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Center for Community Health & Prevention

Surveillance & Prevention

URMC / Center for Community Health & Prevention / Surveillance & Prevention / Emerging Infections Program / MuGSI
 

Multi-Site Gram-negative Surveillance Initiative (MUGSI)

Purpose

MUGSIGram-negative bacilli commonly cause infections in both health care and community settings. Emergence of resistance of these organisms to several antibiotics, such as carbapenems, makes treatment of these organisms more challenging. Examples of gram-negative bacilli include E. coli and K. pneumoniae. To monitor trends in the incidence of carbapenem resistant Enterobacteriaceae (“CRE”) and Extended-Spectrum β-Lactamases (ESBLs) Enterobacteriaceae, we conduct population-based surveillance among residents of Monroe County, NY, as part of the Centers for Disease Control and Prevention (CDC) Emerging Infections Program . 

Goals and Objectives

  • Determine the extent of CRE, carbapenem-resistant Acinetobacter and ESBLs disease in Monroe County
  • Identify people most at risk for illness from these organisms
  • Measure trends of disease over time
  • Describe the epidemiology of bloodstream and urinary tract infections caused by E.coli to identify priority areas for future surveillance, public health interventions and vaccine development

Activities

Working with laboratories in Monroe County, the surveillance team identifies carbapenem resistant organisms, as well as those resistant to third generation cephalosporins. Demographic data and potential risk factors for infection and prior exposure to health care are collected. Selected isolates are sent to the CDC for further study.

Our Newsletter

Extended-Spectrum Beta-Lactamase Enterobacterales Surveillance, Monroe County, NY, 2020-2022

Publications 

  • Grome HN; Grass JE; Duffy N; Bulens SN; Ansari U; Campbell D; Lutgring JD; Gargis AS; Masters T; Kent AG; McKay SL; Smith G; Wilson LE; Vaeth E; Evenson B; Dumyati G; Tsay R; Phipps E; Flores K; Wilson CD; Czaja CA; Johnston H; Janelle SJ; Lynfield R; O'Malley S; Vagnone PS; Maloney M; Nadle J; Guh AY  Emerging infectious diseases.. 2024; 30(6):1104-1114.
  • Bulens, SN., Campbell, D., McKay, SL., Vlachos, N., Burgin, A., Burroughs, M. Padila, J., Grass, JE.,  Jacob, JT., Smith, G., Muleta, DB., Maloney, M., Macierowski, B., Wilson, LE., Vaeth, E., Lynfield, R., O’Malley, S., Snippes Vagnone, PM., Dale, J., Janelle, SJ., Czaja, CA., Johnson, H., Phipps, EC., Flores, KG., Dumyati, G., Tsay, R., et al., , American Journal of Infection Control, 2024,,ISSN 0196-6553, https://doi.org/10.1016/j.ajic.2024.04.184.
  • Duffy, N., Li, R., Czaja, CA, Johnston, H., Janelle, SJ, Jacob JT, Smith G., Wilson LE, Vaeth E., Lynfield R., O’Malley S., Vagnone, PS, Dumyati G., Tsay R., Bulens SN, Grass JE, Pierce R., Cassidy, PM, Hertzel H., Wilson C., Muleta D., Taylor J., Guh AY, , Open Forum Infectious Diseases, 2023;, ofad609, https://doi.org/10.1093/ofid/ofad609
  • Bulens, S., Reses, H., Uzma, A.,,Grass, J., Carmon, C., Albrecht, V., Dumyati, G.,Tsay, R., et al.(2022),, American Journal of Infection Control, ISSN 0196-6553, https://doi.org/10.1016/j.ajic.2022.04.003
  • Duffy, N., Karlsson, M., Reses, H., Campbell, D., Daniels, J., Stanton, R., Tsay, R., Dumyati, G., et al. (2022).  Infection Control & Hospital Epidemiology, 1-9. doi:10.1017/ice.2021.496
  • Wozniak JE; Band VI; Conley A; Rishishwar L; Burd EM; Satola SW; Hardy D; Tsay R; Farley MM; Jacob JT; Dumyati G; Jordan IK; Weiss DS.  Antimicrob agents and chemother. 2019;Epub 2019 Feb 25. doi: 10.1128/AAC.00107-19.
  • Bulens SN, Yi SH, Walters MS, Jacob JT, Bower C, Reno J, Wilson L, Vaeth E, Bamberg W, Janelle SJ, Lynfield R, Vagnone PS, Shaw K, Kainer M, Muleta D, Mounsey J, Dumyati G, Concannon C, Beldavs Z, Cassidy PM, Phipps EC, Kenslow N, Hancock EB, Kallen AJ. . Emerging Infectious Diseases. 2018 Apr;24(4):727-34. doi: 10.3201/eid2404.171461.
  • Guh, A: Bulens., SN; Mu, Y; Jacob, JT; Reno, J; Scott, J; Wilson, LE, Sc,M; Vaeth, E; Lynfield, R; Shaw, KM; Snippes, PM; Vagnone, MT(ASCP); Bamberg, WM; Janelle, SJ; Dumyati, G; Concannon, C; Beldavs, Z; Cunningham, M; Cassidy, M; Phipps, EC; Kenslow, N; Travis, T; Lonsway, D; Rasheed, JK; Limbago, BM; Kallen, AJ. Epidemiology of Carbapenem-Resistant Enterobacteriaceae in 7 US Communities, 2012-2013. Journal of the American Medical Association. 5 October 2015.