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Center for Community Health & Prevention

Surveillance & Prevention

URMC / Center for Community Health & Prevention / Surveillance & Prevention / Emerging Infections Program / HPV Vaccine Impact
 

Human Papillomavirus Vaccine Impact Monitoring Project

Purpose

The Human Papillomavirus (HPV) Vaccine Impact Project (HPV-IMPACT), part of the Centers for Disease Control and Prevention Emerging Infections Program (EIP) is an ongoing that monitors the impact of HPV vaccine on HPV types associated with cervical cancer and cervical cancer precursors. HPV-IMPACT determines rates of high-grade cervical lesions in women in the United States. 

Goals and Objectives

  • HPV VirusDescribe the incidence of HPV-associated high-grade cervical lesions and cervical cancer over time.
  • Obtain diagnostic biopsy specimens on all reported cases of high-grade cervical lesions in females 18 to 39 years of age in Monroe County.
  • Obtain additional detailed information on all reported cases of high-grade cervical lesions in females 18 to 39 years of age in Monroe County, including HPV vaccination history, complete demographic information and relevant medical history.
  • Describe cervical cancer screening utilization among females 18 to 39 years to monitor trends over time using methodology other than self-report.

Activities

The pathology laboratories in our catchment area continue to identify all cases of high-grade cervical lesions and cervical cancer in women 18 years of age and older. Lists are generated at each lab every month, using anatomic site language to capture all possible cases. Using a combination of administrative data and medical records, complete case information is collected. This includes: patient demographics, health insurance information, ordering provider and submitting pathologist contact information, cervical pathology information related to the current diagnosis, and detailed information relevant to women aged 18 to 39 years as outlined above.

Women aged 18 to 39 have a cervical pathology specimen selected for highest grade associated with that infection by the designated lab pathologist, retrieved, prepared and submitted to the CDC for histopathologic review and HPV typing.

Publications

  • Russ S., Kurtz R., Bennett N.M., Felson C., Bostick E. , Gynecologic Oncology Reports, Volume 55, 2024, 101480, ISSN 2352-5789, https://doi.org/10.1016/j.gore.2024.101480.

  • Rosenblum HG, Gargano JW, Cleveland AA, Dahl RM, Park IU, Whitney E, Castilho JL, Sackey E, Niccolai LM, Brackney M, Debess E, Ehlers S, Bennett NM, Kurtz R, Unger ER, Markowitz LE. J Womens Health (Larchmt). 2024 Apr 12. doi: 10.1089/jwh.2023.0462. Epub ahead of print. PMID: 38608239.

  • Gargano JW, McClung N, Lewis RM, Park IU, Whitney E, Castilho JL, Pemmaraju M, Niccolai LM, Brackney M, Debess E, Ehlers S, Bennett NM, Scahill M, Cleveland AA, Querec TD, Unger ER, Markowitz LE; Int J Cancer. 2022 Jul 29. doi: 10.1002/ijc.34231. Epub ahead of print. PMID: 35904861.
  • Cleveland AA, Gargano JW, Griffin MR, Park IU, Niccolai LM, Bennett NM, Pemmaraju M, Fink D, Brackney M, Scahill M, Ehlers SJ, Unger ER, Markowitz LE; HPV-IMPACT Working Group. J Low Genit Tract Dis. 2021 Jul 1;25(3):192-198. doi: 10.1097/LGT.0000000000000606. PMID: 33797511.
  • Johnson Jones ML, Gargano JW, Powell M, Bennett NM, et al. Am J Epidemiol. 2020; 189(4):265-276. doi:10.1093/aje/kwz253 
  • McClung NM, Gargano JW, Park IU, Whitney E, Abdullah N, Ehlers S, Bennett NM, Scahill M, Niccolai LM, Brackney M, Griffin MR, Pemmaraju M, Querec TD, Cleveland AA, Unger ER, Markowitz LE; HPV-IMPACT Working Group.  MMWR Morb Mortal Wkly Rep. 2019 April; 68(15):337-343. doi: 10.15585/mmwr.mm6815a1.
  • Cleveland AA, Gargano JW, Park IU, Griffin MR, Niccolai MP, Bennett NM, Saadeh K, Manideepthi P, Higgins K, Ehlers S, Scahill M, Johnson Jones ML, Querec T, Markowitz LE, Unger ER; for the HPV-IMPACT Working Group. International Journal of Cancer, April 2019, doi: 10.1002/ijc.32340. [Epub ahead of print]
  • McClung NM, Gargano JW, Bennett NM, Niccolai LM, Abdullah N, Griffin MR, Park IU, Cleveland AA, Querec TD, Unger ER and Markowitz LE; for the HPV-IMPACT Working Group. . Cancer Epidemiol Biomarkers Prev., Feb 2019. doi: 10.1158/1055-9965. EPI-18-0885. (Epub ahead of print)
  • Bennett NM; . JAMA, Jan. 2019. doi:10.1001/jama.2018.20792. 
  • Gargano JW, Park IU, Griffin MR, Niccolai LM, Powell M, Bennett NM, Johnson Jones ML, Whitney E, Pemmaraju M, Brackney M, Abdullah N, Scahill M, Dahl RM, Cleveland AA, Unger ER, Markowitz LE; HPV-IMPACT Working Group.  Clin Infect Dis. 2018 Aug 23. doi: 10.1093/cid/ciy707.
  • Hariri S, Unger ER, Powell SE, Bauer HM, Bennett NM, Bloch KC, Niccolai LM, Schafer S, Markowitz LE; HPV-IMPACT Working Group. Cancer Causes and Control 2012: Feb 23(2):281-288.