June 257 (5):797-805. Epub 1900 01 01.
Sant AJ, Zacheis M, Rumbarger T, Giacoletto KS, Schwartz BD
The Journal of immunology : official journal of the American Association of Immunologists.. 1988 January 1140 (1):155-60. Epub 1900 01 01.
Germain RN, Sant AJ, Braunstein NS, Ronchese F
Princess Takamatsu symposia. 1988 19 :179-91. Epub 1900 01 01.
Sant AJ, Braunstein NS, Germain RN
Proceedings of the National Academy of Sciences of the United States of America.. 1987 November 84 (22):8065-9. Epub 1900 01 01.
Giacoletto KS, Sant AJ, Bono C, Gorka J, O'Sullivan DM, Quaranta V, Schwartz BD
The Journal of experimental medicine.. 1986 November 1164 (5):1422-39. Epub 1900 01 01.
Sant AJ, Cullen SE, Giacoletto KS, Schwartz BD
The Journal of experimental medicine.. 1985 December 1162 (6):1916-34. Epub 1900 01 01.
Sant AJ, Cullen SE, Schwartz BD
The Journal of immunology : official journal of the American Association of Immunologists.. 1985 July 135 (1):416-22. Epub 1900 01 01.
Sant AJ, Schwartz BD, Cullen SE
The Journal of immunology : official journal of the American Association of Immunologists.. 1985 July 135 (1):408-15. Epub 1900 01 01.
Sant AJ, Cullen SE, Schwartz BD
Proceedings of the National Academy of Sciences of the United States of America.. 1984 March 81 (5):1534-8. Epub 1900 01 01.
Sant AJ, Schwartz BD, Cullen SE
The Journal of experimental medicine.. 1983 December 1158 (6):1979-92. Epub 1900 01 01.
Books
Immunodominance: The Choice of the Immune System (2006)
Chapter: The Mechanics of Class II Processing: Establishment of a Class II Hierarchy
Authors: Drake J; Sant AJ
Publisher: Wiley-VCH 2006
Antigen Processing and Presentation (1994)
Chapter: Intracellular events regulating MHC Class II restricted antigen presentation
Authors: Sant, AJ, Chervonsky, A, Dykhuizen, M, Katz, JF, Loss, GE, Stebbins, C, and LJ Tan
Publisher: Academic Press 1994
Antigen Presenting Cells: Diversity, Differentiation and Regulation (1988)
Chapter: DNA-mediated gene transfer as a tool for analyzing la structure-function relationships and antigen presentation
Authors: Braunstein, NS, Ronchese, F, Sant, AJ, Schwartz, RH, Lechler, RI, and Germain, RN
Publisher: Alan R. Liss, Inc. 1988
Processing and Presentation of Antigens (1988)
Chapter: la structure and immune recognition
Authors: Germain, RN, Braunstein, NS, Lechler, RI, Miller, J, Ronchese, F, and Sant, AJ
Publisher: Academic Press NY 1988